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Exp Clin Endocrinol Diabetes 2005; 113(10): 593-597
DOI: 10.1055/s-2005-872840
Article

J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The Trp64Arg β3-Adrenergic Receptor Amino-Acid Variant is not Associated with Overweight and Type 2 Diabetes Mellitus in Polish Population

J. Kasznicki1 , J. Blasiak2 , I. Majsterek2 , K. Przybyłowska2 , J. Drzewoski1
  • 1Department of Clinical Pharmacology, Medical University of Lodz, Lodz, Poland
  • 2Department of Molecular Genetics, University of Lodz, Lodz, Poland
Further Information

Publication History

Received: November 19, 2004 First decision: January 5, 2005

Accepted: August 22, 2005

Publication Date:
30 November 2005 (online)

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Abstract

The Trp64Arg amino-acid variant of the β3 adrenoreceptor gene may be associated with a genetic predisposition to human obesity and related disorders, including type 2 diabetes mellitus. This relationship has been reported in various ethnic groups, however it was not extensively studied in Polish population. Therefore, the aim of the study was to investigate the association of Trp64Arg polymorphism of the β3 adrenergic receptor gene with overweight and type 2 diabetes mellitus in polish subjects. The Trp64Arg polymorphism was determined by PCR-based MspI restriction fragment length polymorphism (PCR-RFLP). The study population consisted of 358 subjects, among whom 200 were diagnosed as overweight (BMI > 27 kg/m2). Among overweight subjects 111 presented with type 2 diabetes mellitus and 89 with normal glucose metabolism. All study participants were unrelated Caucasians and inhabited the city of Lodz, Poland. The frequency of the Arg allele did not differ significantly between overweight and normal weight patients (13 % vs. 11 %, OR 1.17, CI 0.74 - 1.85). The same applied to overweight diabetic patients vs. overweight patients without diabetes mellitus (13 % vs. 13 %, OR 0.97, CI 0.54 - 1.76). The obtained results suggest no association between Trp64Arg polymorphism of the β3-AR gene and the incidence of overweight and type 2 diabetes mellitus in Polish population.

Key words

β3-adrenergic receptor - genetic polymorphism - overweight - type 2 diabetes mellitus

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MD, PhD Jacek Kasznicki

Department of Clinical Pharmacology
Medical University of Lodz

Lodz

Poland

Email: jkasznicki@up.pl

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