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Planta Med 2004; 70(7): 678-679
DOI: 10.1055/s-2004-827193
DOI: 10.1055/s-2004-827193
Letter
© Georg Thieme Verlag KG Stuttgart · New York
Guineensine, an Acyl-CoA: Cholesterol Acyltransferase Inhibitor, from the Fruits of Piper longum
This research was supported by a grant from Plant Diversity Research Center of 21st Century Frontier Research Program funded by Ministry of Science and Technology of Korean government, and by a grant of KRIBB Research Initiative Program.Further Information
Publication History
Received: January 20, 2004
Accepted: February 22, 2004
Publication Date:
15 July 2004 (online)
Abstract
Bioactivity-guided fractionations for ACAT inhibitor led to the isolation of guineensine from the CHCl3 extract of Piper longum. Its structure was identified by spectroscopic means (IR, UV, MS and NMR). Guineensine inhibited ACAT activity in a dose-dependent manner with an IC50 value of 3.12 µM.
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Dr. Young Kook Kim
Laboratory of Lipid Metabolism
Korea Research Institute of Bioscience and Biotechnology
52 Oun-dong
Yusong-gu
Taejon 305 - 333
Korea
Phone: +82-42-860-4556
Fax: +82-42-861-2675
Email: kimyk@kribb.re.kr