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Rofo 2005; 177(7): 975-985
DOI: 10.1055/s-2005-858269
Experimentelle Radiologie

© Georg Thieme Verlag KG Stuttgart · New York

Homogene Strain-Analyse im Vergleich zur Wanddickenzunahme für die MR-tomographische Beurteilung der regionalen Myokardfunktion

Comparison of Homogenous Strain-Analysis with Wall Thickening for the Assessment of Regional Myocardial FunctionD. Thomas1 , S. Pickup1 , R. Zhou1 , J. Glickson1 , V. A. Ferrari1, 2
  • 1Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
  • 2Department of Medicine, Division of Cardiology, University of Pennsylvania
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Publication History

Publication Date:
22 June 2005 (online)

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Zusammenfassung

Ziel: Vergleich der Strain-Analyse mit der Analyse der Wanddickenzunahme (WDZ) zur Differenzierung der Infarktzone sowie des angrenzenden und entfernten Myokards in einem Ratteninfarktmodell. Material und Methoden: 3 normale (NL) und 10 Tiere mit induziertem Myokardinfarkt wurden an einem 4,7-T-Scanner untersucht. Gradienten-Echo- und SPAMM-Tagging-Cine-Sequenzen wurden in der kurzen Herzachse auf 3 verschiedenen Höhen des linken Ventrikels (LV) akquiriert. Eine homogene Strain-Analyse (Haupt-Strains λ1 und λ2, Verschiebung V, Winkel β) und eine Analyse der WDZ (mm- und %-WDZ) wurden für die Schichten, auf denen der Infarkt abgrenzbar war, durchgeführt. Die regionale Kontraktionsfunktion der infarzierten Tiere (infarziert, infarktangrenzend und entfernte Region) wurde mit korrespondierenden Regionen der NL-Ratten verglichen. Zusätzlich wurde für die NL-Tiere eine segmentale Analyse der anterioren, lateralen, inferioren und septalen Wand durchgeführt. Ergebnisse: Bei den NL-Ratten fand sich das größte λ1 (größte radiale Dickenzunahme des Myokards) in der lateralen und anterioren Wand. Die WDZ wies ein ähnliches Verteilungsmuster auf, allerdings waren die nachweisbaren Unterschiede nicht signifikant. λ2 (größte zirkumferentielle Verkürzung) wies den kleinsten Wert in der anterioren Wand auf. V war lateral und inferior am größten. Der Winkel β war in allen Segmenten radial ausgerichtet. Die Strain-Analyse und die WDZ der Infarkttiere zeigten eine Funktionsbeeinträchtigung der Infarktregion und des angrenzenden Myokards im Vergleich mit den NL-Tieren (p < 0,001). Eine signifikante Beeinträchtigung des entfernten Myokards wies jedoch nur die Strain-Analyse nach (λ1, λ2 mit p < 0,001). Es fanden sich signifikante Funktionsunterschiede zwischen der infarzierten und angrenzenden sowie infarzierten und entfernten Region. Die Strain-Analyse (λ2, V, β mit p < 0,001) wies darüber hinaus statistisch signifikante Unterschiede zwischen der angrenzenden und entfernten Region nach. Schlussfolgerung: Die Strain-Analyse ist der WDZ in der Detektion regionaler Funktionsunterschiede normaler Tiere sowie der Differenzierung der Funktion im infarzierten, angrenzenden und entfernten Myokard überlegen.

Abstract

Purpose: To compare strain analysis and wall thickening (WT) analysis in differentiating the infarcted, adjacent, and remote zones in a rat model of myocardial infarction (MI). Material and Methods: Three normal (NL) and ten rats subjected to myocardial infarction were imaged on a 4.7T scanner. Gradient-echo and SPAMM-tagged cine images were acquired at three short axis levels of the left ventricle (LV). A homogenous strain analysis (principal strains λ1 and λ2, displacement D, angle β) and a WT-analysis (mm- and %-thickening) were performed in all slices demonstrating MI. Regional function was compared between infarcted rats (infarcted, adjacent and remote zone) and corresponding regions in the NL rats. Additional segmental analysis was performed in the NL rats for the anterior, lateral, inferior and septal wall. Results: In the NL rats, λ1 (greatest radial thickening) was greatest in the lateral and anterior wall. WT-analysis showed a pattern of function similar to λ1, however, regional differences using WT-analysis were not significant. λ2 (greatest circumferential shortening) was most negative in the anterior wall. D was greatest in the lateral and inferior wall. The angle β was radially directed in all segments. In the infarcted rats, both strain and WT-analyses revealed significant impairment in function in the infarcted and adjacent zones as compared to NL (p < 0.001). However, only the strain analysis (λ1, λ2, p < 0.001) detected significant remote myocardial dysfunction. Myocardial function differed significantly between the infarcted and adjacent and between the infarcted and remote regions. Strain analysis (λ2, D, β, p < 0.001) also identified significant functional differences between the adjacent and remote zones, however, no statistically significant differences were found using WT-analysis. Conclusion: Strain analysis is superior to WT-analysis in detecting regional functional variations in NL rats and in discriminating function in the infarcted, adjacent and remote zones post MI.

Key words

Heart, MR - heart, infarction - MR, motion studies - MR-comparative studies - MR, experimental studies

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Dr. med. D. Thomas

University of Pennsylvania, Department of Radiology, B6 Blockley Hall

423 Guardian Drive

Philadelphia, PA 19104

Phone: ++ 1/2 15/7 46-87 52

Fax: ++ 1/2 15/7 46-87 64

Email: daniel.thomas@uphs.upenn.edu

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