Abstract
The inhibitory effects of 22 xanthones from three Guttiferae plants (Hypericum patulum, Calophyllum inophyllum and C. austroindium) on exogeneous platelet activating factor (PAF)-induced hypotension were examined
using a blood pressure monitoring in vivo assay method. Guanandin (2), caloxanthone E (3), 1,3,5,6-tetrahydroxy-2-isoprenylxanthone (8), 6-deoxyjacareubin (11) and patulone (18) showed strong inhibition of PAF-induced hypotension, with inhibitory effects of
more than 60 %. Their ID50 values were greater than that of ginkgolide B (BN-52 021), a natural PAF-antagonist
from the Ginkgo biloba.
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Dr. Kyoko Ishiguro
School of Pharmaceutical Sciences
Mukogawa Women’s University
Koshien Kyuban-cho
Nishinomiya 663-8179
Japan
Telefon: +81-798-45-9942
Fax: +81-798-45-9942
