Semin Liver Dis 2004; 24(4): 415-419
DOI: 10.1055/s-2004-860870
DIAGNOSTIC PROBLEMS IN HEPATOLOGY

Copyright © 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Obesity as a Risk Factor for Hepatocellular Carcinoma in a Noncirrhotic Patient

Laurent Gonzalez1 , Jean Frédéric Blanc1 , Antonio Sa Cunha1 , Anne Rullier1 , Jean Saric1 , Brigitte Le Bail1 , Charles Balabaud1 , Paulette Bioulac-Sage1
  • 1Fédération des spécialités digestives, CHU Bordeaux and GREF, Université Bordeaux 2, Bordeaux, France
Further Information

Publication History

Publication Date:
16 December 2004 (online)

Preview

Obesity places people at risk of developing cirrhosis.[1] [2] [3] A subset of patients with cryptogenic cirrhosis had not only a history of overweight, but also a wide range of overweight-related metabolic features such as diabetes, dyslipidemia, and high-serum ferritin, which define insulin resistance. A high incidence of liver cancer in obese patients with cryptogenic cirrhosis was reported recently.[1] [4] [5] The underlying metabolic abnormalities defining or associated with an obesity-related insulin-resistant state could promote carcinogenesis, irrespective of the presence of cirrhosis. Here we report a case that may support this hypothesis.

REFERENCES

 Dr.
Paulette Bioulac-Sage

GREF Inserm 0362 Université Bordeaux 2

Bordeaux, France

Email: paulette.bioulac-sage@gref.u-bordeaux2.fr