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Synlett 2005(7): 1101-1104
DOI: 10.1055/s-2005-865198
DOI: 10.1055/s-2005-865198
LETTER
© Georg Thieme Verlag Stuttgart · New York
Copper-Catalyzed Etherification of Aryl Iodides Using KF/Al2O3: An Improved Protocol
Further Information
Received
24 September 2004
Publication Date:
14 April 2005 (online)
Publication History
Publication Date:
14 April 2005 (online)
Abstract
A simple and efficient method for the coupling of aryl iodides with aliphatic alcohols and phenols that does not require the use of alkoxide bases is described. This C-O bond forming procedure shows that the combination of air stable CuI and 1,10-phenanthroline in the presence of KF/Al2O3 comprises an extremely efficient and general catalyst system for the etherification of aryl iodides. Different functionalized aryl iodides were coupled with alcohols and phenols using this method.
Key words
etherification - aryl iodides - copper iodide - potassium fluoride on alumina - coupling reaction
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