Planta Med 2004; 70(7): 688-690
DOI: 10.1055/s-2004-827197
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Roles of Ginsenosides on Morphine-Induced Hyperactivity and Rewarding Effect in Mice

Ming Guo1 , 3 , Jin-Hui Wang2 , Jing-Yu Yang1 , Dan Zhu1 , Nan-Jie Xu3 , Gang Pei3 , Chun-Fu Wu1 , Xian Li2
  • 1Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, P.R. China
  • 2Laboratory of Chemistry for Natural Products, Shenyang Pharmaceutical University, Shenyang, P.R. China
  • 3Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Shanghai, P.R. China
This study was supported by the National Natural Science foundation, P.R. China (No. 30 171 138)
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Publikationsverlauf

Received: January 9, 2004

Accepted: March 20, 2004

Publikationsdatum:
15. Juli 2004 (online)

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Abstract

Ginsenosides, the main effective components of the root of Panax ginseng, have been reported to modulate morphine action. In the present study, ginsenosides Rd, Rb2, Rg1 and Re were divided into two groups according to their effects in mice on morphine-induced hyperactivity and conditioned place preference (CPP). Ginsenosides Rd, Rb2, Rg1 had no effect on morphine-induced hyperactivity, but antagonized morphine-induced CPP. On the contrary, ginsenoside Re increased morphine-induced hyperactivity whereas it showed no effect on morphine-induced CPP. Furthermore, Re antagonized the inhibitory effect of the mixture involving Rd, Rb2 and Rg1 on the morphine action. These results suggest that ginsenosides with different structures have antagonizing properties in the regulation of morphine-induced reinforcement.

Abbreviations

CPP:conditioned place preference

NS:saline

Mor :morphine

G1111:ginsenosides Rd, Rb2, Rg1 and Re mixture at ratio of 1 : 1:1 : 1

G1112:ginsenosides Rd, Rb2, Rg1 and Re mixture at ratio of 1 : 1:1 : 2

L :low dose of ginsenosides, 0.5 × 10 - 5 mol/kg

H:high dose of ginsenosides, 1 × 10 - 5 mol/kg