Erythema nodosum

W. Handrick; P. Nenoff; U. Paasch; C. Mügge; F. Berthold

doi:10.1055/s-2005-870277

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Aktuelle Dermatologie 2005; 31(11): 504-509
DOI: 10.1055/s-2005-870277

Übersicht

Erythema nodosum

Erythema nodosum - A ReviewW. Handrick¹ , P. Nenoff² , U. Paasch³ , C. Mügge² , F. Berthold⁴

¹Institut für Medizinische Diagnostik Berlin
²Laboratorium für medizinische Mikrobiologie, Partnerschaft Dr. J. Herrmann und PD Dr. P. Nenoff, Mölbis
³Klinik für Dermatologie, Allergologie und Venerologie, Universitätsklinikum Leipzig
⁴Ärztliches Labor Dr. Berthold & Kollegen, Frankfurt/Oder

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Publication History

Publication Date:
22 November 2005 (online)

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Zusammenfassung

Das Erythema nodosum ist ein entzündlicher Prozess im Bereich der Septen zwischen den subkutanen Fettläppchen, d. h. eine Pannikulitis, und wird als immunologische Reaktion auf unterschiedlichste antigenetische Stimuli aufgefasst.

In einer kurzen Übersicht werden die wichtigsten Aspekte der Epidemiologie, Ätiopathogenese, klinischen Symptomatik, Diagnostik, Differenzialdiagnostik und Therapie des Erythema nodosum dargestellt.

Abstract

Erythema nodosum is an inflammatory process in the lower layers of the dermis and in the septal portions of the subcutaneous fat tissue (panniculitis), representing an immune reaction to many different antigenic stimuli. The aim of this paper is to give a short review of epidemiology, etiopathology, clinical symptoms and signs, diagnostics, differential diagnosis and therapy of erythema nodosum.

Literatur

1 Anan T, Imamura T, Yokoyama S, Fujiwara S. Erythema nodosum and granulomatous lesions preceding acute myelomonocytic leukemia. J Dermatol. 2004; 31 741-747

MissingFormLabel
PubMed Search in Google Scholar
2 Barnard S, Marshall R, Parry R G, Johnston P. Sarcoid presenting with hypercalcaemia and erythema nodosum in a haemodialysis patient. Nephrol Dial Transplant. 2002; 17 175

MissingFormLabel
PubMed Search in Google Scholar
3 Bartyik K, Várkonyi A, Kirschner A, Endreffy E, Túri S, Karg E. Erythema nodosum in association with celiac disease. Pediatr Dermatol. 2004; 21 277-230

MissingFormLabel
Crossref PubMed Search in Google Scholar
4 Bohn S, Büchner S, Itin P. Erythema nodosum: 112 Fälle. Epidemiologie, Klinik und Histopathologie. Schweiz Med Wschr. 1997; 127 1168-1176

MissingFormLabel
PubMed Search in Google Scholar
5 Bonci A, Di Lernia V, Merli F, Lo Scocco G. Erythema nodosum and Hodgkin's disease. Clin Experim Dermatol. 2001; 26 408-411

MissingFormLabel
PubMed Search in Google Scholar
6 Boyd A S. Use of mycophenolate mofetil in erythema nodosum. J Am Acad Dermatol. 2002; 47 968-969

MissingFormLabel
Crossref PubMed Search in Google Scholar
7 Bridges A J, Graziano F M, Calhoun W, Reizner G T. Hyperpigmentation, neutrophilic alveolitis and erythema nodosum resulting from minocycline. J Am Acad Dermatol. 1990; 22 959-962

MissingFormLabel
PubMed Search in Google Scholar
8 Brodell R T, Mehrabi D. Underlying causes of erythema nodosum. Postgrad Med. 2000; 108 147-149

MissingFormLabel
PubMed Search in Google Scholar
9 Buckler J MH. Leptospirosis presenting with erythema nodosum. Arch Dis Childh. 1977; 52 418-419

MissingFormLabel
PubMed Search in Google Scholar
10 Calista D, Schianchi S, Morri M. Erythema nodosum induced by kerion celsi of the scalp. Pediatr Dermatol. 2001; 18 114-116

MissingFormLabel
Crossref PubMed Search in Google Scholar
11 Cancrini C, Angelici F, Colavita M, Cortis E, Chini L, Mammone F, Rossi P, De Sanctis R. Erythema nodosum: a presenting sign of early onset sarcoidosis. Clin Exp Rheumatol. 1998; 16 337-339

MissingFormLabel
PubMed Search in Google Scholar
12 Cascina A, Bianco A M, Mangiarotti P, Montecucco C M, Meloni F. Cutaneous vasculitis and reactive arthritis following respiratory infection due to Chlamydia pneumoniae: report of a case. Clin Experim Rheumatol. 2002; 20 845-847

MissingFormLabel
PubMed Search in Google Scholar
13 Cribier B, Caille A, Heid E, Grosshans E. Erythema nodosum and associated diseases. A study of 129 cases. Int J Dermatol. 1998; 37 667-672

MissingFormLabel
Crossref PubMed Search in Google Scholar
14 Erntell M, Ljunggren K, Gadd T, Persson K. Erythema nodosum - a manifestation of Chlamydia pneumoniae (strain TWAR) infection. Scand J Infect Dis. 1989; 21 693-696

MissingFormLabel
PubMed Search in Google Scholar
15 Farges C, de Lumley L, Piguet C, Gilbert B. Gastroentérite à Salmonella enteritidis et érythème nodeux. Arch Pédiatr. 1999; 6 337-338

MissingFormLabel
PubMed Search in Google Scholar
16 Fearfield L A, Bunker C B. Radiotherapy and erythema nodosum. Br J Dermatol. 2000; 142 189

MissingFormLabel
PubMed Search in Google Scholar
17 Folliot J P, Ducloux G. Erythème noueux à yersinia enterocolitica. Lille Méd. 1979; 24 39-40

MissingFormLabel
PubMed Search in Google Scholar
18 Foti C, Diaferio A, Daddabbo M, Angelini G. Tinea barbae associated with erythema nodosum in an immunocompetent man. J Eur Acad Dermatol Venerol. 2001; 15 250-251

MissingFormLabel
Crossref PubMed Search in Google Scholar
19 Garcia-Porrua C, Gonzalez-Gay M A, Vazquez-Caruncho M, Lopez-Lazaro L, Lueiro M, Fernandez M L, Alvarez-Ferreira J, Pujol R M. Erythema nodosum. Etiologic and predictive factors in a defined population. Arthr & Rheum. 2000; 43 584-592

MissingFormLabel
PubMed Search in Google Scholar
20 Garty B Z, Poznanski O. Erythema nodosum in Israeli children. Isr Med Assoc J. 2000; 2 145-146

MissingFormLabel
PubMed Search in Google Scholar
21 Gillot T J, Whallett A J, Struthers G R, Ilchyshyn A. Concurrent Sweet's syndrome (acute neutrophilic dermatosis), erythema nodosum and sarcoidosis. Clin Experim Dermatol. 1996; 22 54-56

MissingFormLabel
PubMed Search in Google Scholar
22 Gonzalez-Gay M A, Garcia Pourra C, Pujol R M, Salvarani C. Erythema nodosum: a clinical approach. Clin Exp Rheumatol. 2001; 19 365-368

MissingFormLabel
PubMed Search in Google Scholar
23 Graffin B, Genty I, Crétel E, Jean R, Drancourt M, Durand J M. Erythème noueux au cours d'une maladie des griffes du chat. Presse Méd. 2000; 29 1125

MissingFormLabel
PubMed Search in Google Scholar
24 Grunewald R W, Fiedler G M, Stöckmann F, Schauer A, Müller G A. Ungewöhnliche Diagnose bei rezidivierender Arthritis, Erythema nodosum und Herzrhythmusstörungen. Dtsch Med Wschr. 1997; 122 1516-1520

MissingFormLabel
PubMed Search in Google Scholar
25 Hassink R I, Pasquinelli C E, Jacomella V, Laux-End R, Bianchetti M G. Conditions currently associated with erythema nodosum in Swiss children. Eur J Pediatr. 1997; 156 851-853

MissingFormLabel
Crossref PubMed Search in Google Scholar
26 Haustein U F, Klug H. Ultrastrukturelle Untersuchung der Blutgefäße beim Erythema nodosum. Dermatol Monatsschr. 1977; 163 13-23

MissingFormLabel
PubMed Search in Google Scholar
27 Hyland-McGuire P, Guly H. Erythema nodosum - diagnostic difficulties in the accident and emergency department. J Accid Emerg Med. 1996; 13 211-212

MissingFormLabel
PubMed Search in Google Scholar
28 Kakourou T, Drosatou P, Psychou F, Aroni K, Nicolaidou P. Erythema nodosum in children: a prospective study. J Am Acad Dermatol. 2001; 44 17-21

MissingFormLabel
Crossref PubMed Search in Google Scholar
29 Karunakara B P, Maiya P P, Mallikarjuna H B. Childhood sarcoidosis presenting as recurrent erythema nodosum. Ind J Pediatr. 2002; 69 829

MissingFormLabel
PubMed Search in Google Scholar
30 Kirch W, Dührsen U. Erythema nodosum of dental origin. Clin Investig. 1992; 70 1073-1078

MissingFormLabel
PubMed Search in Google Scholar
31 Kumar S, Witzig T E, Rajkumar S V. Thalidomid: current role in the treatment of non-plasma cell malignancies. J Clin Oncol. 2004; 22 2477-2488

MissingFormLabel
Crossref PubMed Search in Google Scholar
32 Labbé L, Perel Y, Maleville J, Taieb A. Erythema nodosum in children: a study of 27 patients. Pediatr Dermatol. 1996; 13 447-450

MissingFormLabel
PubMed Search in Google Scholar
33 Lauhio A, Repo H, Nyberg M, Lähdevirta J. Erythema nodosum and conjunctivitis triggered by enteritis due to salmonella typhimurium. Scand J Infect Dis. 1988; 20 221-223

MissingFormLabel
PubMed Search in Google Scholar
34 Lentner A, Wrobel K, Frank J. Erythema nodosum als Primärmanifestation eines M. Behcet. Haut- u. Geschlechtskr. 1995; 70 448

MissingFormLabel
PubMed Search in Google Scholar
35 Lin T L, Chen P M, Huang D F, Kwang W K, Lo K, Wang W S. Erythema nodosum associated with carcinoid tumour. Clin and Exp Dermatol. 2004; 29 423-436

MissingFormLabel
PubMed Search in Google Scholar
36 Llorens-Terol J, Martinez-Roig A. Erythema nodosum associated with infectious mononucleosis. Helv Paediatr Acta. 1983; 38 91-94

MissingFormLabel
PubMed Search in Google Scholar
37 Longmore H JA. Toxoplasmosis and erythema nodosum. Br Med J. 1977; 1 490

MissingFormLabel
PubMed Search in Google Scholar
38 Louthrenoo W, Lertprasertsuke N, Kasitanon N, Sukitawut W. Erythema nodosum as a manifestation of HIV infection. Asian Pac J Allergy Immunol. 2002; 20 175-178

MissingFormLabel
PubMed Search in Google Scholar
39 Manckoundia P, Leveque L, Bonnotte B, Collet E, Lorcerie B. Infection à Mycobacterium avium intracellulare révélée par un érythème noueux. Presse Méd. 2001; 30 1552

MissingFormLabel
PubMed Search in Google Scholar
40 Mert A, Ozaras R, Tabak F, Ozturk R. Primary tuberculosis cases presenting with erythema nodosum. J Dermatol. 2004; 31 66-68

MissingFormLabel
PubMed Search in Google Scholar
41 Mert A, Ozaras R, Tabak F, Pekmezci S, Demirkesen C, Ozturk R. Erythema nodosum: an experience of 10 years. Scand J Infect Dis. 2004; 36 424-427

MissingFormLabel
PubMed Search in Google Scholar
42 Müller-Ladner U, Kaufmann R, Adler G, Scherbaum W A. Rezidivierendes Erythema nodosum nach Einnahme eines niedrig dosierten oralen Kontrazeptivums. Med Klin. 1994; 89 100-102

MissingFormLabel
PubMed Search in Google Scholar
43 Navarro J T, Ribera J M, Vaquero M, Tuset E, Junca J, Milla F, Feliu E. Erythema nodosum as a presenting feature of T-cell-rich B-cell lymphoma. Ann Hematol. 1995; 780 107-108

MissingFormLabel
PubMed Search in Google Scholar
44 Orchard T R, Chua C N, Ahmad T, Cheng H, Welsh K I, Jewell D P. Uveitis and erythema nodosum in inflammatory bowel disease: clinical features and the role of HLA genes. Gastroenterology. 2002; 123 714-718

MissingFormLabel
Crossref PubMed Search in Google Scholar
45 Peter R, Banyai T. Erythema nodosum revealing oculoglandular tularemia. Dermatology. 2001; 202 79-80

MissingFormLabel
Crossref PubMed Search in Google Scholar
46 Picco P, Gattorno M, Vignola S, Barabino A, Marazzi M G, Bondi E, Pistoia V, Buoncompagni A. Clinical and biological characteristics of immunopathological disease-related erythema nodosum in children. Scand J Rheumatol. 1999; 28 27-32

MissingFormLabel
Crossref PubMed Search in Google Scholar
47 Psychos D N, Voulgari P V, Skopouli F N, Drosos A A, Moutsopoulos H M. Erythema nodosum: the underlying conditions. Clin Rheumatol. 2000; 19 212-216

MissingFormLabel
Crossref PubMed Search in Google Scholar
48 Requena L, Requena C. Erythema nodosum. Dermatol Online J. 2002; 8 4

MissingFormLabel
PubMed Search in Google Scholar
49 Ricci R M, Deering K C. Erythema nodosum caused by omeprazole. Cutis. 1996; 57 434

MissingFormLabel
PubMed Search in Google Scholar
50 Ridder G J, Boedeker C C, Technau-Ihling K, Sander A. Cat-scartch disease: Otolaryngologic manifestations and management. Otolaryngol Head Neck Surg. 2005; 132 353-358

MissingFormLabel
Crossref PubMed Search in Google Scholar
51 Sanders C JG, Hulsmann R-F HJ. Persistent erythema nodosum and asymptomatic Campylobacter infection. J Am Acad Dermatol. 1991; 24 285-286

MissingFormLabel
PubMed Search in Google Scholar
52 Sarret C, Barbier C, Faucher R, Lacombe P, Meyer M, Labbé A. Erythema nodosum and adenopathy in a 15-year-old boy: uncommon signs of cat scratch disease. Arch Pédiad. 2005; 12 295-297

MissingFormLabel
PubMed Search in Google Scholar
53 Siriwardena A K. Erythema nodosum mimicking soft tissue sarcoma. Br J Clin Pract. 1990; 44 515-517

MissingFormLabel
PubMed Search in Google Scholar
54 Späthling S, Herzer P, Zöllner N. Erythema nodosum. Internist. 1992; 33 W11-W16

MissingFormLabel
PubMed Search in Google Scholar
55 Steiger U, Weber M. Ungewöhnliche Ursache von Erythema nodosum, Pleuraerguss und reaktiver Arthritis: Giardia lamblia. Schweiz Rundschr Med Prax. 2002; 91 1091-1092

MissingFormLabel
PubMed Search in Google Scholar
56 Stockmeger M. Erythema nodosum bei Sarkoidose Grad. 1. Praxis. 2000; 89 102-103

MissingFormLabel
PubMed Search in Google Scholar
57 Szeimies R M, Kaudewitz P, Braun-Falco O. Erythema nodosum und Non-Hodgkin-Lymphom. Hautarzt. 1992; 43 583-586

MissingFormLabel
PubMed Search in Google Scholar
58 Tan B B, Lear J T, Smith A G. Acne fulminans and erythema nodosum during isotretinoin therapy responding to dapsone. Clin Exper Dermatol. 1997; 22 26-27

MissingFormLabel
PubMed Search in Google Scholar
59 Teyssandier R, Guidet B, Pinta P, Offenstadt G. Pneumopathie à Mycoplasma pneumoniae avec anémie grave et érythème noueux. Presse Méd. 1985; 14 1613

MissingFormLabel
PubMed Search in Google Scholar
60 Vanbiervliet G, Anty R, Schneider S, Arab K, Rampal P, Hebuterne X. Traitement d'un syndrome de Sweet et d'un érythème noueux compliquant une maladie de Crohn par anti-TNFα (infliximab). Gastroenterol Clin Biol. 2002; 26 295-297

MissingFormLabel
PubMed Search in Google Scholar
61 Vazquez-Lopez F, Rippe M L, Soler T, Rodriguez A, Arribas J M, Perez-Oliva N. Erythema nodosum and acute Q fever: report of a case with granulomatous hepatitis and immunological abnormalities. Acta Derm Venereol. 1996; 77 73-74

MissingFormLabel
PubMed Search in Google Scholar
62 Villirillo A, Balsano L, Quinti S, Ughi C, Ventura A, Maggiore G. Erythema nodosum associated with Salmonella enteritidis infection. Pediatr Infect Dis J. 1995; 14 919-920

MissingFormLabel
PubMed Search in Google Scholar
63 Yamamoto T, Yokoyama A, Yamamoto Y, Mamada A. Erythema nodosum associated with Sjögren's syndrome. Br J Rheumatol. 1997; 36 707-708

MissingFormLabel
Crossref PubMed Search in Google Scholar
64 Yang S G, Han K H, Cho K H, Lee A- Y. Development of erythema nodosum in the course of oestrogen replacement therapy. Br J Dermatol. 1997; 137 319-320

MissingFormLabel
PubMed Search in Google Scholar

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