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Synthesis 2004(16): 2760-2765  
DOI: 10.1055/s-2004-831164
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© Georg Thieme Verlag Stuttgart · New York

Cyanoacetylation of Indoles, Pyrroles and Aromatic Amines with the Combination Cyanoacetic Acid and Acetic Anhydride

Johnny Slätt, Ivan Romero, Jan Bergman*
Unit for Organic Chemistry, Department of Biosciences, Karolinska Institute and Södertörn University College, Novum Research Park, 141 57 Huddinge, Sweden
Fax: +46(8)6089204; e-Mail: jabe@cnt.ki.se ;
Further Information

Publication History

Received 1 March 2004
Publication Date:
13 August 2004 (online)

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Abstract

Cyanoacetic acid was activated with acetic anhydride and when heated this reagent reacted with a variety of both activated and deactivated pyrroles, indoles and aniline derivatives.

Key words

acylations - electrophilic aromatic substitutions - heterocycles - indoles - pyrroles

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Slätt, J.; Bergman, J., unpublished results.