Planta Med 2006; 72(1): 75-78
DOI: 10.1055/s-2005-873178
Letter
© Georg Thieme Verlag KG Stuttgart · New York

New Cytotoxic 6-Oxygenated 8,9-Dihydrofurocoumarins, Hedyotiscone A - C, from Hedyotis biflora

Yung-Husan Chen1 , Fang-Rong Chang1 , Chin-Chung Wu1 , Ming-Hon Yen1 , Chih-Chuang Liaw1 , Hui-Chi Huang1 , Yao-Haur Kuo2 , Yang-Chang Wu1
  • 1Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
  • 2National Research Institute of Chinese Medicine, Taipei, Taiwan, R.O.C.
Further Information

Publication History

Received: March 15, 2005

Accepted: June 20, 2005

Publication Date:
10 November 2005 (online)

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Abstract

Using the bioactivity-guided fractionation method, three new 6-oxygenated 8,9-dihydrofurocoumarin-type compounds, hedyotiscones A (1), B (2), and C (3) were isolated from the methanol extract of Hedyotis biflora together with seven known compounds. The structures of all isolated compounds were determined on the basis of mass and spectroscopic evidence. Compounds 1 - 3, oleanolic acid, and 6′-(β-sitosteryl-3-O-β-D-glucopyranosidyl) pentadecanoate showed marginal cytotoxicity against Hep G2 cells (human liver cancer cells) with IC50 values of 14.4, 17.4, 4.9, 8.0, and 9.2 μg/mL, respectively. Ursolic acid showed significant cytotoxicity against MDA-MB-231 cells (human breast carcinoma cells) with an IC50 value of 1.49 μg/mL.

References

Prof. Dr. Yang-Chang Wu

Graduate Institute of Natural Products

Kaohsiung Medical University

100 Shih-Chuan, 1st Road

San Ming District

Kaohsiung 807

Taiwan

Republic of China

Phone: +886-7-3121101 ext. 2197

Fax: +886-7-3114773

Email: yachwu@kmu.edu.tw