Horm Metab Res 2005; 37(11): 711-715
DOI: 10.1055/s-2005-870588
Original Clinical
© Georg Thieme Verlag KG Stuttgart · New York

Prolonged Effect of Stress (Water and Food Deprivation) at Weaning or in Adult Age on the Triiodothyronine and Histamine Content of Immune Cells

G.  Csaba1 , P.  Kovács1 , L.  Tóthfalusi2 , É.  Pállinger3
  • 1Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary
  • 2Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
  • 3Molecular Immunological Research Group, Hungarian Academy of Sciences, Budapest, Hungary
Further Information

Publication History

Received 22 November 2004

Accepted after revision 26 April 2005

Publication Date:
25 November 2005 (online)


We used two days of total water and food deprivation as stress for female rats at weaning (three weeks old) and at adult age (two and a half months old). Triiodothyronine (T3) and histamine content of immune cells (lymphocytes, mast cells and monocyte-macrophage-granulocyte group in peritoneal fluid; lymphocytes, granulocytes and monocytes in blood; and lymphocytes in thymus) were studied three weeks after stress application using specific antibodies for flow cytometry and confocal microscopy. The stress at weaning increased T3 content of thymus lymphocytes. In case of adult T3, there was a cell type independent significant effect of stress, decreasing values in peritoneal fluid and slightly increasing effect in the blood. Histamine content of granulocytes was also significantly elevated. The experiments demonstrate that not only fetal or neonatal stress has long-lasting consequences, but also stress events in later periods of life in cells (organs) that are continuously differentiating. We will go on to discuss the importance of T3 and histamine in connection with stress and immunity.


György Csaba, M. D., Ph. D., D. Sc.

Department of Genetics, Cell and Immunobiology · Semmelweis University

POB 370 · 1445 Budapest · Hungary

Phone: +36 (1) 210 29 50 ·

Fax: +36 (1) 303 69 68

Email: csagyor@dgci.sote.hu