Planta Med 2005; 71(2): 108-113
DOI: 10.1055/s-2005-837775
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Mechanism of the Hypoglycemic Effect of Stevioside, a Glycoside of Stevia rebaudiana

Tso-Hsiao Chen1 , Shi-Chung Chen1 , Paul Chan1 , 2 , Yen-Ling Chu2 , Hung-Yu Yang1 , Juei-Tang Cheng3 , 4
  • 1Department of Medicine, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan
  • 2Clinical Research Center, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan
  • 3Traditional Chinese Medicine Research Center, National Cheng Kung University Medical College, Tainan, Taiwan
  • 4Department of Pharmacology, National Cheng Kung University Medical College, Tainan, Taiwan
Further Information

Publication History

Received: April 19, 2004

Accepted: August 21, 2004

Publication Date:
24 February 2005 (online)


We have studied the effects of stevioside on the glucose and insulin metabolism in 2 models of diabetes in rats, STZ-induced diabetic rats and NIDDM diabetic rats induced by feeding with fructose. Stevioside (0.5 mg/kg), lowered the blood glucose levels in STZ-induced diabetic rats, peaking at 90 min. Stevioside administered twice daily also demonstrated dose-dependent effects in lowering the glucose levels in both diabetic rat models. Stevioside reduced the rise in glucose during glucose tolerance testing in normal rats. Stevioside dose-dependently decreased protein levels of phosphoenol pyruvate carboxykinase (PEPCK) and PEPCK mRNA after 15 days of treatment. Stevioside also reduced insulin resistance in the diabetic animals as shown by the glucose lowering effects of tolbutamide. In conclusion, stevioside was able to regulate blood glucose levels by enhancing not only insulin secretion, but also insulin utilization in insulin-deficient rats; the latter was due to decreased PEPCK gene expression in rat liver by stevioside’s action of slowing down gluconeogenesis. Further studies of this agent for the treatment of diabetes appear warranted.


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Paul Chan, MD, PhD

Department of Medicine

Taipei Medical University - Wan Fang Hospital

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