Zusammenfassung
Etwa 20-25 % aller Patienten mit Herz-Kreislauf-Erkrankungen leiden gleichzeitig an
Depressionen. Depressive Erkrankungen erhöhen das kardiovaskuläre Morbiditäts- und
Mortalitätsrisiko. Vieles spricht für eine multikausale Interaktion zwischen depressiven
und kardiovaskulären Erkrankungen; neben genetischen Faktoren werden endokrine, neurokardiologische,
metabolische und behaviorale Faktoren diskutiert. Obwohl Depressionen überzufällig
häufig ältere und multimorbide Patienten betreffen, werden sie in der klinischen Praxis
nur bei etwa der Hälfte dieser Patienten korrekt diagnostiziert, und selbst im Falle
einer korrekten Diagnose zumeist nur unzureichend behandelt. Die meisten dieser Patienten
werden primär nicht von Psychiatern, sondern von Ärzten anderer Fachrichtungen betreut.
In Anbetracht der signifikanten Interaktion zwischen depressiven und kardiovaskulären
Erkrankungen ist eine engmaschige Vernetzung aller am Behandlungsprozess beteiligten
Arztgruppen nicht zuletzt auch aus ökonomischen Gründen zur Vermeidung von Folgekosten
zwingend notwendig.
Summary
Some 20-25 % of all patients with cardiovascular diseases simultaneously suffer from
depression. Depressive diseases increase the cardiovascular morbidity and mortality
risk. There is much evidence for a multicausal interaction between depressive and
cardiovascular diseases; apart from genetic factors, endocrine, neurocardiological,
metabolic and behavioural factors are under discussion. Although depression is found
disproportionately often in the elderly and multimorbid patient, it is correctly diagnosed
in only about one-half of these patients, and even when correctly diagnosed, is usually
inadequately treated. Most of these patients are under the care not of psychiatrists,
but other specialists. In light of the significant interaction between depressive
and cardiovascular diseases, close cooperation of all the physicians involved in the
management process is urgently mandated, not least for economic reasons to avoid follow-up
costs.
Key Words:
depression - cardiovascular disease - affective illness
Literatur
- 1
Agelink MW, Boz C, Ullrich H, Andrich J.
Relationship between major depression and heart rate variability: clinical consequences
and implications for antidepressive treatment.
Psychiatry Res.
2002;
113
139-149
- 2
Agelink MW, Majewski T, Wurthmann C. et al. .
Autonomic neurocardiac function in patients with major depression and effects of antidepressive
treatment with nefazodone.
J Affect Dis.
2001;
62
187-198
- 3
Anda R, Williamson D, Jones D. et al. .
Depressed affect, hopelessness, and the risk of ischemic heart disease in a cohort
of US adults.
Epidemiology.
1993;
4
285-294
- 4
Barefoot JC, Schroll M.
Symptoms of depression, acute myocardial infarction, and total mortality in a community
sample.
Circulation.
1996;
93
1976-1980
- 5
Ben-David J, Zipes DP.
Autonomic neural modulation of cardiac rhythm: Part I. Basic concepts.
Modern Concepts of Cardiovascular Disease.
1988;
57
41-46
- 6
Blumenthal JA, Williams RS, Wallace AG, Williams RB, Needles TL.
Physiological and psychological variables predict compliance to prescribed exercise
therapy in patients recovering from myocardial infarction.
Psychosom Med.
1982;
44
519-527
- 7
Bondy B, Baghai TC, Zill P. et al. .
Combined action of the ACE D- and the G-protein beta-3-T-allele in major depression:
a possible link to cardiovascular disease?.
Mol Psychiatry.
2002;
7
1120-1126
- 8
Carney RM, Rich MW, teVelde A, Saini J, Clark K, Jaffe AS.
Major depressive disorder in coronary artery disease.
Am J Cardiol.
1987;
60
1273-1275
- 9
Comings DE, McMurray JP, Gonzales N, Ferry L, Peters WR.
Association of the serotonin transporter gene with serum cholesterol levels and heart
disease.
Mol Genet Metab.
1999;
67
248-253
- 10
Coryell W, Turvey C, Leon A. et al. .
Persistance of depressive symptoms and cardio-vascular death among patients with affective
disorder.
Psychosom Med.
1999;
61
755-761
- 11
Davidson K, Jonas BS, Dixon E, Markowitz JH.
Do depression symptoms predict early hypertension - incidence in young adults in the
CARDIA study.
Arch Intern Med.
2000;
160
1495-1500
- 12
Everson SA, Goldberg DE, Kaplan GA, Cohen RD, Pukkala E, Tuomilehto J, Salonen JT.
Hopelessness and risk of mortality and incidence of myocardiale infarction and cancer.
Psychosom Med.
1996;
58
113-121
- 13
Ferketich AK, Schwartzbaum JA, Frid DJ, Moeschberger ML.
Depression as an antecedent to heart disease among women and men in the NHANES I study.
Arch Intern Med.
2000;
160
1261-1268
- 14
Ford DE, Mead LA, Chang PP, Cooper-Patrick L, Wang NY, Klag MJ.
Depression is a risk factor for coronary artery disease in men.
Arch Intern Med.
1998;
158
1422-1426
- 15
Frasure-Smith N, Lesperance F, Talajic M.
Depression and 18-month prognosis after myocardial infarction.
Circulation.
1995;
91
999-1005
- 16
Frasure-Smith N, Lesperance F, Talajic M.
Depression following myocardial infarction: impact on 6-month survival.
JAMA.
1993;
270
1819-1861
- 17
Glassman AH, Shapiro PA.
Depression and the course of coronary artery disease.
Am J Psychiatr.
1998;
155
4-11
- 18
Goldberg EL, Comstock GW, Hornstra RK.
Depressed mood and subsequent physical illness.
Am J Psychiatr.
1979;
136
530-534
- 19
Hayward C.
Psychiatric illness and cardiovascular disease risk.
Epidemiol Rev.
1995;
17
129-138
- 20
Herrmann C, Brand-Driehorts S, Buss U, Rüger U.
Effects of anxiety and depression on 5-year mortality in 5057 patients referred for
exercise testing.
J Psychosom Res.
2000;
48
455-462
- 21
Heßlinger B, Härter M, Barth J. et al. .
Komorbidität von depressiven Störungen und kardiovaskulären Erkrankungen.
Nervenarzt.
2002;
73
205-218
- 22
Jiang W, Babyak M, Krantz DS. et al. .
Mental stress-induced myocardial ischemia and cardiac events.
JAMA.
1996;
275
1651-1656
- 23
Kannel WB, Kannel C, Paffenbarger RS, Cupples LA.
Heart rate and cardiovascular mortality: The Framingham Study.
Am Heart J.
1987;
113
1489-1494
- 24
Kittayaphong R, Cascio WE, Light KC. et al. .
Heart rate variability in patients with coronary artery disease: Differences in patients
with higher and lower depression scores.
Psychosom Med.
1997;
59
231-235
- 25
Lake CR, Pickar D, Ziegler MG, Lipper S, Slater S, Murphy DL.
High plasma norepinephrine levels in patients with major affective disorder.
Am J Psychiatry.
1982;
139
1315-1318
- 26
Lederbogen F, Gilles M, Maras A. et al. .
Increased platelet aggregability in major depression.
Psychiatry Res.
2001;
102
255-261
- 27
Lesperance F, Frasure-Smith N, Juneau M, Theroux P.
Depression and 1-year prognosis in unstable angina.
Arch Intern Med.
2000;
160
1354-1360
- 28
Light KC, Kothandapani RV, Allen MT.
Enhanced cardiovascular and catecholamine responses in women with depressive symptoms.
Int J Psychophysiol.
1998;
28
157-166
- 29
Linden M, Kurtz G, Baltes MM. et al. .
Depression in the very elderly.
Nervenarzt.
1998;
69
27-37
- 30
Lown B, Verrier RL, Rabinowitz SH.
Neural and psychologic mechanisms and the problem of sudden cardiac death.
Am J Cardiol.
1977;
39
890-902
- 31
Lown B, Verrier RL.
Neural activity and ventricular fibrillation.
N Engl J Med.
1976;
294
1165-1170
- 32
Maes M, Smith R, Christophe A. et al. .
Lower serum high-density lipoprotein cholesterol (HDL) in major depression and in
depressed men with serious suicidal attempts: relationship with immune-inflammatory
markers.
Acta Psychiatr Scand.
1997;
95
212-221
- 33
Malzberg B.
Mortality among patients with in involution melancholia.
Am J Psychiatr.
1937;
93
1231-1238
- 34
Meredith IT, Broughton A, Jennings GL, Esler MD.
Evidence of a selective increase in cardiac sympathetic activity in patients with
sustained ventricular arrhythmias.
N Eng J Med.
1991;
325
618-624
- 35
Musselman DL, Evans DL, Nemeroff CB.
The relationship of depression to cardiovascular disease. Epidemiology, biology and
treatment.
Arch Gen Psychiatr.
1998;
55
580-592
- 36
Penninx BWJH, Beckman ATF, Honig A. et al. .
Depression and cardiac mortality.
Arch Gen Psychiatr.
1991;
58
221-227
- 37
Pratt LA, Ford DE, Crum RM, Armenian HK, Gallo J, Eaton WW.
Depression, psychotropic medication and risk of myocardial infarction.
Circulation.
1996;
94
3123-3129
- 38
Rechlin T, Weis M, Spitzer A, Kaschka WP.
Are affective disorders associated with alterations of heart rate variability?.
J Affect Dis.
1994;
32
271-275
- 39
Roose SP, Yeragani V.
Antidepressants and mortality in depressed patients with concomitant illness.
Eur Neuropsychopharmacol.
2002;
12
S162
- 40
Schleifer SJ, Macari-Hinson MM, Coyle DA. et al. .
The nature and course of depression follwing myocardial infarction.
Arch Intern Med.
1989;
149
1785-1789
- 41
Schwartz PJ, La MT Rovere, Vanoli E.
Autonomic nervous system and sudden cardiac death. Experimental basis and clinical
observations for post myocardial infarction risk stratification.
Circulation.
1992;
85
177-191
- 42
Severus WE, Littman AB, Stoll AL.
Omega-3 fatty acids, homocysteine, and increased risk of cardiovascular mortality
in major depressive disorder.
Harv Rev Psychiatry.
2001;
9
280-293
- 43
Stein PK, Carney RM, Freedland KE. et al. .
Severe depression is associated with markedly reduced heart rate variability in patients
with stable coronary heart disease.
J Psychosom Res.
2000;
48
493-500
- 44
Berkman LF, Blumenthal J, Burg M. et al. .
Study Group Of Enhancing Recovery In Coronary Heart Disease Patients. Effects of treating
depression and low perceived social support on clinical events after myocardial infarction:
the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial.
JAMA.
2003;
289
3106-3116
- 45
Verrier RL, Calvert A, Lown B.
Effect of posterior hypothalamic stimulation on ventricular fibrillation threshold.
Am J Physiol.
1975;
228
923-927
- 46
Vogt T, Pope C, Mullooly J, Hollis J.
Mental health status as a predictor of morbidity and mortality: a 15-year follow-up
of members of a health maintenance organization.
Am J Public Health.
1994;
84
227-231
- 47
Wenzel RR, Siffert W, Bruck H, Philipp T, Schafers RF.
Enhanced vasoconstriction to endothelin-1, angiotensin II and noradrenaline in carriers
of the GNB3 825T allele in the skin microcirculation.
Pharmacogenetics.
2002;
12
489-495
- 48
Wetterling T, Junghanns K.
Gerontopsychiatrischer Konsiliardienst.
Psychiatr Prax.
2002;
29
311-314
- 49
Whyte EM, Pollock BG, Wagner WR. et al. .
Influence of serotonin transporter promotor region polymorphism on patelet activation
in geriatric depression.
Am J Psychiatry.
2001;
158
2074-2076
- 50
Zaza A, Schwartz PJ.
Role of the autonomic nervous system in the genesis of early ischemic arrhythmias.
J Cardiovasc Pharmacol.
1985;
7
S8-S12
Korrespondenzadresse:
Dr. Marcus W. Agelink
Institut für Biologische Psychiatrie und Klinik für Psychiatrie, Psychotherapie und
Psychosomatik
Evanglische Kliniken Gelsenkirchen
Ruhr Universität Bochum
45879 Gelsenkirchen