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Pharmacopsychiatry 2005; 38(3): 139-143
DOI: 10.1055/s-2005-864126
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

The Intensity Dependence of Auditory Evoked ERP Components Predicts Responsiveness to Reboxetine Treatment in Major Depression

T. Linka1 , B. W. Müller1 , S. Bender1 , G. Sartory2 , M. Gastpar1
  • 1Clinic for Psychiatry and Psychotherapy, Rheinische Kliniken Essen, University of Duisburg-Essen, Essen, Germany
  • 2Department of Clinical Psychology, University of Wuppertal, Wuppertal, Germany
Further Information

Publication History

Received: 23.7.2004 Revised: 5.10.2004

Accepted: 15.11.2004

Publication Date:
18 May 2005 (online)

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Introduction: The intensity (loudness)-dependent amplitude change (IDAP) of auditory evoked event-related potential (ERP) components has been suggested as an indicator of central serotonergic neurotransmission. In patients with major depression, associations of high IDAP with favorable SSRI treatment outcome have been reported. This is the first study to assess the predictive value of the IDAP in SNRI treatment. Methods: We evaluated the pre-treatment intensity-dependent change of auditory evoked P1, N1, P2, and P1/N1 and N1/P2 peak-to-peak amplitudes in 14 inpatients with major depressive episode (DSM IV) in the course of 24 days of treatment with the SNRI reboxetine (6-12 mg/d). Results: Our data revealed a highly significant correlation between lower intensity-dependent N1 amplitude slopes prior to reboxetine treatment and stronger decrease of HDRS total score at Fz (r = 0.86, P < 0.001), Fcz (r = 0.91, P < 0.001), and Cz (r = 0.93, P < 0.001). Conclusion: This result corroborates the hypothesis of the IDAP as a differential indicator of serotonergic versus noradrenergic antidepressant psychopharmacotherapy.

References

  • 1 Beauducel A, Debener S, Brocke B, Kayser J. On the Reliability of Augmenting/Reducing.  J Psychophysiol. 2000;  14 (4) 226-240
    PubMedGoogle Scholar
  • 2 Beck A T, Ward C H, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression.  Arch Gen Psychiatry. 1961;  4 561-571
    CrossrefPubMedGoogle Scholar
  • 3 Brocke B, Beauducel A, John R, Debener S, Heilemann H. Sensation seeking and affective disorders: characteristics in the intensity dependence of acoustic evoked potentials.  Neuropsychobiology. 2000;  41 24-30
    PubMedGoogle Scholar
  • 4 Buchsbaum M, Silverman J. Stimulus intensity control and the cortical evoked response.  Psychosom Med. 1968;  30 12-22
    PubMedGoogle Scholar
  • 5 Croft R J, Klugman A, Baldeweg T, Gruzelier J H. Electrophysiological evidence of serotonergic impairment in long-term MDMA (”ecstasy”) users.  Am J Psychiatry. 2001;  158 1687-1692
    CrossrefPubMedGoogle Scholar
  • 6 Gallinat J, Bottlender R, Juckel G, Munke-Puchner A, Stotz G, Kuss H J, Mavrogiorgou P, Hegerl U. The loudness dependency of the auditory evoked N1/P2-component as a predictor of the acute SSRI response in depression.  Psychopharmacology (Berl). 2000;  148 404-411
    CrossrefPubMedGoogle Scholar
  • 7 Gallinat J, Senkowski D, Wernicke C, Juckel G, Becker I, Sander T, Smolka M, Hegerl U, Rommelspacher H, Winterer G, Herrmann W M. Allelic variants of the functional promoter polymorphism of the human serotonin transporter gene is associated with auditory cortical stimulus processing.  Neuropsychopharmacology. 2003;  28 530-532
    CrossrefPubMedGoogle Scholar
  • 8 Hamilton M. A rating scale for depression.  J Neurol Neurosurg Psychiatry. 1960;  23 56-62
    CrossrefPubMedGoogle Scholar
  • 9 Hegerl U, Bottlender R, Gallinat J, Kuss H J, Ackenheil M, Moller H J. The serotonin syndrome scale: first results on validity.  Eur Arch Psychiatry Clin Neurosci. 1998;  248 96-103
    CrossrefPubMedGoogle Scholar
  • 10 Hetzel G, Moeller O, Erfurth A, Michael N, Rothermundt M, Arolt V, Evers S. The impact of the selective monoamine reuptake inhibitors reboxetine and citalopram on visually-evoked event-related potentials in depressed patients.  Pharmacopsychiatry. 2004;  37 200-205
    Article in Thieme ConnectPubMedGoogle Scholar
  • 11 Juckel G, Hegerl U, Molnar M, Csepe V, Karmos G. Auditory evoked potentials reflect serotonergic neuronal activity - a study in behaving cats administered drugs acting on 5-HT1A autoreceptors in the dorsal raphe nucleus.  Neuropsychopharmacology. 1999;  21 710-716
    CrossrefPubMedGoogle Scholar
  • 12 Juckel G, Mavrogiorgou P, Bredemeier S, Gallinat J, Frodl T, Schulz C, Moller H J, Hegerl U. Loudness dependence of primary auditory-cortex-evoked activity as predictor of therapeutic outcome to prophylactic lithium treatment in affective disorders - a retrospective study.  Pharmacopsychiatry. 2004;  37 46-51
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 Kuenzel H E, Murck H, Held K, Ziegenbein M, Steiger A. Reboxetine induces similar sleep-EEG changes like SSRI's in patients with depression.  Pharmacopsychiatry. 2004;  37 193-195
    Article in Thieme ConnectPubMedGoogle Scholar
  • 14 Linka T, Müller B W, Bender S, Sartory G. The intensity dependence of the auditory evoked N1 component as a predictor to Citalopram treatment in patients with major depression. Neuroscience Letters 2004: in press
    Google Scholar
  • 15 Mulert C, Jager L, Pogarell O, Bussfeld P, Schmitt R, Juckel G, Hegerl U. Simultaneous ERP and event-related fMRI: focus on the time course of brain activity in target detection.  Methods Find Exp Clin Pharmacol. 2002;  24Suppl D 17-20
    PubMedGoogle Scholar
  • 16 (NIMH) N IoMH. CGI. Glinical global impressions. In: Bonato R, ed Manual for the EDCEU assessment battery,. 2nd edition Vol. 12 (R. Bonato, ed) NIMH, Chevy Chase; 1976
    Google Scholar
  • 17 Owens M J. Selectivity of antidepressants: from the monoamine hypothesis of depression to the SSRI revolution and beyond.  J Clin Psychiatry. 2004;  65 Suppl 4 5-10
    PubMedGoogle Scholar
  • 18 Paige S R, Fitzpatrick D F, Kline J P, Balogh S E, Hendricks S E. Event-related potential amplitude/intensity slopes predict response to antidepressants.  Neuropsychobiology. 1994;  30 197-201
    PubMedGoogle Scholar
  • 19 Proietti-Cecchini A, Afra J, Schoenen J. Intensity dependence of the cortical auditory evoked potentials as a surrogate marker of central nervous system serotonin transmission in man: demonstration of a central effect for the 5HT1B/1D agonist zolmitriptan (311C90, Zomig).  Cephalalgia. 1997;  17 849-854; discussion 799
    CrossrefPubMedGoogle Scholar
  • 20 Quednow B B, Kuhn K U, Stelzenmueller R, Hoenig K, Maier W, Wagner M. Effects of serotonergic and noradrenergic antidepressants on auditory startle response in patients with major depression. Psychopharmacology (Berl) 2004
    Google Scholar
  • 21 Semlitsch H V, Anderer P, Schuster P, Presslich O. A solution for reliable and valid reduction of ocular artifacts, applied to the P300 ERP.  Psychophysiology. 1986;  23 695-703
    CrossrefPubMedGoogle Scholar
  • 22 Strobel A, Debener S, Schmidt D, Hunnerkopf R, Lesch K P, Brocke B. Allelic variation in serotonin transporter function associated with the intensity dependence of the auditory evoked potential.  Am J Med Genet. 2003;  118B 41-47
    CrossrefPubMedGoogle Scholar
  • 23 Tuchtenhagen F, Daumann J, Norra C, Gobbele R, Becker S, Pelz S, Sass H, Buchner H, Gouzoulis-Mayfrank E. High intensity dependence of auditory evoked dipole source activity indicates decreased serotonergic activity in abstinent ecstasy (MDMA) users.  Neuropsychopharmacology. 2000;  22 608-617
    CrossrefPubMedGoogle Scholar
  • 24 von Knorring L, Johansson F. Changes in the augmenter-reducer tendency and in pain measures as a result of treatment with a serotonin-reuptake inhibitor - zimelidine.  Neuropsychobiology. 1980;  6 313-318
    PubMedGoogle Scholar
  • 25 von Knorring L, Perris C. Biochemistry of the augmenting-reducing response in visual evoked potentials.  Neuropsychobiology. 1981;  7 1-8
    PubMedGoogle Scholar
  • 26 Wang W, Timsit-Berthier M, Schoenen J. Intensity dependence of auditory evoked potentials is pronounced in migraine: an indication of cortical potentiation and low serotonergic neurotransmission?.  Neurology. 1996;  46 1404-1409
    CrossrefPubMedGoogle Scholar
  • 27 Yoshida K, Takahashi H, Higuchi H, Kamata M, Ito K, Sato K, Naito S, Shimizu T, Itoh K, Inoue K, Suzuki T, Nemeroff C B. Prediction of antidepressant response to milnacipran by norepinephrine transporter gene polymorphisms.  Am J Psychiatry. 2004;  161 1575-1580
    CrossrefPubMedGoogle Scholar

Thomas Linka, MD

Clinic for Psychiatry and Psychotherapy

University of Duisburg-Essen

Virchowstrasse 174

45147 Essen

Germany

Phone: +49 201 7227 226

Fax: +49 201 7227 303

Email: thomas.linka@uni-essen.de

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