Eicosanoid Regulation of Angiogenesis in Tumors

Daotai Nie; Kenneth V. Honn

doi:10.1055/s-2004-822976

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2004; 30(1): 119-125
DOI: 10.1055/s-2004-822976

Eicosanoid Regulation of Angiogenesis in Tumors

Daotai Nie¹ , Kenneth V. Honn²

¹Departments of Radiation Oncology and Pathology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan
²Professor, Departments of Radiation Oncology and Pathology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan

Abstract

Tumor angiogenesis, the formation of new capillary blood vessels in tumors from pre-existing vasculature, is required for tumor growth and progression. Eicosanoids, the bioactive lipids derived from arachidonic acid, possess potent and diverse biological activities. In response to stimuli, arachidonic acid is mobilized from phospholipid pools and metabolized by cyclooxygenases (COX), lipoxygenases (LOX), and p450 epoxygenases (EOX) to form a variety of eicosanoids. The involvement of eicosanoids in tumor angiogenesis and progression is implicated by the observations that nonsteroidal anti-inflammation drugs (NSAIDs) reduce tumor growth and angiogenesis. Subsequently, it is found that the levels of COX-2 and/or 12-LOX are frequently increased in various cancers. Further studies using molecular and pharmacological approaches have found that COX-2 and 12-LOX, when overexpressed in carcinoma cells, enhance their angiogenic potential and stimulate tumor growth. In this article, we discuss how COX and LOX in cancer cells modulate tumor angiogenesis and present the possibility of using NSAIDs and LOX inhibitors as antiangiogenesis agents.

KEYWORDS

Angiogenesis - cancer - eicosanoids - arachidonic acid - nonsteroidal anti-inflammatory drugs

Full Text

References

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Kenneth HonnPh.D.

Departments of Radiation Oncology and Pathology, Wayne State University School of Medicine and Karmanos Cancer Institute

431 Chemistry Bldg., Detroit, MI 48202

Email: k.v.honn@wayne.edu