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Synlett 2005(14): 2171-2174
DOI: 10.1055/s-2005-872250
DOI: 10.1055/s-2005-872250
LETTER
© Georg Thieme Verlag Stuttgart · New York
New Efficient Preparation of Functionalized Arylzinc or Thienylzinc Compounds from Aryl or Thienyl Chlorides Using Cobalt Catalysis
Weitere Informationen
Received
21 June 2005
Publikationsdatum:
03. August 2005 (online)
Publikationsverlauf
Publikationsdatum:
03. August 2005 (online)
Abstract
A new chemical method is described for the preparation of aryl or thienyl zinc intermediates from their corresponding aromatic or thienyl chlorides in a mixture of acetonitrile-pyridine, using cobalt catalysis. This procedure allows for the synthesis of a variety of functionalized arylzinc species from reactive arylchlorides or chlorothiophenes in good to excellent yields. Some of these arylzinc compounds have been coupled with aromatic bromides using palladium catalysis.
Key words
cobalt halide - catalysis - zinc - thiophenes - aromatic chlorides
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