Zusammenfassung
Mehr als 30 % aller stationären Aufnahmen in einer urologischen Klinik erfolgen zur
Behandlung von Harnsteinen. Die Therapie erfolgt heute in fast allen Fällen minimalinvasiv
durch extrakorporale Stoßwellenlithotripsie (ESWL), Ureterorenoskopie (URS) oder perkutane
Nephrolithotomie (PCNL). Technische Weiterentwicklungen in der Endourologie und gewachsene
Erfahrung mit der ESWL haben in den letzten Jahren zu einem Rückgang der ESWL-Behandlungen
und einem häufigeren Einsatz endoskopischer Techniken geführt. Diese sind zwar im
Vergleich zur ESWL invasiver, führen jedoch in den meisten Fällen zu einer rascheren
Steinfreiheit. Durch die Einführung des Fallpauschalensystems (DRGs) wird auch die
ökonomische Seite der Steintherapie immer wichtiger werden. Steinprävention führt
zu einer Kostenreduktion im Gesundheitswesen, weshalb eine geeignete Steinmetaphylaxe
durchgeführt werden sollte. Die vorliegende Übersichtsarbeit stellt daher die aktuellen
Therapieempfehlungen der interventionellen Harnsteintherapie und Steinmetaphylaxe
dar und zeigt Möglichkeiten auf, eine sowohl medizinisch als auch ökonomisch rationale
Therapie durchzuführen.
Abstract
More than 30 % of all admissions to an urologic clinic are for the treatment of urinary
stones. In almost all cases, the treatment is minimally invasive employing extracorporeal
shock wave lithotripsy (ESWL), ureterorenoscopy (URS) or percutaneous nephrolithotomy
(PCNL). Technical advances in endourology and a growing expertise in ESWL led to a
decline in ESWL and an increase in endoscopic techniques. In comparison with ESWL,
the endoscopic techniques are more invasive but in most cases achieve a stone free
state faster. With the introduction of diagnosis related groups (DRG), the economic
aspect of stone therapy is gaining in importance. Stone prevention leads to a cost
reduction in the health care system, justifying the use of an appropriate stone metaphylaxis.
This review article presents the current recommendations for interventional urinary
stone therapy and lists the options of conducting both medical and economically rational
therapy.
Schlüsselwörter
Harnsteine - extrakorporale Stoßwellenlithotripsie (ESWL) - Ureterorenoskopie (URS)
- perkutane Nephrolithotomie (PCNL) - Fallpauschalensystem (DRG) - Kostenreduktion
Key words
Urinary stones - extracorporeal shock wave lithotripsy (ESWL) - ureterorenoscopy (URS)
- percutaneous nephrolithotomy (PCNL) - diagnosis related groups (DRG) - cost reduction
Literatur
- 1
Tiselius H G, Ackermann D, Alken P, Buck C, Conort P, Gallucci M.
Guidelines on urolithiasis.
Eur Urol.
2001;
40 (4)
362-371
- 2
Tiselius H G.
Possibilities for preventing recurrent calcium stone formation: principles for the
metabolic evaluation of patients with calcium stone disease.
BJU Int.
2001;
88 (2)
158-168
- 3
Brandle E, Hautmann R, Alken P, Hesse A, Schafer R, Richter-Reichhelm M. et al .
Metaphylaxis of urinary calculi.
Urologe A.
1997;
36 (6)
588-593
- 4
Rochell B, Roeder N.
DRG: the new hospital reimbursement system for Germany. Part 1: Introduction.
Urologe A.
2003;
42 (4)
471-484
- 5
Knoll T, Michel M S, Kohrmann K U, Alken P.
Urologic interventional therapy of kidney calculi (I)-extracorporeal shockwave lithotripsy.
Ther Umsch.
2003;
60 (2)
98-102
- 6
Brandle E, Hautmann R, Alken P, Hesse A, Schafer R, Richter-Reichhelm M. et al .
Techniques for interventional and operative therapy of calculi.
Urologe A.
1997;
36 (6)
585-587
- 7
Brandle E, Hautmann R, Alken P, Hesse A, Schafer R, Richter-Reichhelm M. et al .
Indication for therapy in urinary calculi.
Urologe A.
1997;
36 (6)
582-584
- 8
Lingeman J E, Kim S C, Kuo R L, McAteer J A, Evan A P.
Shockwave lithotripsy: anecdotes and insights.
J Endourol.
2003;
17 (9)
687-693
- 9
Evan A P, Willis L R, Lingeman J E, McAteer J A.
Renal trauma and the risk of long-term complications in shock wave lithotripsy.
Nephron.
1998;
78 (1)
1-8
- 10
Lingeman J E, Woods J, Toth P D, Evan A P, McAteer J A.
The role of lithotripsy and its side effects.
J Urol.
1989;
141 (3 Pt 2)
793-797
- 11
Chan S L, Stothers L, Rowley A, Perler Z, Taylor W, Sullivan L D.
A prospective trial comparing the efficacy and complications of the modified Dornier
HM3 and MFL 5000 lithotriptors for solitary renal calculi.
J Urol.
1995;
153 (6)
1794-1797
- 12
Kohrmann K U, Rassweiler J J, Manning M, Mohr G, Henkel T O, Junemann K P. et al .
The clinical introduction of a third generation lithotriptor: Modulith SL 20.
J Urol.
1995;
153 (5)
1379-1383
- 13
Haecker A, Hatzinger M, Knoll T, Leistner R, Wendt-Nordahl G, Michel M S, Marlinghaus E,
Alken P, Koehrmann K U.
Ex-vivo evaluation of renal injury of a new electromagnetic shockwave generation with
user selectable dual focus size data.
J Urol.
2004;
171
1874
- 14
Segura J W, Preminger G M, Assimos D G, Dretler S P, Kahn R I, Lingeman J E. et al
.
Ureteral Stones Clinical Guidelines Panel summary report on the management of ureteral
calculi. The American Urological Association.
J Urol.
1997;
158 (5)
1915-1921
- 15
Muslumanoglu A Y, Tefekli A, Sarilar O, Binbay M, Altunrende F, Ozkuvanci U.
Extracorporeal shock wave lithotripsy as first line treatment alternative for urinary
tract stones in children: a large scale retrospective analysis.
J Urol.
2003;
170 (6 Pt 1)
2405-2408
- 16
Landau E H, Gofrit O N, Shapiro A, Meretyk S, Katz G, Shenfeld O Z. et al .
Extracorporeal shock wave lithotripsy is highly effective for ureteral calculi in
children.
J Urol.
2001;
165 (6 Pt 2)
2316-2319
- 17
Knoll T, Michel M S, Alken P.
Interventional treatment of urinary calculi.
Dtsch Med Wochenschr.
2003;
128 (27)
1485-1488
- 18
Anagnostou T, Tolley D.
Management of ureteric stones.
Eur Urol.
2004;
45 (6)
714-721
- 19
Bagley D H, Kuo R L, Zeltser I S.
An update on ureteroscopic instrumentation for the treatment of urolithiasis.
Curr Opin Urol.
2004;
14 (2)
99-106
- 20
Elashry O M, Elbahnasy A M, Rao G S, Nakada S Y, Clayman R V.
Flexible ureteroscopy: Washington University experience with the 9.3F and 7.5F flexible
ureteroscopes.
J Urol.
1997;
157 (6)
2074-2080
- 21
Menezes P, Dickinson A, Timoney A G.
Flexible ureterorenoscopy for the treatment of refractory upper urinary tract stones.
BJU Int.
1999;
84 (3)
257-260
- 22
Troy A J, Anagnostou T, Tolley D A.
Flexible upper tract endoscopy.
BJU Int.
2004;
93 (5)
671-679
- 23
Chiu K Y, Cai Y, Marcovich R, Smith A D, Lee B R.
Are new-generation flexible ureteroscopes better than their predecessors?.
BJU Int.
2004;
93 (1)
115-119
- 24
Shvarts O, Perry K T, Goff B, Schulam P G.
Improved functional deflection with a dual-deflection flexible ureteroscope.
J Endourol.
2004;
18 (2)
141-144
- 25
Collins J W, Keeley Jr F X, Timoney A.
Cost analysis of flexible ureterorenoscopy.
BJU Int.
2004;
93 (7)
1023-1026
- 26
Delvecchio F C, Preminger G M.
Endoscopic management of urologic disease with the holmium laser.
Curr Opin Urol.
2000;
10 (3)
233-237
- 27
Grasso M, Chalik Y.
Principles and applications of laser lithotripsy: experience with the holmium laser
lithotrite.
J Clin Laser Med Surg.
1998;
16 (1)
3-7
- 28
Sofer M, Watterson J D, Wollin T A, Nott L, Razvi H, Denstedt J D.
Holmium:YAG laser lithotripsy for upper urinary tract calculi in 598 patients.
J Urol.
2002;
167 (1)
31-34
- 29
Teichman J M, Vassar G J, Glickman R D.
Holmium:yttrium-aluminum-garnet lithotripsy efficiency varies with stone composition.
Urology.
1998;
52 (3)
392-397
- 30
Teichman J M, Rao R D, Rogenes V J, Harris J M.
Ureteroscopic management of ureteral calculi: electrohydraulic versus holmium:YAG
lithotripsy.
J Urol.
1997;
158 (4)
1357-1361
- 31
Michel M S, Knoll T, Ptaschnyk T, Kohrmann K U, Alken P.
Flexible ureterorenoscopy for the treatment of lower pole calyx stones: influence
of different lithotripsy probes and stone extraction tools on scope deflection and
irrigation flow.
Eur Urol.
2002;
41 (3)
312-316
- 32
Cybulski P A, Joo H, Honey R J.
Ureteroscopy: anesthetic considerations.
Urol Clin North Am.
2004;
31 (1)
43-47
- 33
Jeong H, Kwak C, Lee S E.
Ureteric stenting after ureteroscopy for ureteric stones: a prospective randomized
study assessing symptoms and complications.
BJU Int.
2004;
93 (7)
1032-1034
- 34
Srivastava A, Gupta R, Kumar A, Kapoor R, Mandhani A.
Routine stenting after ureteroscopy for distal ureteral calculi is unnecessary: results
of a randomized controlled trial.
J Endourol.
2003;
17 (10)
871-874
- 35
Lifshitz D A, Lingeman J E.
Ureteroscopy as a first-line intervention for ureteral calculi in pregnancy.
J Endourol.
2002;
16 (1)
19-22
- 36
Dogan H S, Tekgul S, Akdogan B, Keskin M S, Sahin A.
Use of the holmium:YAG laser for ureterolithotripsy in children.
BJU Int.
2004;
94 (1)
131-133
- 37
Satar N, Zeren S, Bayazit Y, Aridogan I A, Soyupak B, Tansug Z.
Rigid ureteroscopy for the treatment of ureteral calculi in children.
J Urol.
2004;
172 (1)
298-300
- 38
Andreoni C, Afane J, Olweny E, Clayman R V.
Flexible ureteroscopic lithotripsy: first-line therapy for proximal ureteral and renal
calculi in the morbidly obese and superobese patient.
J Endourol.
2001;
15 (5)
493-498
- 39
Albala D M, Assimos D G, Clayman R V, Denstedt J D, Grasso M, Gutierrez-Aceves J.
et al .
Lower pole I: a prospective randomized trial of extracorporeal shock wave lithotripsy
and percutaneous nephrostolithotomy for lower pole nephrolithiasis-initial results.
J Urol.
2001;
166 (6)
2072-2080
- 40
Lingeman J E, Siegel Y I, Steele B, Nyhuis A W, Woods J R.
Management of lower pole nephrolithiasis: a critical analysis.
J Urol.
1994;
151 (3)
663-667
- 41
Kim S C, Kuo R L, Lingeman J E.
Percutaneous nephrolithotomy: an update.
Curr Opin Urol.
2003;
13 (3)
235-241
- 42
Lahme S, Bichler K H, Strohmaier W L, Gotz T.
Minimally invasive PCNL in patients with renal pelvic and calyceal stones.
Eur Urol.
2001;
40 (6)
619-624
- 43
Desai M R, Kukreja R A, Desai M M, Mhaskar S S, Wani K A, Patel S H. et al .
A prospective randomized comparison of type of nephrostomy drainage following percutaneous
nephrostolithotomy: large bore versus small bore versus tubeless.
J Urol.
2004;
172 (2)
565-577
- 44
Raj G V, Auge B K, Weizer A Z, Denstedt J D, Watterson J D, Beiko D T. et al .
Percutaneous management of calculi within horseshoe kidneys.
J Urol.
2003;
170 (1)
48-51
- 45
Francesca F, Felipetto R, Mosca F, Boggi U, Rizzo G, Puccini R.
Percutaneous nephrolithotomy of transplanted kidney.
J Endourol.
2002;
16 (4)
225-227
- 46
Martin X, Murat F J, Feitosa L C, Rouviere O, Lyonnet D, Gelet A. et al .
Severe bleeding after nephrolithotomy: results of hyperselective embolization.
Eur Urol.
2000;
37 (2)
136-139
- 47
Knoll T, Michel M S, Kohrmann K U, Alken P.
Urologic interventional therapy of kidney calculi (II)-Endoscopic methods: ureterorenoscopy
and percutaneous nephrolitholapaxy.
Ther Umsch.
2003;
60 (2)
103-107
- 48
Knoll T, Heger K, Haecker A, Osman M, Alken P, Kohrmann K U. et al .
Percutaneous nephrolithotomy: Experience from 348 procedures.
Eur Urol.
2004;
3
42
- 49
Zegel H G, Pollack H M, Banner M C, Goldberg B B, Arger P H, Mulhern C. et al .
Percutaneous nephrostomy: comparison of sonographic and fluoroscopic guidance.
AJR Am J Roentgenol.
1981;
137 (5)
925-927
- 50
Skrepetis K, Doumas K, Siafakas I, Lykourinas M.
Laparoscopic versus open ureterolithotomy. A comparative study.
Eur Urol..
2001;
40 (1)
32-36
- 51
Keeley F X, Gialas I, Pillai M, Chrisofos M, Tolley D A.
Laparoscopic ureterolithotomy: the Edinburgh experience.
BJU Int.
1999;
84 (7)
765-769
- 52
Segura J W, Preminger G M, Assimos D G, Dretler S P, Kahn R I, Lingeman J E. et al
.
Nephrolithiasis Clinical Guidelines Panel summary report on the management of staghorn
calculi. The American Urological Association Nephrolithiasis Clinical Guidelines Panel.
J Urol.
1994;
151 (6)
1648-1651
- 53
Murray M J, Chandhoke P S, Berman C J, Sankey N E.
Outcome of extracorporeal shockwave lithotripsy monotherapy for large renal calculi:
effect of stone and collecting system surface areas and cost-effectiveness of treatment.
J Endourol.
1995;
9 (1)
9-13
- 54
Zhong P, Preminger G M.
Mechanisms of differing stone fragility in extracorporeal shockwave lithotripsy.
J Endourol.
1994;
8 (4)
263-268
- 55
Gupta N P, Singh D V, Hemal A K, Mandal S.
Infundibulopelvic anatomy and clearance of inferior caliceal calculi with shock wave
lithotripsy.
J Urol.
2000;
163 (1)
24-27
- 56
Keeley Jr F X, Moussa S A, Smith G, Tolley D A.
Clearance of lower-pole stones following shock wave lithotripsy: effect of the infundibulopelvic
angle.
Eur Urol.
1999;
36 (5)
371-375
- 57
Elbahnasy A M, Clayman R V, Shalhav A L, Hoenig D M, Chandhoke P, Lingeman J E. et
al .
Lower-pole caliceal stone clearance after shockwave lithotripsy, percutaneous nephrolithotomy,
and flexible ureteroscopy: impact of radiographic spatial anatomy.
J Endourol.
1998;
12 (2)
113-119
- 58
Knoll T, Musial A, Trojan L, Ptashnyk T, Michel M S, Alken P. et al .
Measurement of renal anatomy for prediction of lower-pole caliceal stone clearance:
reproducibility of different parameters.
J Endourol.
2003;
17 (7)
447-451
- 59
Madbouly K, Sheir K Z, Elsobky E.
Impact of lower pole renal anatomy on stone clearance after shock wave lithotripsy:
fact or fiction?.
J Urol.
2001;
165 (5)
1415-1418
- 60
Hollenbeck B K, Schuster T G, Faerber G J, Wolf J S.
Flexible ureteroscopy in conjunction with in situ lithotripsy for lower pole calculi.
Urology.
2001;
58 (6)
859-863
- 61
Pace K T, Weir M J, Tariq N, Honey R J.
Low success rate of repeat shock wave lithotripsy for ureteral stones after failed
initial treatment.
J Urol.
2000;
164 (6)
1905-1907
- 62
Wu C F, Shee J J, Lin W Y, Lin C L, Chen C S.
Comparison between extracorporeal shock wave lithotripsy and semirigid ureterorenoscope
with holmium:YAG laser lithotripsy for treating large proximal ureteral stones.
J Urol.
2004;
172 (5 Pt 1)
1899-1902
- 63
Peschel R, Janetschek G, Bartsch G.
Extracorporeal shock wave lithotripsy versus ureteroscopy for distal ureteral calculi:
a prospective randomized study.
J Urol.
1999;
162 (6)
1909-1912
- 64
Pearle M S, Nadler R, Bercowsky E, Chen C, Dunn M, Figenshau R S. et al .
Prospective randomized trial comparing shock wave lithotripsy and ureteroscopy for
management of distal ureteral calculi.
J Urol.
2001;
166 (4)
1255-1260
- 65
Buchholz N P, Meier-Padel S, Rutishauser G.
Minor residual fragments after extracorporeal shockwave lithotripsy: spontaneous clearance
or risk factor for recurrent stone formation?.
J Endourol.
1997;
11 (4)
227-232
- 66
Strohmaier W L.
Socioeconomic aspects of urinary calculi and metaphylaxis of urinary calculi.
Urologe A.
2000;
39 (2)
166-170
- 67
Hesse A, Brandle E, Wilbert D, Kohrmann K U, Alken P.
Study on the prevalence and incidence of urolithiasis in Germany comparing the years
1979 vs. 2000.
Eur Urol.
2003;
44 (6)
709-713
- 68
Caramia G, Di Gregorio L, Tarantino M L, Galuffo A, Iacolino R, Caramia M.
Uric acid, phosphate and oxalate stones: treatment and prophylaxis.
Urol Int..
2004;
72 Suppl 1
24-28
- 69
Chandhoke P S.
When is medical prophylaxis cost-effective for recurrent calcium stones?.
J Urol.
2002;
168 (3)
937-940
- 70
Hesse A, Siener R, Heynck H, Jahnen A.
The influence of dietary factors on the risk of urinary stone formation.
Scanning Microsc.
1993;
7 (3)
1119-1127
- 71
Klocke K, Hesse A, Vahlensieck W, Schneeberger W.
Prevention of recurrent stone formation: long time results under treatment based on
an extended metabolic investigation.
Urol Res.
1992;
20 (1)
94-95
- 72
Lotan Y, Cadeddu J A, Roerhborn C G, Pak C Y, Pearle M S.
Cost-effectiveness of medical management strategies for nephrolithiasis.
J Urol.
2004;
172 (6 Pt 1)
2275-2281
- 73
Heimbach D, Jacobs D, Muller S C, Hesse A.
Influence of alkaline solutions on chemolitholysis and lithotripsy of uric acid stones.
An in vitro study.
Eur Urol.
2000;
38 (5)
621-626
Dr. Thomas Knoll
Urologische Universitätsklinik · Klinikum Mannheim
Theodor-Kutzer-Ufer 1 - 3
68135 Mannheim
Phone: 0621/383-3349
Fax: 0621/383-734080
Email: t.knoll@uro.ma.uni-heidelberg.de