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Horm Metab Res 2005; 37(11): 711-715
DOI: 10.1055/s-2005-870588
Original Clinical
© Georg Thieme Verlag KG Stuttgart · New York

Prolonged Effect of Stress (Water and Food Deprivation) at Weaning or in Adult Age on the Triiodothyronine and Histamine Content of Immune Cells

G.  Csaba1 , P.  Kovács1 , L.  Tóthfalusi2 , É.  Pállinger3
  • 1Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary
  • 2Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
  • 3Molecular Immunological Research Group, Hungarian Academy of Sciences, Budapest, Hungary
Further Information

Publication History

Received 22 November 2004

Accepted after revision 26 April 2005

Publication Date:
25 November 2005 (online)

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Abstract

We used two days of total water and food deprivation as stress for female rats at weaning (three weeks old) and at adult age (two and a half months old). Triiodothyronine (T3) and histamine content of immune cells (lymphocytes, mast cells and monocyte-macrophage-granulocyte group in peritoneal fluid; lymphocytes, granulocytes and monocytes in blood; and lymphocytes in thymus) were studied three weeks after stress application using specific antibodies for flow cytometry and confocal microscopy. The stress at weaning increased T3 content of thymus lymphocytes. In case of adult T3, there was a cell type independent significant effect of stress, decreasing values in peritoneal fluid and slightly increasing effect in the blood. Histamine content of granulocytes was also significantly elevated. The experiments demonstrate that not only fetal or neonatal stress has long-lasting consequences, but also stress events in later periods of life in cells (organs) that are continuously differentiating. We will go on to discuss the importance of T3 and histamine in connection with stress and immunity.

Key words

Stress - T3 - histamine - hormonal imprinting - immunity

References

  • 1 Csaba G. Phylogeny and ontogeny of hormone receptors: the selection theory of receptor formation and hormonal imprinting.  Biol Rev. 1980;  55 47-63
    PubMedGoogle Scholar
  • 2 Csaba G. The present state in the phylogeny and ontogeny of hormone receptors.  Horm Metab Res. 1984;  16 329-335
    PubMedGoogle Scholar
  • 3 Csaba G. Phylogeny and ontogeny of chemical signaling: origin and development of hormone receptors.  Internat Rev Cytol. 1994;  155 1-48
    PubMedGoogle Scholar
  • 4 Csaba G. Interactions between the genetic programme and environmental influences in the perinatal critical period.  Zool Sci. 1991;  8 813-825
    PubMedGoogle Scholar
  • 5 Csaba G. Hormonal imprinting: its role during the evolution and development of hormones and receptors.  Cell Biol Int. 2000;  27 423-427
    PubMedGoogle Scholar
  • 6 Csaba G, Kovács P, Pállinger É. Effect of a single neonatal endorphin treatment on the hormone content of adult rat white blood cells and mast cells.  Cell Biol Int. 2003;  27 423-427
    CrossrefPubMedGoogle Scholar
  • 7 Csaba G, Kovács P, Pállinger É. Single treatment (hormonal imprinting) of newborn rats with serotonin increases the serotonin content of cells in adults.  Cell Biol Int. 2002;  26 663-668
    CrossrefPubMedGoogle Scholar
  • 8 Csaba G, Pállinger É. Prolonged impact of pubertal serotonin treatment (hormonal imprinting) on the later serotonin content of white blood cells.  Life Sci. 2002;  71 879-885
    CrossrefPubMedGoogle Scholar
  • 9 Csaba G, Kovács P, Pállinger É. Prolonged effect of a single serotonin treatment in adult age on the serotonin and histamine content of the white blood cells and mast cells of rat.  Cell Biochem Funct. 2003;  21 1-4
    CrossrefPubMedGoogle Scholar
  • 10 Csaba G, Karabélyos C, Inczefi-Gonda Á, Pállinger É. Three-generation investigation on serotonin content in rat immune cells long after β-endorphin exposure in late pregnancy.  Horm Metab Res; . 2005;  37 172-177
    Article in Thieme ConnectPubMedGoogle Scholar
  • 11 Sternberg W F, Ridgway C G. Effects of gestational stress and neonatal handling on pain, analgesia and stress behavior in adult mice.  Physiol Behav. 2003;  78 375-383
    CrossrefPubMedGoogle Scholar
  • 12 Anand K J. Effects of perinatal pain and stress.  Progr Brain Res. 2000;  122 117-129
    PubMedGoogle Scholar
  • 13 Maccari S, Darnaudery M, Morley-Fletcher S, Zuena A R, Cinque C, Van Reeth O. Prenatal stress and long-term consequences: implications of glucocorticoid hormones.  Neurosci Biobehav Rev. 2003;  27 119-127
    CrossrefPubMedGoogle Scholar
  • 14 Dorner G, Schenk B, Schmiedel B, Ahrens L. Stressful events in prenatal life of bi- and homosexual men.  Ex Clin Endocrinol. 2003;  81 83-87
    PubMedGoogle Scholar
  • 15 Insel T R, Kinsley C H, Mann P E, Bridges R S. Prenatal stress has long term effects on brain opiate receptors.  Brain Res. 1990;  511 93-97
    CrossrefPubMedGoogle Scholar
  • 16 Reznikov A G, Nosenko N D, Tarasenko L V, Sinitsyn P V, Polyakova L I. Early and long-term neuroendocrine effects of prenatal stress in male and female rats.  Neurosci Behav Physiol. 2001;  31 1-5
    CrossrefPubMedGoogle Scholar
  • 17 Weinstock M. Can the behaviour abnormalities induced by gestational stress in rats be prevented or reversed?.  Stress. 2002;  5 167-176
    PubMedGoogle Scholar
  • 18 Boksa P, El-Khodor B F. Birth insult interacts with stress at adulthood to alter dopaminergic function in animal models: possible implications for schizophrenia and other disorders.  Neurosci Biobehav Rev. 2003;  27 91-101
    CrossrefPubMedGoogle Scholar
  • 19 Csaba G, Kovács P, Pállinger É. Immunologically demonstrable hormone-like molecules (triiodothyronine, insulin, digoxin) in rat white blood cells and mast cells.  Cell Biol Int. 2004;  28 487-490
    CrossrefPubMedGoogle Scholar
  • 20 Csaba G, Kovács P, Pállinger É. Effect of the inhibition of triiodothyronine (T3) production by thiamazole on the T3 and serotonin content of immune cells.  Life Sci. 2005;  76 2043-2052
    CrossrefPubMedGoogle Scholar
  • 21 Williams M T, Davis H N, McCrea A E, Long S J, Hennessy M B. Changes in the hormonal concentrations of pregnant rats and their fetuses following multiple exposures to a stressor during the third trimester.  Neurotoxicol Terat. 1999;  21 403-414
    PubMedGoogle Scholar
  • 22 Goundasheva D, Andonova M, Ivanov V. Changes in some parameters of the immune response in rats after cold stress.  Zentralbl Veterinarmed B. 1994;  41 670-674
    PubMedGoogle Scholar
  • 23 van Haasteren G A, Linkels E, van Toor H, Klootwijk W, Kaptein E, de Jong F H, Reymond M J, Visser T J, deGreef W J. Effects of long-term food reduction on the hypothalamo-pituitary-thyroid axis in male and female rats.  J Endocrinol. 1996;  150 169-178
    CrossrefPubMedGoogle Scholar
  • 24 Wodzicka-Tomaszewska M, Stelmasiak T, Cumming R B. Stress by immobilization with food and water deprivation, causes changes in plasma concentration of triiodothyronine, thyroxine and corticosterone in poultry.  Austral J Biol Sci. 1982;  35 393-401
    PubMedGoogle Scholar
  • 25 van Doorn J, van der Heide D, Roelfsema F. The influence of partial food deprivation on the quantity and source of triiodothyronine in several tissues of athyreotic thyroxine-maintained rats.  Endocrinology. 1984;  115 705-711
    PubMedGoogle Scholar
  • 26 Connors J M, De-Vito W J, Hedge G A. Effects of food deprivation on the feedback regulation of the hypothalamic-pituitary-thyroid axis of the rat.  Endocrinology. 1985;  117 900-906
    PubMedGoogle Scholar
  • 27 Hugues J N, Enjalbert A, Burger A G, Voirol M J, Sebaoun J, Epelbaum J. Sensitivity of thyrotropin (TSH) secretion to 3,5,3'-triiodothyronine and TSH-releasing hormone in rat during starvation.  Endocrinology. 1986;  119 253-260
    PubMedGoogle Scholar
  • 28 Harris R B, Kasser T R, Martin R J. Dynamics of recovery of body composition after overfeeding, food restriction or starvation of mature female rats.  J Nutr. 1986;  116 2536-2546
    PubMedGoogle Scholar
  • 29 Oberkotter L V, Rasmussen K M. Changes in plasma thyroid hormone concentrations in chronically food restricted female rats and their offspring during suckling.  J Nutr. 1992;  122 435-441
    PubMedGoogle Scholar
  • 30 Rondeel J M, Heyde R, de Greef W J, van Toor H, van Haasteren G A, Klootwijk W, Visser T. Effect of starvation and subsequent refeeding on thyroid function and release of hypothylamic thyrotropin-releasing hormone.  Neuroendocrinology. 1992;  56 348-353
    PubMedGoogle Scholar
  • 31 Yen Y M, Distefano J J, Yamada H, Nguyen T T. Direct measurement of whole body thyroid hormone pool sizes and interconversion rates in fasted rats: hormone regulation and implications.  Endocrinology. 1994;  134 1700-1709
    CrossrefPubMedGoogle Scholar
  • 32 Blake N G, Johnson M R, Eckland D J, Foster O J, Lightman S L. Effect of food deprivation and altered thyroid status on the hypothalamic-pituitary-thyroid axis in the rat.  J Endocrinol. 1992;  133 183-188
    PubMedGoogle Scholar
  • 33 Ito C. The role of brain histamine in acute and chronic stresses.  Biomed Pharmacotherap. 2000;  54 263-267
    PubMedGoogle Scholar
  • 34 Brown R E, Stevens D R, Haas H L. The physiology of brain histamine.  Progr Neurobiol. 2001;  63 637-672
    CrossrefPubMedGoogle Scholar
  • 35 Carrasco G A, van de Kar L D. Neuroendocrine pharmacology of stress.  Eur J Pharmacol. 2003;  463 235-272
    CrossrefPubMedGoogle Scholar
  • 36 Knigge U, Warberg J. The role of histamine in the neuroendocrine regulation of pituitary hormone secretion.  Acta Endocrinol. 1991;  124 609-619
    PubMedGoogle Scholar
  • 37 Elenkov I J, Chrousos G P. Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity.  Ann NY Acad Sci. 2002;  966 290-303
    CrossrefPubMedGoogle Scholar
  • 38 Borysenko M, Borysenko J. Stress, behavior and immunity: animal models and mediating mechanisms.  Gen Hosp Psychiatr. 1982;  4 59-67
    PubMedGoogle Scholar
  • 39 de Kloet E R, Rots N Y, Cools A R. Brain-corticosteroid hormone dialogue: slow and persistent.  Cell Mol Neurobiol. 1996;  16 345-356
    CrossrefPubMedGoogle Scholar

György Csaba, M. D., Ph. D., D. Sc.

Department of Genetics, Cell and Immunobiology · Semmelweis University

POB 370 · 1445 Budapest · Hungary

Phone: +36 (1) 210 29 50 ·

Fax: +36 (1) 303 69 68

Email: csagyor@dgci.sote.hu

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