Planta Med 2005; 71(12): 1170-1172
DOI: 10.1055/s-2005-873146
© Georg Thieme Verlag KG Stuttgart · New York

Lipolytic Activity of Cirsimarin Extracted from Microtea debilis

Catherine Girotti1 , Morgane Ginet1 , Frédérique C. Demarne1 , Michel Lagarde2 , Alain Géloën2
  • 1Gattefossé S.A., Saint-Priest cedex, France
  • 2UMR 585 INSERM, INSA de Lyon, IMBL, Villeurbanne cedex, France
Further Information

Publication History

Received: October 19, 2004

Accepted: July 18, 2005

Publication Date:
20 October 2005 (online)


This study explores the ability of cirsimarin, a plant flavonoid, to trigger lipid mobilization. Cirsimarin was extracted from Microtea debilis Swartz (Phytolaccaceae) and purified by preparative HPLC. Its lipolytic activity was assessed on isolated adipocytes from rats and compared to that of caffeine, a well known lipolytic agent. The results show an EC50 = 0.025 ± 0.01 mM for cirsimarin (n = 4) and of 0.49 ± 0.08 mM for caffeine (n = 4). Furthermore, we show that cirsimarin inhibits phosphodiesterase, the enzyme that modulates cyclic nucleotide signalling. In conclusion, our results demonstrate that cirsimarin exerts strong lipolytic properties being 20 times more potent than caffeine to stimulate lipolysis, at least in part through cyclic nucleotide preservation.


Alain Géloën


INSA de Lyon


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