Planta Med 2005; 71(12): 1165-1167
DOI: 10.1055/s-2005-873163
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Flavonoids and New Chromenes from Ficus formosana f. formosana

Ya-Wen Sheu1 , Lien-Chai Chiang2 , Ih-Sheng Chen1 , Yu-Chang Chen1 , Ian-Lih Tsai1
  • 1Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
  • 2Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
Further Information

Publication History

Received: February 5, 2005

Accepted: June 1, 2005

Publication Date:
10 November 2005 (online)


Two new chromenes, ficuformodiol A (1) and ficuformodiol B (2), and nine known compounds including one chromene, spatheliachromen (3), six flavonoids, obovatin (4), carpachromene (5), apigenin (6), norartocarpetin (7), steppogenin (8), 6-prenylpinocembrin (9), one benzopyran, chromenylacrylic acid (10), and one isocoumarin, (R)-(-)-mellein (11), were obtained from the cytotoxic chloroform-soluble fraction of the stems of Ficus formosana f. formosana (Moraceae). Their structures were determined by means of spectroscopic analyses. Compounds 5, 6 and 7 exhibited significant cytotoxicity against HepG2, PLC/PRF/5 and Raji cancer cell lines in vitro.


Prof. Dr. Ian-Lih Tsai

Graduate Institute of Natural Products

College of Pharmacy

Kaohsiung Medical University

807 Kaohsiung


Republic of China

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