Abstract
Ginsenosides, the main effective components of the root of Panax ginseng, have been reported to modulate morphine action. In the present study, ginsenosides
Rd, Rb2, Rg1 and Re were divided into two groups according to their effects in mice
on morphine-induced hyperactivity and conditioned place preference (CPP). Ginsenosides
Rd, Rb2, Rg1 had no effect on morphine-induced hyperactivity, but antagonized morphine-induced
CPP. On the contrary, ginsenoside Re increased morphine-induced hyperactivity whereas
it showed no effect on morphine-induced CPP. Furthermore, Re antagonized the inhibitory
effect of the mixture involving Rd, Rb2 and Rg1 on the morphine action. These results
suggest that ginsenosides with different structures have antagonizing properties in
the regulation of morphine-induced reinforcement.
Abbreviations
CPP:conditioned place preference
NS:saline
Mor :morphine
G1111:ginsenosides Rd, Rb2, Rg1 and Re mixture at ratio of 1 : 1:1 : 1
G1112:ginsenosides Rd, Rb2, Rg1 and Re mixture at ratio of 1 : 1:1 : 2
L :low dose of ginsenosides, 0.5 × 10 - 5 mol/kg
H:high dose of ginsenosides, 1 × 10 - 5 mol/kg
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Dr. C. F. Wu
Department of Pharmacology
Shenyang Pharmaceutical University
Shenyang 110016
P. R. China
Phone: +86-24-2384-3567
Fax: +86-24-2384-3567
Email: wucf@syphu.edu.cn; wuchunf@21cn.com