Zusammenfassung
Wir berichten über den Fall eines 75-jährigen Mannes mit primärem malignen Malignom
der Speiseröhre, welches zunächst als anaplastisches Plattenepithelkarzinom diagnostiziert
worden war. Nach der Resektion des Tumors wurde ein amelanotisches malignes Melanom
mit deutlicher histologischer Heterogenität gesichert. Primäre maligne Melanome der
Speiseröhre sind sehr seltene Tumoren. Eine exakte präoperative Diagnose ist als Grundlage
für eine angemessene Therapie zu fordern. Klinische und pathologische Merkmale dieses
Falls werden vor dem Hintergrund der bestehenden Literatur diskutiert.
Abstract
We present the case of a primary malignant esophageal melanoma arising in a 75-year-old
male, initially diagnosed as anaplastic squamous cell carcinoma. After resection of
the tumor, histological work-up was indicative of a marked morphological heterogeneity,
resembling a focally amelanotic primary malignant melanoma. Primary malignant melanomas
of the esophagus are exceptionally rare. An exact preoperative diagnosis is critical
with respect to the appropriate therapeutic strategy. Clinicopathological features
of this entity with a brief review of the literature are presented.
Schlüsselwörter
Amelanotisch - Speiseröhre - HMB-45 - Melanom
Key words
Amelanotic - esophagus - HMB-45 - melanoma
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Jan Heidemann, M. D.
Department of Medicine B, University of Münster
Albert-Schweitzer-Str. 33
48129 Münster
Germany
Phone: ++ 49/2 51/8 34-80 01
Fax: ++ 49/2 51/8 34-75 76
Email: Jan_Heidemann@hotmail.com
