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DOI: 10.1055/s-2004-827196
Antimicrobial Activities of Hydrophobic 2-Arylbenzofurans and an Isoflavone against Vancomycin-Resistant Enterococci and Methicillin-Resistant Staphylococcus aureus
Publication History
Received: December 10, 2003
Accepted: April 24, 2004
Publication Date:
15 July 2004 (online)
Abstract
Eight 2-arylbenzofurans and an isoflavone isolated from medicinal plants were tested for their antimicrobial activities against vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). Among these compounds, six hydrophobic 2-arylbenzofurans (log P = 4.4 - 8.7) exhibited considerable antibacterial activity against five VRE strains (VanA-, VanB-, and VanC-phenotypes) (MICs = 3.13 - 6.25 μg/mL). Five compounds also showed antibacterial activity against ten MRSA strains (MIC80 = 3.13 μg/mL).
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Dr. Toshio Fukai
Department of Biophysical Chemistry
School of Pharmaceutical Sciences
Toho University
2-2-1 Miyama
Funabashi
Chiba 274-8510
Japan
Fax: +81-47-476-6195
Email: fukai@phar.toho-u.ac.jp