Re: Becker RHA, Frick AD, Burger F, Scholtz H, Potgleter JH: A Comparison of the Steady-State Pharmacokinetics and Pharmacodynamics of a Novel Rapid-Acting Insulin Analog, Insulin Glulisine and Regular Human Insulin in Healthy Volunteers Using the Euglycemic Clamp Technique

Page 1, Abstract, column two

We would like to make a correction to the Abstract, column two, as follows:

Previous incorrect paragraph: At steady state (90 - 120 min), insulin glulisine and RHI had equivalent glucose utilization (GIR-AUC_ss, 214 mg · kg^-1 for glulisine, 209 mg · kg^-1 for RHI) and infusion rates (GIR_ss, 1050 and 995 mg · min^-1 · kg^-1). Both insulins also presented equal total glucose disposal (GIR-AUC_{0 - clamp end}, 1050 and 995 mg · kg^-1) and onset of activity within 20 min.

Correct paragraph: At steady state (90 - 120 min), insulin glulisine and RHI had equivalent glucose utilization (GIR-AUC_ss, 209 mg · kg^-1 for glulisine, 214 mg · kg^-1 for RHI) and infusion rates (GIR_ss, 7.0 and 7.2 mg · kg^-1 · min^-1 ). Both insulins also presented equal total glucose disposal (GIR-AUC_{0 - clamp end}, 995 and 1050 mg · kg^-1) and onset of activity within 20 min.