Radiofrequency Ablation and Radiotherapy: Complementing Treatments for Solid Tumors

ABSTRACT

This article outlines the complimentary role of radiofrequency ablation used in conjunction with radiotherapy. It defines the theory behind the treatment as well as specific clinical applications for the combination of this technique. It outlines the practical aspects of the combination therapy including the timing of the radiofrequency ablation versus radiotherapy, the fractionation of the doses, and the radiation doses.

KEYWORDS

Radiotherapy - radiofrequency ablation - tumors

REFERENCES

• 1 Goldberg S N, Dupuy D E. Image-guided radiofrequency tumor ablation: challenges and opportunities, part I.  J Vasc Interv Radiol . 2001;  12 1021-1032
• 2 Dupuy D E, Goldberg S N. Image-guided radiofrequency tumor ablation: challenges and opportunities, part II.  J Vasc Interv Radiol . 2001;  12 1135-1148
• 3 Dupuy D E, Zagoria R J, Akerley W, Mayo-Smith W W, Kavanaugh P V, Safran H. Percutaneous radiofrequency ablation of malignancies in the lung.  AJR Am J Roentgenol . 2000;  174 57-59
• 4 Dupuy D E, Monchik J M, Decrea C, Pisharodi L. Radiofrequency ablation of regional recurrence from well-differentiated thyroid malignancy.  Surgery . 2001;  130 971-977
• 5 Dupuy D E, Mayo-Smith W W, Abbott G, DiPetrillo T. Clinical applications of radiofrequency tumor ablation in the thorax.  Radiographics . 2002;  Spec No S259-269
• 6 Gervais D A, McGovern F J, Wood B J, Goldberg S N, McDougal W S, Mueller P R. Radiofrequency ablation of renal cell carcinoma: early clinical experience.  Radiology . 2000;  217 665-672
• 7 Nishida T, Inoue K, Kawata Y. et al . Percutaneous radiofrequency ablation of lung neoplasms: a minimally invasive strategy for inoperable patients.  J Am Coll Surg . 2002;  196 426-430
• 8 Schaefer O, Lohrmann C, Langer M. CT-guided radiofrequency ablation of a bronchogenic carcinoma.  Br J Radiol . 2003;  76(904) 268-270
• 9 Rohde D, Albers C, Mahnken A, Tacke J. Regional thermoablation of local or metastatic renal cell carcinoma.  Oncol Rep . 2003;  10(3) 753-757
• 10 Wood B J, Ramkaransingh J R, Fojo T, Walther M M, Libutti S K. Percutaneous tumor ablation with radiofrequency.  Cancer . 2002;  15(94) 443-451
• 11 Mirza A N, Fornage B D, Sneige N. et al . Radiofrequency ablation of solid tumors.  Cancer J . 2001;  7(2) 95-102
• 12 Bui Q T, Dupuy D E. Percutaneous CT-guided radiofrequency ablation of an adenoid cystic carcinoma of the head and neck.  AJR Am J Roentgenol . 2002;  179(5) 1333-1335
• 13 Friedman M A, Altemus R, Wood B. Radiofrequency ablation in a previously irradiated liver.  J Vasc Interv Radiol . 2003;  14 1345-1348
• 14 Rubin P, Johnston C J, Williams J P, Finkelstein J N. A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis.  Int J Radiat Oncol Biol Physiol . 1995;  33(1) 99-109
• 15 Hall E J. Radiobiology for the Radiologist, 5th ed. Baltimore, MD: Lippincott Williams & Wilkins; 2000 . 
• 16 Schmidt-Ullrich R K. Molecular targets in radiation oncology.  Oncogene . 2003;  22(37) 5730-5733
• 17 Dupuy D E, Chauhan B, Ready N, DiPetrillo T, Gaissert H, Fenton M A. Radiofrequency ablation followed by conventional radiotherapy for inoperable stage I non-small cell lung cancer.  American Society of Clinical Oncology Proceedings . 2003;  22 2632
• 18 Jain S K, Dupuy D E, Cardarelli G A, Zheng Z, DiPetrillo T A. Percutaneous radiofrequency ablation of lung malignancies: combined treatment with brachytherapy.  AJR Am J Roentgenol . 2003;  181 711-715