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DOI: 10.1055/s-2004-827179
© Georg Thieme Verlag KG Stuttgart · New York
Neurotrophic Effects of Talaumidin, a Neolignan from Aristolochia arcuata, in Primary Cultured Rat Cortical Neurons
Publication History
Received: December 10, 2003
Accepted: February 15, 2004
Publication Date:
15 July 2004 (online)
Abstract
Talaumidin, a tetrahydrofuran neolignan isolated from the root of Aristolochia arcuata, was shown to be an intriguing small molecule with neurotrophic activity in the primary culture of rat cortical neurons. Talaumidin can promote both dendrite-like and axon-like process outgrowth of cultured rat cortical neurons at the concentration range of 1 - 30 μM. Additionally, in the trophic withdrawal model, it can protect cell death caused by the deprivation of serum at the concentration range of 3 - 30 μM. These data suggest the potential of talaumidin to serve as a promising lead compound for treatment of neurodegenerative diseases.
Abbreviations
bFGF:human recombinant basic fibroblast growth factor
MTT:thiazolyl blue tetrazolium bromide
MAP2:microtubule-associated protein 2
tau:tau protein, one of microtubule-associated proteins
DMEM:Dulbecco’s modified Eagle medium
IgG:immunoglobulin G
Key words
Talaumidin - neolignan - Aristolochia arcuata - Aristolochiaceae - rat cortical neurons - neurotrophic effect
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Prof. Yoshiyasu Fukuyama
Institute of Pharmacognosy
Faculty of Pharmaceutical Sciences
Tokushima Bunri University
180 Yamashiro-cho
Tokushima 770-8514
Japan
Fax: +81-88-622-9611
Email: fukuyama@ph.bunri-u.ac.jp