Radiologische Befunde bei inflammatorischen Pseudotumoren

Zusammenfassung

Inflammatorische Pseudotumoren sind seltene benigne Tumoren, die sowohl aus klinischer als auch radiologischer Sicht einen malignen Prozess imitieren können. Der Radiologe sollte mit dieser Tumorentität vertraut sein, um mitzuhelfen, unnötige radikale chirurgische Therapien zu vermeiden. Sie können in nahezu allen Organen vorkommen. Am häufigsten manifestieren sie sich jedoch in der Lunge und Orbita. Häufig ist zur Diagnosesicherung eine Biopsie notwendig. Für die Behandlung inflammatorischer Pseudotumoren stehen die chirurgische Entfernung, hoch dosierte Steroide, die Bestrahlung und die Chemotherapie als Therapieoptionen zur Verfügung.

Abstract

Inflammatory pseudotumor is a rare benign tumor entity. Because inflammatory pseudotumors mimic malignant tumors both clinically and radiologically, the radiologist should be familiar with this entity. Inflammatory pseudotumor most commonly involves the lung and the orbit, but it has been reported to occur in nearly every site in the body. For making a definite diagnosis a biopsy is often essential. The treatment options are varied and consist of surgery, high-dose steroids, irradiation, and chemotherapeutics.

Key words

Abdomen - heart - soft tissues - spleen - thorax - inflammatory pseudotumor

Literatur

• 1 Umiker W O, Iverson L C. Post inflammatory tumor of the lung: report of four cases simulating xanthoma, fibroma or plasma cell granuloma.  J Thorac Surg. 1954;  28 55-62
• 2 Scott L, Blair G, Taylor G. et al . Inflammatory pseudotumors in children.  J Pediatr Surg. 1988;  23 755-758
• 3 Hedlund G L. et al . Aggressive manifestation of inflammatory pulmonary pseudotumor in children.  Pediatr Radiol. 1999;  29 112-116
• 4 Agrons G A. et al . Pulmonary inflammatory pseudotumor: radiologic features.  Radiology. 1998;  206 511-518
• 5 Dehner L P. The engimatic inflammatory pseudotumors: the current state of our understanding, or misunderstanding (editorial).  J Pathol. 2000;  192 277-279
• 6 Maier H C, Sommers S C. Recurrent and metastatic pulmonary fibrous histiocytoma/plasma cell granuloma in a child.  Cancer. 1987;  60 1073-1076
• 7 Griffin C A, Haukins A L, Dvorack C. et al . Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors.  Cancer Res. 1999;  59 2776-2780
• 8 Wood C, Nickoloff B J, Todes-Taylor N R. Pseudotumor resulting from atypical mycobacterial infection: a „histoid” variety of Mycobacterium avium-intracellulare complex infection.  Am J Clin Pathol. 1985;  83 524-527
• 9 Maves C K, Johnson J F, Bove K. et al . Gastric inflammatory pseudotumor in children.  Radiology. 1989;  173 381-383
• 10 Slavotinek J P, Bourne A J, Sage M R. et al . Inflammatory pseudotumor of the pancreas in a child.  Pediatr Radiol. 2000;  30 801-803
• 11 Cohen M C, Kaschula ROC. Primary pulmonary tumors in childhood: a review of 31 years`experience and the literature.  Pediatr Pulmonol. 1992;  140 222-232
• 12 Patankar T, Prasad S, Shenoy A. et al . Pulmonary inflammatory pseudotumor in children.  Australas Radiol. 2000;  44 318-320
• 13 Coffin C M, Watterson J, Priest J R. et al . Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor): a clinicopathologic and immunohistochemical study of 84 cases.  Am J Surg Pathol. 1995;  19 859-872
• 14 Stark P, Sandbank J C, Rudnicki C. et al . Inflammatory pseudotumor of the heart with vasculitis and venous thrombosis.  Chest. 1992;  102 1884-1885
• 15 Jenkins P C, Dickison A E, Flanagan M F. Cardiac inflammatory pseudotumor: rapid appearance in an infant with congenital heart disease.  Pediatr Cardiol. 1996;  17 399-401
• 16 Rose A G, McCormick S, Cooper K. Titus JL. Inflammatory pseudotumor (plasma cell granuloma) of the heart.  Pathol Lab Med. 1996;  120 549-554
• 17 Narla L D, Siddiqi N H, Hingsbergen E A. Inflammatory pseudotumor of the right atrium.  Pediatr Radiol. 2001;  31 351-353
• 18 Chou P, Gonzalez-Crussi F, Cole R. et al . Plasma cell granuloma of the heart.  Cancer. 1988;  62 1409-1413
• 19 Estevao-Costa J, Corriera-Pinto J, Rodrigues F C. et al . Gastric inflammatory myofibroblastic proliferation in children.  Pediatr Surg Int. 1998;  13 95-99
• 20 Pack G T, Baker H W. Total right hepatectomy: report of a case.  Ann Surg. 1953;  138 253-258
• 21 Torzelli G, Inoue K, Midorikawa Y. et al . Inflammatory pseudotumors of the liver: prevalence and clinical impact in surgical patients.  Hepatogastroenterology. 2001;  48 1118-1123
• 22 Roth J A. Reactive pseudosarcomatous response in urinary bladder.  Urology. 1980;  16 633-637
• 23 Asanuma H, Nakai H, Shishido S. et al . Inflammatory pseudotumor of the bladder in neonates.  Int J Urol. 2000;  7 421-424
• 24 Inflammatory pseudotumor of the liver. Clinicopathologic study and review of the literature.  Cancer. 1990;  65 1583-1590
• 25 Levy S, Sauvanet A, Diebold M. et al . Spontaneous regression of an inflammatory pseudotumor of the liver presenting as an obstructing malignant biliary tumor.  Gastrointest Endosc. 2001;  53 371-374
• 26 Sanders B M, West K W, Gingalewski C. et al . Inflammatory pseudotumor of the alimentary tract: clinical and surgical experience.  J Pediatr Surg. 2001;  36 169-173
• 27 Martin C J. Orbital pseudotumor: case report and overview.  J Am Optom Assoc. 1997;  68 775-781
• 28 Harr D L, Qenier R M, AbramsGW. Computed tomography and ultrasound in the evaluation of orbital and infection and pseudotumors.  Radiology. 1982;  142 395-401
• 29 Heersink B, Rodriques M R, Flanagan J C. Inflammatory pseudotumor of the orbit.  Ann Ophthalmol. 1977;  9 17-29
• 30 Frohman L P, Kupersmith M L, Lang J. et al . Intracranial extension and bone destruction in orbital pseudotumor.  Arch Ophthalmol. 1986;  104 380-384
• 31 De Vuysere S, Hermans R, Sciot R. et al . Extraorbital inflammatory pseudotumor of the head and neck: CT and MR findings in three patients.  AJNR Am J Neuroradiol. 1999;  20 1133-1139
• 32 Ruaux C. et al . Inflammatory pseudotumor of the nasal cavity and sinuses.  J Laryngol Otol. 2001;  115 563-566
• 33 Hytiroglou P, Brandwein M S, Stauchen J A. et al . Inflammatory pseudotumor of the parapharyngeal space: case report and review of the literature.  Head Neck. 1992;  14 230-234
• 34 Lemke A J, Kazi I, Landeck M L. et al . Differenzialdiagnostik intrakonaler Raumforderungen unter Verwendung der hochauflösenden MRT mit Oberflächenspulen anhand von 78 Patienten.  Fortschr Röntgenstr. 2004;  176 1436-1446