Synlett 2005(14): 2171-2174  
DOI: 10.1055/s-2005-872250
LETTER
© Georg Thieme Verlag Stuttgart · New York

New Efficient Preparation of Functionalized Arylzinc or Thienylzinc ­Compounds from Aryl or Thienyl Chlorides Using Cobalt Catalysis

Corinne Gosmini*, Muriel Amatore, Stéphanie Claudel, Jacques Périchon
Laboratoire d’Electrochimie, Catalyse et Synthèse Organique, UMR 7582, Université Paris 12-CNRS, 2 Rue Henri Dunant, 94320 Thiais, France
Fax: +(33)149781148; e-Mail: gosmini@glvt-cnrs.fr;
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Publikationsverlauf

Received 21 June 2005
Publikationsdatum:
03. August 2005 (online)

Abstract

A new chemical method is described for the preparation of aryl or thienyl zinc intermediates from their corresponding aromatic or thienyl chlorides in a mixture of acetonitrile-pyridine, using cobalt catalysis. This procedure allows for the synthesis of a variety of functionalized arylzinc species from reactive arylchlorides or chlorothiophenes in good to excellent yields. Some of these arylzinc compounds have been coupled with aromatic bromides using palladium catalysis.