Locally Applied Mononuclear Bone Marrow Cells Restore Angiogenesis and Promote Wound Healing in a Type 2 Diabetic Patient

Abstract

We treated a patient with type 2 diabetes suffering from chronic venous and neuro-ischemic wounds not healing under standard care with local application of autologous bone marrow cells (mBMC) isolated from bone marrow aspirate. This procedure led to a reduction of wound size, a markedly increased vascularization and infiltration of mononuclear cells, 7 days after treatment, without any signs of a systemic reaction to treatment. Locally applied mBMC could, therefore, provide a treatment option in end stage diabetic wound healing disorders.

Key words

Wound healing - type 2 diabetes - bone marrow cells

References

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