Planta Med 2005; 71(12): 1128-1133
DOI: 10.1055/s-2005-873169
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Evaluation of Antiviral Activity of Compounds Isolated from Ranunculus sieboldii and Ranunculus sceleratus

Haibo Li1 , ChangXin Zhou1 , Yunxue Pan1 , Xiaozhong Gao1 , Xiumei Wu2 , Hua Bai2 , Linfu Zhou3 , Zhi Chen3 , Shuili Zhang1 , Shuyun Shi1 , Jiali Luo2 , Juanhua Xu1 , Liurong Chen1 , Xiaoxiang Zheng4 , Yu Zhao1
  • 1Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China
  • 2Zhejiang Hisun Naturelite Pharmaceutical R&D Co., Ltd., Hangzhou, P. R. China
  • 3Institute of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, P. R. China
  • 4Department of Biomedical Engineering, College of Biomedical Engineering and Instrument Sciences, Zhejiang University, Hangzhou, P. R. China
Further Information

Publication History

Received: November 25, 2004

Accepted: July 13, 2005

Publication Date:
10 November 2005 (online)

Abstract

Nineteen compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus were tested for inhibitory effects on hepatitis B virus (HBV) and Herpes simplex virus type-1 (HSV-1). The results showed that apigenin 4′-O-α-rhamnopyranoside (1), apigenin 7-O-β-glucopyranosyl-4′-O-α-rhamnopyranoside (4), tricin 7-O-β-glucopyranoside (5), tricin (12), and isoscopoletin (18) possessed inhibitory activity against HBV replication. Protocatechuyl aldehyde (19) exhibited an inhibiting activity on HSV-1 replication. It is therefore suggested that further investigations on these bioactive compounds might be needed to discover and develop new antiviral agents.

References

Prof. Dr. Yu Zhao

Department of Traditional Chinese Medicine and Natural Drug Research

College of Pharmaceutical Sciences

Zhejiang University

Hangzhou 310031

People’s Republic of China

Fax: +86-571-8527-0026

Email: dryuzhao@zju.edu.cn