Photodynamische Therapie bei aktinischen Keratosen und Morbus Bowen

Zusammenfassung

Die photodynamische Therapie mit topisch applizierter Aminolävulinsäure wurde vor mehr als einem Jahrzehnt zur Behandlung oberflächlicher kutaner Neoplasien in die Dermatologie eingeführt. In der Zwischenzeit liegen zahlreiche klinische Studien an Patienten mit aktinischen Keratosen und Morbus Bowen vor, welche die Wirksamkeit und hervorragenden kosmetischen Ergebnisse dieser neuen Therapieform dokumentieren. In Abhängigkeit von Zahl, Ausprägung und Lokalisation können langzeitige Remissionsraten von bis zu 90 % erzielt werden, weshalb die photodynamische Therapie heutzutage zu den vorrangigen Behandlungsoptionen für multiple aktinische Keratosen und Morbus Bowen gehört.

Abstract

In the early 90's photodynamic therapy with topically applied aminolevulinic acid has been introduced in dermatology as a new treatment modality for superficial skin tumors. Since that time numerous studies on patients with actinic keratosis and Bowen's disease have demonstrated the efficacy and excellent cosmetic results of this new therapeutic principle. Depending on number, severity and localization response rates of up to 90 % can be achieved. Therefore PDT is nowadays considered as one of the first line treatments for multiple actinic keratoses and Bowen's disease.

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