Planta Med 2005; 71(12): 1176-1178
DOI: 10.1055/s-2005-873139
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Activity of Some Natural and Synthetic Sesquiterpene Lactones

Maurizio Bruno1 , Sergio Rosselli1 , Antonella Maggio1 , Rosa Angela Raccuglia1 , Kenneth F. Bastow2 , Chin-Chung Wu2 , Kuo-Hsiung Lee2
  • 1Dipartimento di Chimica Organica, Università di Palermo, Palermo, Italy
  • 2Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Further Information

Publication History

Received: April 13, 2005

Accepted: May 27, 2005

Publication Date:
10 November 2005 (online)

Abstract

Several natural and synthetic sesquiterpene lactones with different skeletons were tested and found to be active against nine cancer cell lines. Elemane (4), heliangolane (5) and their hydroxy analogues 9 and 10, all containing an α,β-unsaturated aldehyde substituent, were the most potent compounds.

References

Prof. Maurizio Bruno

Dipartimento di Chimica Organica ”E. Paternò”

Università di Palermo

Viale delle Scienze

Parco d’Orleans II

90128 Palermo

Italy

Phone: +39-(0)91-596-905

Fax: +39-(0)91-596-825

Email: bruno@dicpm.unipa.it