Planta Med 2004; 70(11): 1027-1032
DOI: 10.1055/s-2004-832642
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Anti-Inflammatory and Antinociceptive Effects of Sinapyl Alcohol and its Glucoside Syringin

Jongwon Choi1 , Kyoung-Min Shin2 , Hee-Juhn Park3 , Hyun-Ju Jung3 , Hyoung Ja Kim4 , Yong Sup Lee4 , Jae-Hwan Rew5 , Kyung-Tae Lee2
  • 1College of Pharmacy, Kyungsung University, Pusan, Korea
  • 2College of Pharmacy, Kyunghee University, Seoul, Korea
  • 3Division of Applied Plant Sciences, Sangji University, Wonju, Korea
  • 4Division of Life Sciences, Korea Institute of Science and Technology, Seoul, Korea
  • 5College of Oriental Medicine, Kyung Hee University, Seoul, Korea
Further Information

Publication History

Received: March 5, 2004

Accepted: June 4, 2004

Publication Date:
18 November 2004 (online)

Abstract

In the present study, syringin, isolated by activity-guided fractionation of the ethyl acetate (EtOAc) extracts of the stem bark of Magnolia sieboldii, and sinapyl alcohol, the hydrolysate of syringin, were evaluated for anti-inflammatory and antinociceptive activities. Sinapyl alcohol (20, 30 mg/kg/day, p. o.) inhibited increased vascular permeability by acetic acid in mice and reduced acute paw edema by carrageenan in rats more so than syringin. When analgesic activity was measured using the acetic acid-induced writhing test and the hot plate test, sinapyl alcohol was much more potent than syringin in a mouse model. In addition, sinapyl alcohol more potently inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E2 (PGE2), and tumor necrosis factor (TNF)-α production by macrophages than syringin. Consistent with these observations, the expression levels of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 was reduced by sinapyl alcohol in a concentration-dependent manner. These results suggest that the anti-inflammatory and antinociceptive effects of syringin after oral administration may be attributed to its in vivo transformation to sinapyl alcohol.

References

Dr. Kyung-Tae Lee

Department of Biochemistry

College of Pharmacy

Kyunghee University

Dongdaemun-Ku

Hoegi-Dong 130-701

Seoul

Korea

Phone: +82-2-961-0860

Fax: +82-2-966-3885

Email: ktlee@khu.ac.kr

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