Pneumologie 2004; 58(8): 570-602
DOI: 10.1055/s-2004-818356
Leitlinie
© Georg Thieme Verlag Stuttgart · New York

Leitlinie der Deutschen Gesellschaft für Pneumologie zur Diagnostik und Therapie von Patienten mit akutem und chronischem Husten

Guideline of the German Respiratory Society for Diagnosis and Treatment of Patients Suffering from Acute or Chronic CoughP.  Kardos1 , U.  Cegla2 , A.  Gillissen3 , D.  Kirsten4 , H.  Mitfessel5 , H.  Morr6 , G.  Schultze-Werninghaus7 , H.  Sitter8 , C.  Vogelmeier9 , T.  Voshaar10 , H.  Worth11 , V.  Eckardt12 , L.  Klimek13
  • 1Gemeinschaftspraxis und Pneumologisches-Allergologisches Zentrum Maingau Krankenhaus Frankfurt am Main. Dres. T. Gebhardt, A. Iwantscheff und P. Kardos
  • 2Zentrum für Pneumologie, Allergologie und Schlafmedizin am Herz Jesu Krankenhaus Dernbach
  • 3Robert-Koch-Klinik, Leipzig
  • 4Krankenhaus Großhansdorf, Zentrum für Pneumologie und Thoraxchirurgie
  • 5Gemeinschaftspraxis für Pneumologie, Allergologie, Umweltmedizin und Schlafmedizin am Krankenhaus Wermelskirchen, Remscheid
  • 6Pneumologische Klinik Waldhof Elgershausen, Greifenstein
  • 7Berufsgenossenschaftliche Kliniken Bergmannsheil Klinikum der Ruhr-Universität Bochum
  • 8Institut für Theoretische Chirurgie, Philipps-Universität, Marburg
  • 9Klinik für Innere Medizin - Schwerpunkt Pneumologie Philipps Universität, Marburg
  • 10Medizinische Klinik III Schwerpunkt Pneumologie, Allergologie, Zentrum für Schlafmedizin und Heimbeatmung, Krankenhaus Bethanien, Moers
  • 11Medizinische Klinik I, Klinikum Fürth
  • 12Deutsche Klinik für Diagnostik Gastroenterologie II, Wiesbaden
  • 13Zentrum für Rhinologie und Allergologie, Wiesbaden
Further Information

Publication History

Publication Date:
04 August 2004 (online)

Inhalt Seite 1 Struktur der Leitlinie 571 Präambel 571 1.1 Schema der Leitlinienentwicklung 571 1.2 Klinische Evidenz der Leitlinie 572 1.3 Klinische Algorithmen 572 1.4 Teilnahme von Industrievertretern 573 1.5 Veröffentlichung, Verbreitung und Aktualisierung der Leitlinie 573 1.6 Sponsoring 573 2 Epidemiologie 573 3 Anmerkungen zur Physiologie des Hustens 573 3.1 Der Hustenreflex 573 3.2 Husten und Bronchospasmus 574 3.3 Produktiver und nicht-produktiver Husten 574 3.4 Eigenschaften des Auswurfs 574 4 Ursachen und Klassifizierung des Hustens 575 5 Akuter Husten: die wichtigsten Krankheitsbilder 576 5.1 Infektiöse Erkrankungen der oberen Atemwege 576 5.2 Allergische Erkrankungen der oberen Atemwege 576 5.3 Asthma 576 5.4 Aspiration 576 5.5 Akute inhalative Intoxikationen (Unfälle am Arbeitsplatz, Rauchgasvergiftungen) 576 5.6 Postinfektiöser Husten 576 5.7 Pneumonie 577 5.8 Pleuritis 577 5.9 Lungenembolie 577 5.10 Pneumothorax 577 5.11 Akute Linksherzinsuffizienz 577 5.12 AV Block II. und III. Grades 577 6 Chronischer Husten: die wichtigsten Krankheitsbilder 577 6.1 Asthma 577 6.2 COPD 577 6.3 Bronchialtumoren 578 6.4 Aspiration 578 6.5 Diffuse Lungenparenchymerkrankungen - Systemerkrankungen mit Lungenbeteiligung 579 6.6 Seltene isolierte Erkrankungen des Tracheobronchialsystems 579 6.6.1 Tracheo-Bronchomegalie (M. Mounier-Kuhn) 579 6.6.2 Tracheobronchiale Amyloidose 579 6.6.3 Rezidivierende Polychondritis 579 6.6.4 Tracheobronchopathia osteoplastica 580 6.6.5 Juvenile laryngotracheale Amyloidose 580 6.7 RADS (Reactive airways dysfunction syndrome) 580 6.8 VCD (Vocal cord dysfunction) 580 6.9 Tuberkulose 580 6.10 Keuchhusten 581 6.11 Linksherzinsuffizienz 581 6.12 Endokarditis 581 6.13 Husten als Nebenwirkung einer medikamentösen kardialen Therapie 581 7 Chronisch persistierender Husten (CPH) 581 7.1 Erkrankungen im Bereich von Nase und Nebenhöhlen 582 7.2 Erkrankungen im Bereich von Pharynx und Larynx 582 7.3 Husten als Asthmaäquivalent 582 7.4 Gastroösophageale Refluxkrankheit 583 7.5 Chronische, nicht obstruktive Bronchitis 584 7.6 Bronchiektasen 584 7.7 Chronischer Husten unklarer Ursache 585 7.8 Psychogener Husten 585 7.9 Husten als Nebenwirkung von Medikamenten 585 7.10 Bronchomalazie 586 7.11 Eosinophile Bronchitis 586 7.12 Zystische Fibrose 586 8 Diagnostik 586 8.1 Akuter Husten 587 8.2 Chronischer Husten 589 8.3 Ambulante und stationäre Diagnostik 590 8.4 Nebenwirkungen, Komplikationen und Kosten der Diagnostik 590 8.5 Zusammenfassung der wichtigsten Empfehlungen zur Diagnostik 590 9 Häufige Fehler bei der Stufendiagnostik des Hustens 590 10 Therapie 591 10.1.1 Physiotherapie bei produktivem Husten 591 10.1.2 Physiotherapie bei unproduktivem Husten 592 10.1.3 Atemphysiotherapie unter Zuhilfenahme von Geräten 592 10.2 Hustentherapeutika mit Wirkung am Hustenrezeptor 592 10.2.1 Expektorantien 593 10.2.2 Medikamente, die die Schleimproduktion verringern 593 10.2.3 Medikamente zur Steigerung der mukoziliären Clearance 593 10.2.4. Medikamente zur Reduktion der Reizung der Hustenrezeptoren 594 10.2.5 Schleimhautabschwellende Substanzen 594 10.2.6 Antibiotika 594 10.2.7 Entzündungshemmende Substanzen 595 10.3 Hustentherapeutika mit Wirkung am Hustenreflexbogen: Lokalanästhetika 595 10.4 Zentral wirksame Antitussiva 595 10.5 Hustentherapeutika mit Wirkung am Effektororgan 595 11 Komplikationen des Hustens 595 Anhang 1 Teilnehmerliste der Konsensustreffen 596 Anhang 2 Ableitung von Qualitätsindikatoren aus der Leitlinie Husten 596 Anhang 3 Zusammenfassung der Leitlinie 597

Literatur

  • 1 Gesellschaft für Pädiatrische Pneumologie. Leitlinie der Gesellschaft für Pädiatrische Pneumologie .Husten. Hofmann D http://www. awmf-online.de/ 1998
  • 2 Dt. Ges. f. Hals-Nasen-Ohren-Heilkunde KuH-C . Leitlinie Reizhusten/Räusperzwang Kinder (Klinischer Algorithmus).  HNO-Mitteilungen. 1997;  45 (3) 7S
  • 3 Irwin R S, Boulet L P, Cloutier M M. et al . Managing cough as a defense mechanism and as a symptom. A consensus panel report of the American College of Chest Physicians.  Chest. 1998;  114 (2) 133S-181
  • 4 Society for Medical Decision Making . Committee on standardization of clinical algorithms Proposals for clinical algorithm standards.  Med Decis Making. 1992;  12 49-154
  • 5 Schappert S M. National ambulatory medical care survey: 1991.  Summary. 1993;  230 1-20
  • 6 Anon Y. Office Visits to Internists: The National Ambulatory Medical Care Survey 1975.  Vital and Health Statistics Series 13.. 1978;  36 29
  • 7 Roche N, Huchon G. Du symptome au diagnostic: toux.  Pneumologie. 1997;  6 - 090 (A-15) 6
  • 8 Kirsten D. Die Top-ten der Pneumologie. Hamburg: Kongress der Deutschen Gesellschaft für Pneumologie 2000
  • 9 Kanzow G, Kirsten D, Magnussen H. Stufendiagnostik in der Pneumologie am Beispiel der Leitsymptome: Husten, Hämoptysen, Dyspnoe.  Internist. 1996;  37 132-139
  • 10 Widdicombe J G. Neurophysiology of the cough reflex.  Eur Respir J. 1995;  8 (7) 1193-1202
  • 11 Braman S S, Corrao W M. Cough: differential diagnosis and treatment.  Clin Chest Med. 1987;  8 (2) 177-188
  • 12 Kardos P. Chronisch persistierender Husten (CHP).  Pneumologie. 1995;  49 (1) 2-13
  • 13 Irwin R. Cough. In: Irwin R, Curley F, Grossmann R. Symptoms of the Respiratory Tract. USA: Futura Publishing Company Inc., Armonk, N.Y 1997 (1): 1-54
  • 14 Kohler D, Vastag E. Bronchiale Clearance.  Pneumologie. 1991;  45 (5) 314-332
  • 15 Salem H, Aviado D. Antitussive Drugs.  Am J Med Sci. 1964;  247 585-600
  • 16 Pomerantz M, Braman S. Cough Reflexes in Asthma.  Am Rev Respir Dis. 1992;  A12 89
  • 17 Sheppard D, Rizk N W, Boushey H A. et al . Mechanism of cough and bronchoconstriction induced by distilled water aerosol.  Am Rev Respir Dis. 1983;  127 (6) 691-694
  • 18 Lalloo U G, Barnes P J, Chung K F. Pathophysiology and clinical presentations of cough.  J Allergy Clin Immunol. 1996;  98 (5 Pt 2) S91-S96
  • 19 Chang A B, Gibson P G. Relationship between cough, cough receptor sensitivity and asthma in children.  Pulm Pharmacol Ther. 2002;  15 (3) 287-291
  • 20 Smyrnios N A, Irwin R S, Curley F J. Chronic Cough with a history of excessive sputum production. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy.  Chest. 1995;  108 (4) 991-997
  • 21 Corren J. The Impact of allergic rhinitis on bronchial asthma.  J Allergy Clin Immunol. 1998;  101 (2 PT 2) S352-S356
  • 22 Poe R H, Israel R H, Utell M J. et al . Chronic Cough: Bronchoscopy or pulmonary function testing?.  Am Rev Respir Dis. 1982;  126 (1) 160-162
  • 23 Poe R H, Harder R V, Israel R H. et al . Chronic Persistent Cough. Experience in Diagnosis and outcome using an anatomic diagnostic protocol.  Chest. 1989;  95 (4) 723-728
  • 24 Holinger L D, Sanders A D. Chronic Cough in infants and children: an update.  Laryngoscope. 1991;  101 (6 PT 1) 596-605
  • 25 Mello C J, Irwin R S, Curley F J. Predictive Values of the character, timing, and complications of chronic cough in diagnosing its cause.  Arch Intern Med. 1996;  156 (9) 997-1003
  • 26 Kardos P, Gebhardt T. Chronisch persistierender Husten (CPH) in der Praxis: Diagnostik und Therapie bei 329 Patienten in 2 Jahren.  Pneumologie. 1996;  50 (6) 437-441
  • 27 Palombini B C, Villanova C A, Araújo E. et al . A pathogenic triad in chronic cough: asthma, postnasal drip syndrome, and gastroesophageal reflux disease.  Chest. 1999;  116 (2) 279-284
  • 28 Irwin R S, Corrao W M, Pratter M R. Chronic Persistent Cough in the adult: the spectrum and frequency of causes and successful outcome of specific therapy.  Am Rev Respir Dis. 1981;  123 (4 PT 1) 413-417
  • 29 McGarvey L P, Heaney L G, Lawson J T. et al . Evaluation and outcome of patients with chronic non-productive cough using a comprehensive diagnostic protocol.  Thorax. 1998;  53 (9) 738-743
  • 30 Irwin R S, Madison J M. Review Articles Primary Care: The Diagnosis and Treatment of Cough.  The New England Journal of Medicine. 2000;  343 (23) 1715-1721
  • 31 Irwin R S, Madison J M. The Persistently Troublesome Cough.  American Journal of Respiratory and Critical Care Medicine. 2002;  165 (11) 1469-1474
  • 32 Macfarlane J T, Colville A, Guion A. et al . Prospective study of aetiology and outcome of adult lower-respiratory-tract infections in the community.  Lancet. 1993;  341 (8844) 511-514
  • 33 Arroll B, Kenealy T. Antibiotics for acute bronchitis.  BMJ. 2001;  322 (7292) 939-940
  • 34 Heikkinen T, Järvinen A. The common cold.  Lancet. 2003;  361 (9351) 51-59
  • 35 Interdisziplinäre Arbeitsgruppe „Allergische Rhinitis” der Sektion HNO Allergische Rhinokonjunktivitis . Leitlinie der Deutschen Gesellschaft für Allergologie und klinische Immunologie.  Allergo J. 2003;  12 (4) 182-194
  • 36 Wettengel R, Berdel D, Hofmann D. et al . Empfehlungen für Asthmatherapie bei Kindern und Erwachsenen.  Pneumologie. 1998;  52 (11) 591-601
  • 37 Barber C M, Curran A D, Fishwick D. et al . Impaired cough reflex in patients with recurrent pneumonia.  Thorax. 2003;  58 (7) 645-646
  • 38 Worth H, Adam D, Handrick W. et al . Prevention und Therapie von bronchialen Infektionen. Empfehlungen der Deutschen Atemwegsliga und der Deutschen Gesellschaft für Pneumologie.  Pneumologie. 1998;  52 (4) 232-237
  • 39 Stein P D, Willis P W, DeMets D L. History and physical examination in acute pulmonary embolism in patients without preexisting cardiac or pulmonary disease.  Am J Cardiol. 1981;  47 (2) 218-223
  • 40 Meissner E, Niedermeyer J, Worth H. et al . Diagnose der akuten Lungenembolie. Empfehlungen der Deutschen Gesellschaft für Pneumologie.  Pneumologie. 2000;  54 (12) 587-591
  • 41 Brunnee T, Graf K, Kastens B. et al . Bronchial hyperreactivity in patients with moderate pulmonary circulation overload.  Chest. 1993;  103 (5) 1477-1481
  • 42 Pison C, Malo J L, Rouleau J L. et al . Bronchial hyperresponsiveness to inhaled methacholine in subjects with chronic left heart failure at a time of exacerbation and after increasing diuretic therapy.  Chest. 1989;  96 (2) 230-235
  • 43 Lee D, Beldner S, Pollaro F. et al . Cough-induced heart block.  Pacing Clin Electrophysiol. 1999;  22 (8) 1270-1271
  • 44 Baron S B, Huang S K. Cough syncope presenting as Mobitz type II atrioventricular block - an electrophysiologic correlation.  Pacing Clin Electrophysiol. 1987;  10 (1 Pt 1) 65-69
  • 45 Saito D, Matsuno S, Matsushita K. et al . Cough syncope due to atrio-ventricular conduction block.  Jpn Heart J. 1982;  23 (6) 1015-1020
  • 46 Hart G, Oldershaw P J, Cull R E. et al . Syncope caused by cough-induced complete atrioventricular block.  Pacing Clin Electrophysiol. 1982;  5 (4) 564-566
  • 47 Mitton M. Paroxysmal atrioventricular block in a healthy patient receiving spinal anesthesia: a case report.  AANA J. 1993;  61 (6) 605-609
  • 48 Worth H, Buhl R, Cegla U. et al . Leitlinie der Deutschen Atemwegsliga und der Deutschen Gesellschaft für Pneumologie zur Diagnostik und Therapie von Patienten mit chronisch obstruktiver Lungenerkrankung (COPD).  Pneumologie. 2002;  56 (11) 704-738
  • 49 Lee J J, Lin R L, Chen C H. et al . Clinical manifestations of bronchogenic carcinoma.  J Formos Med Assoc. 1992;  91 (2) 146-151
  • 50 Hyde L, Hyde C I. Clinical manifestations of lung cancer.  Chest. 1974;  65 (3) 299-306
  • 51 Saito Y, Nagamoto N, Ota S. et al . Results of surgical treatment for roentgenographically occult bronchogenic squamous cell carcinoma.  J Thorac Cardiovasc Surg. 1992;  104 (2) 401-407
  • 52 Thomas M, Gatzemeier U, Goerg R. et al . Empfehlungen zur Diagnostik des Bronchialkarzinoms.  Pneumologie. 2000;  54 (8) 361-371
  • 53 Thomas M, Baumann M, Deppermann M. et al . Empfehlungen zur Therapie des Bronchialkarzinoms.  Pneumologie. 2002;  56 (2) 113-131
  • 54 Fontana G A, Lavorini F, Pistolesi M. Water aerosols and cough.  Pulm Pharmacol Ther. 2002;  15 (3) 205-211
  • 55 Ebihara S, Saito H, Kanda A. et al . Impaired Efficacy of Cough in Patients With Parkinson Disease.  Chest. 2003;  124 (3) 1009-1015
  • 56 Lalloo U G, Lim S, DuBois R. et al . Increased sensitivity of the cough reflex in progressive systemic sclerosis patients with interstitial lung disease.  Eur Respir J. 1998;  11 (3) 702-705
  • 57 Spira A, Grossman R, Balter M. Large airway disease associated with inflammatory bowel disease.  Chest. 1998;  113 (6) 1723-1726
  • 58 Lengyel C, Boros I, Varkonyi T. et al . (Amiodarone-induced pulmonary fibrosis).  Orv Hetil. 1996;  137 (32) 1759-1762
  • 59 Imokawa S, Colby T V, Leslie K O. et al . Methotrexate pneumonitis: review of the literature and histopathological findings in nine patients.  Eur Respir J. 2000;  15 (2) 373-381
  • 60 Strimlan C V, Rosenow E C, Divertie M B. et al . Pulmonary manifestations of Sjoegren's syndrome.  Chest. 1976;  70 (03) 354-361
  • 61 Cain H C, Noble P W, Matthay R A. Pulmonary manifestations of Sjoegren's syndrome.  Clin Chest Med. 1998;  19 (4) 687-99, viii
  • 62 Ukena D, Harnest U, Sakalauskas R. et al . Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma.  Eur Respir J. 1997;  10 (12) 2754-2460
  • 63 Larson T S, Hall S, Hepper N G. et al . Respiratory tract symptoms as a clue to giant cell arteritis.  Ann Intern Med. 1984;  101 (5) 594-597
  • 64 Olopade C O, Sekosan M, Schraufnagel D E. Giant Cell Arteritis Manifesting as chronic cough and fever of unknown origin.  Mayo Clin Proc. 1997;  72 (11) 1048-1050
  • 65 Breton J L, Ranfaing E, Depierre A. et al . (Bronchial involvement disclosing Wegener's granulomatosis).  Rev Mal Respir. 1986;  3 (3) 153-155
  • 66 Daum T E, Specks U, Colby T V. et al . Tracheobronchial involvement in Wegener's granulomatosis.  Am J Respir Crit Care Med. 1995;  151 (2 Pt 1) 522-526
  • 67 Camus P, Piard F, Ashcroft T. et al . The lung in inflammatory bowel disease.  Medicine (Baltimore). 1993;  72 (3) 151-183
  • 68 Bargon J, Rust M, Kardos P. et al . Salazosulfapyridine-induzierte eosinophile Pneumonie mit pulmonaler und kutaner epitheloidzelliger Granulomatose bei Sjögren syndrome.  Pneumologie. 1990;  44 (4) 744-750
  • 69 Shub C, Alexander B B. Persistent cough - the presenting feature in unsuspected sarcoidosis: a case report.  Mil Med. 1971;  136 (9) 757-758
  • 70 Baughman R P, Iannuzzi M C, Lower E E. et al . Use of fluticasone in acute symptomatic pulmonary sarcoidosis.  Sarcoidosis Vasc Diffuse Lung Dis. 2002;  19 (3) 198-204
  • 71 Usalan C, Emri S. Exertional dyspnoea and nonproductive cough in a 22-year-old man.  Postgrad Med J. 2000;  76 (892) 115-117
  • 72 Kirsten D. Deutsche Gesellschaft für Pneumologie: Empfehlungen für Diagnosis und Therapie der Sarkoidose.  Pneumologie. 1998;  52 (1) 26-30
  • 73 Fink J B. Metered-dose inhalers, dry powder inhalers, and transitions.  Respir Care. 2000;  45 (6) 623-635
  • 74 Rapti A, Drossos C, Tzavelas D. et al . Mounier-Kuhn syndrome (tracheobronchomegaly).  Monaldi Arch Chest Dis. 1995;  50 (3) 195-198
  • 75 Schwartz M, Rossoff L. Tracheobronchomegaly.  Chest. 1994;  106 (5) 1589-1590
  • 76 Kirchner J, Jacobi V, Kardos P. et al . CT findings in extensive tracheobronchial amyloidosis.  Eur Radiol. 1998;  8 (3) 352-354
  • 77 Molina J F, Espinoza L R. Relapsing polychondritis.  Baillieres Best Pract Res Clin Rheumatol. 2000;  14 (1) 97-109
  • 78 Leske V, Lazor R, Coetmeur D. et al . Tracheobronchopathia osteochondroplastica: a study of 41 patients.  Medicine (Baltimore). 2001;  80 (6) 378-390
  • 79 Sutor G C, Glaab T, Eschenbruch C. et al . Tracheobronchopathia osteochondroplastica: eine ungewöhnliche Ursache einer Retentionspneumonie.  Pneumologie. 2001;  55 (12) 563-567
  • 80 Sen R P, Walsh T E. Fiberoptic bronchoscopy for refractory cough.  Chest. 1991;  99 (1) 33-35
  • 81 Walther E K, Herberhold C. Die Behandlung der laryngotrachealen Papillomatose mit kombinierter Laserchirurgie und localer Administration von α-Interferon (Roferon).  Laryngorhinootologie. 1993;  72 (10) 485-491
  • 82 Guillou L, Sahli R, Chaubert P. et al . Squamous cell carcinoma of the lung in a nonsmoking, nonirradiated patient with juvenile laryngotracheal papillomatosis. Evidence of human papillomavirus-11 DNA in both carcinoma and papillomas.  Am J Surg Pathol. 1991;  15 (9) 891-898
  • 83 Sweriduk S T, DeLuca S A. Juvenile laryngotracheal papillomatosis.  Am Fam Physician. 1986;  33 (4) 155-156
  • 84 Schonhofer B, Voshaar T, Kohler D. Long-term lung sequelae following accidental chlorine gas exposure.  Respiration. 1996;  63 (3) 155-159
  • 85 Brooks S M, Weiss M A, Bernstein I L. Reactive airways dysfunction syndrome (RADS). Persistent asthma syndrome after high level irritant exposures.  Chest. 1985;  88 (3) 376-384
  • 86 Brooks S M, Hammad Y, Richards I. et al . The spectrum of irritant-induced asthma: sudden and not-so-sudden onset and the role of allergy.  Chest. 1998;  113 (1) 42-49
  • 87 Christopher K L, Wood R P, Eckert R C. et al . Vocal-cord dysfunction presenting as asthma.  N Engl J Med. 1983;  308 (26) 1566-1570
  • 88 Newman K B, Mason U G, Schmaling K B. Clinical features of vocal cord dysfunction.  Am J Respir Crit Care Med. 1995;  152 (4 Pt 1) 1382-1386
  • 89 Thomas P S, Geddes D M, Barnes P J. Pseudo-steroid resistant asthma.  Thorax. 1999;  54 (4) 352-356
  • 90 Kenn K, Schmitz M. Vocal cord dysfunction, eine wichtige Differenzialdaignose des schweren Asthma bronchiale.  Pneumologie. 1997;  51 (1) 14-18
  • 91 Ip M S, So S Y, Lam W K. et al . Endobronchial tuberculosis revisited.  Chest. 1986;  89 (5) 727-730
  • 92 Lee J H, Park S S, Lee D H. et al . Endobronchial tuberculosis. Clinical and bronchoscopic features in 121 cases (published erratum appears in Chest 1993; 103 (5): 1640).  Chest. 1992;  102 (4) 990-994
  • 93 Pierson D J, Lakshminarayan S, Petty T L. Endobronchial tuberculosis.  Chest. 1973;  64 (4) 537-539
  • 94 Schaberg T, Forssbohm M, Hauer B. et al . Richtlinien zur medikamentösen Behandlung der Tuberkulose im Erwachsenen- und Kindesalter.  Pneumologie. 2001;  55 (11) 494-511
  • 95 Wright S W, Edwards K M, Decker M D. et al . Pertussis infection in adults with persistent cough.  JAMA. 1995;  273 (13) 1044-1046
  • 96 Birkebaek N H, Kristiansen M, Seefeldt T. et al . Bordetella pertussis and chronic cough in adults.  Clin Infect Dis. 1999;  29 (5) 1239-1242
  • 97 Jackson L A, Cherry J D, Wang S P. et al . Frequency of serological evidence of Bordetella infections and mixed infections with other respiratory pathogens in university students with cough illnesses.  Clin Infect Dis. 2000;  31 (1) 3-6
  • 98 Vincent J M, Cherry J D, Nauschuetz W F. et al . Prolonged afebrile nonproductive cough illnesses in American soldiers in Korea: a serological search for causation.  Clin Infect Dis. 2000;  30 (3) 534-539
  • 99 Martin L, Gustaferro C. Chronic Cough Associated With Subacute Bacterial endocarditis.  Mayo Clin Proc. 1995;  70 (7) 662-664
  • 100 Irwin R S, Rosen M J, Braman S S. Cough. A comprehensive review.  Arch Intern Med. 1977;  137 (9) 1186-1191
  • 101 Irwin R S, Curley F J, French C L. Chronic Cough. The Spectrum And Frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy.  Am Rev Respir Dis. 1990;  141 (3) 640-647
  • 102 Holinger L D. Chronic Cough In Infants And Children.  Laryngoscope. 1986;  96 (3) 316-322
  • 103 Federspil P. Antibiotische Therapie von Infektionen im Bereich von Kopf und Hals. Deutsche Gesellschaft für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie.  Laryngorhinootologie. 2000;  79 (6) 366-377
  • 104 Dt. Ges. f. Hals-Nasen-Ohren-Heilkunde KuH-C . Leitlinie Reizhusten/Räusperzwang Erwachsene (Klinischer Algorithmus).  HNO-Mitteilungen. 1997;  47 (3) 6S
  • 105 Berg P, Wehrli R, Medici T C. Asthmahusten. Das monosymptomatische Bronchialasthma in Form von chronischem Husten.  Dtsch Med Wochenschr. 1986;  111 (45) 1730-1731
  • 106 Connell E J, Rojas A R, Sachs M I. Cough-type asthma: a review.  Ann Allergy. 1991;  66 (4) 278-282, 285
  • 107 Corrao W M, Braman S S, Irwin R S. Chronic Cough as the sole presenting manifestation of bronchial asthma.  N Engl J Med. 1979;  300 (12) 633-637
  • 108 Frans A, Eeckhaut J Van Den. Cough as the sole manifestation of airway hyperreactivity.  J Laryngol Otol. 1989;  103 (7) 680-682
  • 109 Johnson D, Osborn L M. Cough Variant Asthma: A review of the clinical literature.  J Asthma. 1991;  28 (2) 85-90
  • 110 Nowak D, Heinrich J, Jorres R. et al . Prevalence of respiratory symptoms, bronchial hyperresponsiveness and atopy among adults: west and east Germany.  Eur Respir J. 1996;  9 (12) 2541-2552
  • 111 Sears M R, Jones D T, Holdaway M D. et al . Prevalence of bronchial reactivity to inhaled methacholine in New Zealand children.  Thorax. 1986;  41 (4) 283-289
  • 112 Dicpinigaitis P. Zafirlukast in cough-variant asthma.  J Asthma. 2002;  39 291-297
  • 113 Fujimura M, Ogawa H, Nishizawa Y. et al . Comparison of atopic cough with cough variant asthma: is atopic cough a precursor of asthma?.  Thorax. 2003;  58 (1) 14-18
  • 114 Hollenz M, Stolte M, Labenz J. Prevalänz des gastro-ösophagealen Refluxes in der Allgemeinpraxis.  Dtsch Med Wochenschr. 2002;  127 (19) 1007-1012
  • 115 Peterson W. Improving the Management of GERD. Evidence-based therapeutic strategies. American Gastroenterological Association Consensus Development Panel. AGA Edition 2002
  • 116 Marchesani F, Cecarini L, Pela R. et al . Causes of chronic persistent cough in adult patients: the results of a systematic management protocol.  Monaldi Arch Chest Dis. 1998;  53 (5) 510-514
  • 117 Schnatz P F, Castell J A, Castell D O. Pulmonary symptoms associated with gastroesophageal reflux: use of ambulatory pH monitoring to diagnose and to direct therapy.  Am J Gastroenterol. 1996;  91 (9) 1715-1718
  • 118 Paterson W G, Murat B W. Combined ambulatory esophageal manometry and dual-probe pH-metry in evaluation of patients with chronic unexplained cough.  Dig Dis Sci. 1994;  39 (5) 1117-1125
  • 119 Ing A J, Ngu M C, Breslin A B. Chronic Persistent Cough And Gastro-oesophageal Reflux.  Thorax. 1991;  46 (7) 479-483
  • 120 Koufman J A. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury.  Laryngoscope. 1991;  101 (4 Pt 2 Suppl 53) 1-78
  • 121 Poe R H, Kallay M C. Chronic Cough and Gastroesophageal Reflux Disease: Experience With Specific Therapy for Diagnosis and Treatment.  Chest. 2003;  123 (3) 679-684
  • 122 Schmidt D, Jorres R A, Magnussen H. Citric acid-induced cough thresholds in normal subjects, patients with bronchial asthma, and smokers.  Eur J Med Res. 1997;  2 (9) 384-388
  • 123 Avidan B, Sonnenberg A, Schnell T G. et al . Temporal associations between coughing or wheezing and acid reflux in asthmatics.  Gut. 2001;  49 (6) 767-772
  • 124 Harding S M, Guzzo M R, Richter J E. 24-h esophageal pH-testing in asthmatics: respiratory symptom correlation with esophageal acid events.  Chest. 1999;  115 (3) 654-659
  • 125 Irwin R S, French C L, Curley F J. et al . Chronic Cough Due To Gastroesophageal Reflux. Clinical, diagnostic, and pathogenetic aspects (see comments).  Chest. 1993;  104 (5) 1511-1517
  • 126 Ours T M, Kavuru M S, Schilz R J. et al . A prospective evaluation of esophageal testing and a double-blind, randomized study of omeprazole in a diagnostic and therapeutic algorithm for chronic cough.  Am J Gastroenterol. 1999;  94 (11) 3131-3138
  • 127 Jaspersen D, Diehl K L, Weber R. Diagnostischer Omeprazoltest bei Verdacht auf refluxassoziierten chronisch persistierenden Husten.  Pneumologie. 1999;  53 (3) S64
  • 128 Vaezi M F, Richter J E. Twenty-four-hour Ambulatory Esophageal PH Monitoring In the diagnosis of acid reflux-related chronic cough.  South Med J. 1997;  90 (3) 305-311
  • 129 Lazenby J P, Harding S M. Chronic cough, asthma, and gastroesophageal reflux.  Curr Gastroenterol Rep. 2000;  2 (3) 217-223
  • 130 Fraser A G, Morton R P, Gillibrand J. Presumed laryngo-pharyngeal reflux: investigate or treat?.  J Laryngol Otol. 2000;  114 (6) 441-447
  • 131 Leite L P, Johnston B T, Just R J. et al . Persistent acid secretion during omeprazole therapy: a study of gastric acid profiles in patients demonstrating failure of omeprazole therapy.  Am J Gastroenterol. 1996;  91 (8) 1527-1531
  • 132 Katzka D A, Paoletti V, Leite L. et al . Prolonged ambulatory pH monitoring in patients with persistent gastroesophageal reflux disease symptoms: testing while on therapy identifies the need for more aggressive anti-reflux therapy.  Am J Gastroenterol. 1996;  91 (10) 2110-2113
  • 133 Johnston B T, Gideon R M, Castell D O. Excluding gastroesophageal reflux disease as the cause of chronic cough.  J Clin Gastroenterol. 1996;  22 (3) 168-169
  • 134 Irwin R S. Silencing chronic cough.  Hosp Pract (Off Ed). 1999;  34 (1) 53-30
  • 135 Irwin R S, Zawacki J K, Wilson M M. et al . Chronic cough due to gastroesophageal reflux disease: failure to resolve despite total/near-total elimination of esophageal acid.  Chest. 2002;  121 (4) 1132-1140
  • 136 Novitsky Y W, Zawacki J K, Irwin R S. et al . Chronic cough due to gastroesophageal reflux disease: efficacy of antireflux surgery.  Surg Endosc. 2002;  16 (4) 567-571
  • 137 McGarvey L P, Forsythe P, Heaney L G. et al . Bronchoalveolar lavage findings in patients with chronic nonproductive cough.  Eur Respir J. 1999;  13 (1) 59-65
  • 138 Lee S Y, Cho J Y, Shim J J. et al . Airway inflammation as an assessment of chronic nonproductive cough.  Chest. 2001;  120 (4) 1114-1120
  • 139 Nelson S, Summer W R, Mason C M. The role of the inflammatory response in chronic bronchitis: therapeutic implications.  Semin Respir Infect. 2000;  15 (1) 24-31
  • 140 Kanner R E, Connett J E, Williams D E. et al . Effects of randomized assignment to a smoking cessation intervention and changes in smoking habits on respiratory symptoms in smokers with early chronic obstructive pulmonary disease: the Lung Health Study.  Am J Med. 1999;  106 (4) 410-416
  • 141 Krzyzanowski M, Robbins D R, Lebowitz M D. Smoking cessation and changes in respiratory symptoms in two populations followed for 13 years.  Int J Epidemiol. 1993;  22 (4) 666-673
  • 142 Tashkin D P, Clark V A, Coulson A H. et al . The UCLA population studies of chronic obstructive respiratory disease. VIII. Effects of smoking cessation on lung function: a prospective study of a free-living population.  Am Rev Respir Dis. 1984;  130 (5) 707-715
  • 143 Kastelik J A, Jackson W, Davies T W. et al . Measurement of Gastric Emptying in Gastroesophageal Reflux-Related Chronic Cough.  Chest. 2002;  122 (6) 2038-2041
  • 144 Fujimoto T, Hillejan L, Stamatis G. Current strategy for surgical management of bronchiectasis.  The Annals of Thoracic Surgery. 2001;  72 (5) 1711-1715
  • 145 Kutlay H, Cangir A K, Enon S. et al . Surgical treatment in bronchiectasis: analysis of 166 patients.  European Journal of Cardio-Thoracic Surgery. 2002;  21 (4) 634-637
  • 146 Agasthian T, Deschamps C, Trastek V F. et al . Surgical Management of Bronchiectasis.  The Annals of Thoracic Surgery. 1996;  62 (4) 976-978
  • 147 Prieto D, Bernardo J, Matos M J. et al . Surgery for bronchiectasis.  European Journal of Cardio-Thoracic Surgery. 2001;  20 (1) 19-24
  • 148 Morice A H, Lowry R, Brown M J. et al . Angiotensin-converting enzyme and the cough reflex.  Lancet. 1987;  2 (8568) 1116-1118
  • 149 Fuller R W. Cough provocation tests: their clinical value.  Pulm Pharmacol Ther. 2002;  15 (3) 273-276
  • 150 Birring S S, Brightling C, Symon F. et al . Idiopathic chronic cough: association with organ specific autoimmune disease and bronchoalveolar lymphocytosis.  Thorax. 2003;  58 1066-1070
  • 151 Lee P C, Cotterill J, Eccles R. Voluntary control of cough.  Pulm Pharmacol Ther. 2002;  15 (3) 317-320
  • 152 French C, Irwin R S, Curley F G. et al . Impact of chronic cough on quality of life.  Arch Intern Med. 1998;  158 (15) 1657-1661
  • 153 Choudry N O, Fuller R W, Pride N B. Sensitivity of the human cough reflex: effect of inflammatory mediators prostaglandin E2, bradykinin, and histamine.  Am Rev Respir Dis. 1989;  140 (1) 137-141
  • 154 Israili Z H, Hall W D. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy. A review of the literature and pathophysiology.  Ann Intern Med. 1992;  117 (3) 234-242
  • 155 Lacourciere Y, Brunner H, Irwin R. et al . Effects of modulators of the renin-angiotensin-aldosterone system on cough. Losartan Cough Study Group.  J Hypertens. 1994;  12 (12) 1387-1393
  • 156 Imaizumi H, Kaneko M, Mori K. et al . Reversible acquired tracheobronchomalacia of a combined crescent type and saber-sheath type.  J Emerg Med. 1995;  13 (1) 43-49
  • 157 Gibson P G, Dolovich J, Denburg J. et al . Chronic Cough: Eosinophilic Bronchitis Without Asthma.  Lancet. 1989;  1 (8651) 1346-1348
  • 158 Kardos P. Eosinophile Bronchitis ohne Asthma: eine weitere seltene Ursache für chronisch persistierenden Husten?.  Pneumologie. 2001;  55 (5) 249-252
  • 159 Kujat A, Gillissen A, Zuber M A. Genetische Diagnose und Beratung bei Bronchiektasie. Erstdiagnose der zystischen Fibrose bei Erwachsenen.  Dtsch Med Wochenschr. 2002;  127 (10) 501-502
  • 160 Macfarlane J, Holmes W, Gard P. et al . Prospective study of the incidence, aetiology and outcome of adult lower respiratory tract illness in the community.  Thorax. 2001;  56 109-104
  • 161 Verheij T J, Hermans J, Mulder J D. Effects of doxycycline in patients with acute cough and purulent sputum: a double blind placebo controlled trial.  Br J Gen Pract. 1994;  44 (386) 400-404
  • 162 Morice A H, Widdicombe J, Dicpinigaitis P. et al . Understanding cough.  Eur Respir J. 2002;  19 (1) 6-7
  • 163 Mortensen J, Falk M, Groth S. et al . The effects of postural drainage and positive expiratory pressure physiotherapy on tracheobronchial clearance in cystic fibrosis.  Chest. 1991;  100 (5) 1350-1357
  • 164 Gosselink R. Therapie, Training, Tests. van den Berg F.  Angewandte Physiologie. 2001;  (3) 275-276
  • 165 Hardy K A, Anderson B D. Noninvasive clearance of airway secretions.  Respir Care Clin N Am. 1996;  2 (2) 323-345
  • 166 Jones A, Rowe B. Bronchopulmonary hygiene physical therapy for chronic obstructive pulmonary disease and bronchiectasis.  The Cochrane Library. 2002;  2 Letzte update 01.2003
  • 167 Rubin B K. The pharmacologic approach to airway clearance: mucoactive agents.  Respir Care. 2002;  47 (7) 818-822
  • 168 Mazzocco M C, Owens G R, Kirilloff L H. et al . Chest percussion and postural drainage in patients with bronchiectasis.  Chest. 1985;  88 (3) 360-363
  • 169 Gallon A. Evaluation of chest percussion in the treatment of patients with copious sputum production.  Respir Med. 1991;  85 (1) 45-51
  • 170 Sutton P P, Lopez V, Pavia D. et al . Assessment of percussion, vibratory-shaking and breathing exercises in chest physiotherapy.  Eur J Respir Dis. 1985;  66 (2) 147-152
  • 171 Sutton P P, Parker R A, Webber B A. et al . Assessment of the forced expiration technique, postural drainage and directed coughing in chest physiotherapy.  Eur J Respir Dis. 1983;  64 (1) 62-68
  • 172 Lannefors L, Wollmer P. Mucus clearance with three chest physiotherapy regimes in cystic fibrosis: a comparison between postural drainage, PEP and physical exercise.  Eur Respir J. 1992;  5 (6) 748-753
  • 173 Miller S, Hall D O, Clayton C B. et al . Chest physiotherapy in cystic fibrosis: a comparative study of autogenic drainage and the active cycle of breathing techniques with postural drainage.  Thorax. 1995;  50 (2) 165-169
  • 174 Lauber B, Lauber J. Krankengymnastische Atemtherapie.  Nolte D Manuale Pneumologicum. 1992;  (IV-12) 7
  • 175 Cegla U H, Retzow A. Physiotherapy mit VRP1 bei chronisch obstruktiven Atemwegserkrankungen. Ergebnisse einer multizentrischen Vergleichsstudie.  Pneumologie. 1993;  47 (11) 636-639
  • 176 Thompson C S, Harrison S, Ashley J. et al . Randomised crossover study of the Flutter device and the active cycle of breathing technique in non-cystic fibrosis bronchiectasis.  Thorax. 2002;  57 (5) 446-448
  • 177 Cegla U H, Bautz M, Frode G. et al . Physiotherapie bei Patienten mt COPD und tracheobronchialer Instabilität. Vergleich von zwei oszillierenden PEP Systemen (RC-Cornet, VRP1 Desitin). Ergebnisse einer randomisierten, prospektiven Studie mit 90 Patienten.  Pneumologie. 1997;  51 (2) 129-136
  • 178 Hausen T. Therapie von obstruktiven Atemwegserkrankungen.  MMW-Fortschr Med. 1991;  46 700-703
  • 179 Lurie A, Mestiri M, Huchon G. et al . Methods for clinical assessment of expectorants: a critical review.  Int J Clin Pharmacol Res. 1992;  12 (1) 47-52
  • 180 Gillissen A, Tasci S, Ewig S. et al . Sinn und Unsinn von Antitussiva.  Internist (Berl). 2001;  42 (1) 134-142
  • 181 Rubin B K. The pharmacologic approach to airway clearance: mucoactive agents.  Respir Care. 2002;  47 (7) 818-822
  • 182 Schroeder K, Fahey T. Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults.  BMJ. 2002;  324 (7333) 329
  • 183 Ziment I. Herbal antitussives.  Pulm Pharmacol Ther. 2002;  15 (3) 327-333
  • 184 Köhler D. Inhalationstherapie bei chronischer Schleimretention.  Pneumologie. 1990;  44 (10) 1166-1170
  • 185 Haidl P, Schonhofer B, Siemon K. et al . Inhaled isotonic alkaline versus saline solution and radioaerosol clearance in chronic cough.  Eur Respir J. 2000;  16 (6) 1102-1108
  • 186 Laube B L, Auci R M, Shields D E. et al . Effect of rhDNase on airflow obstruction and mucociliary clearance in cystic fibrosis.  Am J Respir Crit Care Med. 1996;  153 (2) 752-760
  • 187 Robinson P J. Dornase alfa in early cystic fibrosis lung disease.  Pediatr Pulmonol. 2002;  34 (3) 237-241
  • 188 Ghafouri M A, Patil K D, Kass I. Sputum changes associated with the use of ipratropium bromide.  Chest. 1984;  86 (3) 387-393
  • 189 Holmes P W, Barter C E, Pierce R J. Chronic persistent cough: use of ipratropium bromide in undiagnosed cases following upper respiratory tract infection.  Respir Med. 1992;  86 (5) 425-429
  • 190 Lowry R, Wood A, Johnson T. et al . Antitussive properties of inhaled bronchodilators on induced cough.  Chest. 1988;  93 (6) 1186-1189
  • 191 Higenbottam T W. Anticholinergics and cough.  Postgrad Med J. 1987;  63 Suppl 1 75-78
  • 192 Shore S C, Weinberg E G. Ipratropium bromide inhalation for allergic rhinitis and chronic cough.  S Afr Med J. 1981;  59 (8) 252
  • 193 Tay H L, Armoogum N, Tan L K. Nasal mucociliary clearance and salmeterol.  Clin Otolaryngol. 1997;  22 (1) 68-70
  • 194 Mortensen J, Lange P, Nyboe J. et al . Lung mucociliary clearance.  Eur J Nucl Med. 1994;  21 (9) 953-961
  • 195 Hueston W. A comparison of albuterol and erythromycin for the treatment of acute bronchitis.  J Fam Pract. 1991;  33 (5) 476-480
  • 196 Smucny J J, Flynn C A, Becker L A. et al . Are β2-agonists effective treatment for acute bronchitis or acute cough in patients without underlying pulmonary disease? A systematic review.  J Fam Pract. 2001;  50 (11) 945-951
  • 197 Curley F J, Irwin R S, Pratter M R. et al . Cough and the common cold.  Am Rev Respir Dis. 1988;  138 (2) 305-311
  • 198 Corrao W M. Chronic Persistent Cough: Diagnosis and treatment update.  Pediatr Ann. 1996;  25 (3) 162-168
  • 199 Pratter M R, Bartter T, Akers S. et al . An Algorithmic approach to chronic cough.  Ann Intern Med. 1993;  119 (10) 977-983
  • 200 Angrill J, Agusti C, De Celis R. et al . Bronchial Inflammation and Colonization in Patients with Clinically Stable Bronchiectasis.  American Journal of Respiratory and Critical Care Medicine. 2001;  164 (9) 1628-1632
  • 201 Schaefer O, Irwin R. Chronic cough due to clinically silent suppurative disease of the airways: a new clinical entity (abstract).  Am J Respir Crit Care Med. 1999;  159 (Part 2) A830
  • 202 Barker A F, Couch L ESL, Fiel S B. et al . Tobramycin Solution for Inhalation Reduces Sputum Pseudomonas aeruginosa Density in Bronchiectasis.  American Journal of Respiratory and Critical Care Medicine. 2000;  162 (2) 481-485
  • 203 Ramsey B W, Pepe M S, Quan J M. et al . Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. Cystic Fibrosis Inhaled Tobramycin Study Group.  The New England Journal of Medicine. 1999;  340 (1) 23-30
  • 204 Kalliomaki M, Salminen S, Arvilommi H. et al . Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial.  Lancet. 2001;  357 (9262) 1076-1079
  • 205 Tamm M, Eich C, Frei R. et al . Inhalierbares Colistin bei zystischer Fibrose.  Schweiz Med Wochenschr. 2000;  130 (39) 1366-1372
  • 206 Laitinen L A, Laitinen A, Haahtela T. A comparative study of the effects of an inhaled corticosteroid, budesonide, and a β2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial.  J Allergy Clin Immunol. 1992;  90 (1) 32-42
  • 207 Higenbottam T. Cough induced by changes of ionic composition of airway surface liquid.  Bull Eur Physiopathol Respir. 1984;  20 (6) 553-562
  • 208 Chan P W, Debruyne J A. Inhaled nedocromil sodium for persistent cough in children.  Med J Malaysia. 2001;  56 (4) 408-413
  • 209 Young I H. Nedocromil sodium (Tilade) metered aerosol in the treatment of chronic cough.  Med J Aust. 1996;  164 (12) 755
  • 210 Moroni M, Porta C, Gualtieri G. et al . Inhaled sodium cromoglycate to treat cough in advanced lung cancer patients.  Br J Cancer. 1996;  74 (2) 309-311
  • 211 Dicpinigaitis P V, Dobkin J B, Reichel J. Antitussive effect of the leukotriene receptor antagonist zafirlukast in subjects with cough-variant asthma.  J Asthma. 2002;  39 (4) 291-297
  • 212 Hansson L, Midgren B, Karlsson J A. Effects of inhaled lignocaine and adrenaline on capsaicin-induced cough in humans.  Thorax. 1994;  49 (11) 1166-1168
  • 213 Karlsson J A. Airway anaesthesia and the cough reflex.  Bull Eur Physiopathol Respir. 1987;  23 Suppl 10 29s-36s
  • 214 Fuller R W, Jackson D M. Physiology and treatment of cough.  Thorax. 1990;  45 (6) 425-430
  • 215 Fuller R W, Karlsson J A, Choudry N B. et al . Effect of inhaled and systemic opiates on responses to inhaled capsaicin in humans.  J Appl Physiol. 1988;  65 (3) 1125-1130
  • 216 Eccles R. The powerful placebo in cough studies?.  Pulm Pharmacol Ther. 2002;  15 (3) 303-308
  • 217 Taylor J A, Novack A H, Almquist J R. et al . Efficacy of cough suppressants in children.  J Pediatr. 1993;  122 (5 Pt 1) 799-802
  • 218 Eccles R, Morris S, Jawad M. Lack of effect of codeine in the treatment of cough associated with acute upper respiratory tract infection.  J Clin Pharm Ther. 1992;  17 (3) 175-180
  • 219 Dicpinigaitis P V, Rauf K. Treatment of chronic, refractory cough with baclofen.  Respiration. 1998;  65 (1) 86-88
  • 220 Dicpinigaitis P V, Dobkin J B. Antitussive effect of the GABA-agonist baclofen.  Chest. 1997;  111 (4) 996-999
  • 221 Irwin R S, Curley F J. The treatment of cough. A comprehensive review.  Chest. 1991;  99 (6) 1477
  • 222 George L, Rehman S U, Khan F A. Diaphragmatic rupture: A complication of violent cough.  Chest. 2000;  117 (4) 1200-1201
  • 223 Prasad S, Baur L A. Fracture of the first rib as a consequence of pertussis infection.  J Paediatr Child Health. 2001;  37 (1) 91-93
  • 224 De Maeseneer M, De Mey J, Debaere C. et al . Rib fractures induced by coughing: an unusual cause of acute chest pain.  Am J Emerg Med. 2000;  18 (2) 194-197
  • 225 Mattle H P, Nirkko A C, Baumgartner R W. et al . Transient cerebral circulatory arrest coincides with fainting in cough syncope.  Neurology. 1995;  45 (3 Pt 1) 498-501
  • 226 Tanaka T, Inoue H, Aizawa H. et al . Case of cough syncope with seizure.  Respiration. 1994;  61 (1) 48-50
  • 227 Kopp I, Müller W, Lorenz W. Die zentrale Rolle von Outcome in Leitlinien und Disease-Management Programmen. 8. Rundbrief. AWMF online 2003: 1-10

Dr. med. Peter Kardos

Scheffelstraße 33

60318 Frankfurt am Main

Email: Kardos@lungenpraxis-maingau.de

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