Planta Med 2005; 71(7): 640-645
DOI: 10.1055/s-2005-871270
Original Paper
Biochemistry and Molecular Biology
© Georg Thieme Verlag KG Stuttgart · New York

Effects of Evodia rutaecarpa and Rutaecarpine on the Pharmacokinetics of Caffeine in Rats

Tung-Hu Tsai1 , 2 , Chun-Hao Chang3 , Lie-Chwen Lin1
  • 1National Research Institute of Chinese Medicine, Taipei, Taiwan
  • 2Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan
  • 3Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan
Further Information

Publication History

Received: September 16, 2004

Accepted: February 14, 2005

Publication Date:
18 July 2005 (online)


To assess possible herb-drug interactions, rutaecarpine (an herbal ingredient of Evodia rutaecarpa; 25 mg/kg/day, p. o.), the ethanol extract of Evodia rutaecarpa (1 g/kg/day, p. o.), and an herbal preparation of Evodia rutaecarpa (Wu-Chu-Yu-Tang; 1 g/kg/day) were individually pretreated daily for three consecutive days in rats and on the fourth day caffeine was administered (2 mg/kg, i. v.). Caffeine concentrations in blood, brain and bile were concurrently measured by microdialysis coupled to a liquid chromatographic system. Pharmacokinetic data were calculated by a non-compartmental model. The results indicate that the caffeine crosses the blood-brain barrier and goes through hepatobiliary excretion. The caffeine level was significantly decreased by the pretreatment of rutaecarpine, the extract of Evodia rutaecarpa and herbal preparation Wu-Chu-Yu-Tang. This finding should be very important whenever herb-drug interactions would be possible for a herbal remedy.


Prof. Tung-Hu Tsai, Ph. D.

National Research Institute of Chinese Medicine

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