Facial Hemangioma, and Associated Malformations: A Case Report

Abstract

Facial hemangioma can be isolated lesions or associated with a wide variety of systemic findings. We report a 9-month-old girl who shows an extensive facial hemangioma, intracranial and extracranial vascular malformations, a Dandy-Walker malformation and congenital cardiac malformations. This patient serves as an ample reason why children with similar cutaneous lesions should be carefully evaluated for other associated defects.

Key words

Neurocutaneous disease - facial hemangioma - Dandy-Walker malformation - cutaneous hemangioma-vascular complex syndrome - PHACES - Pascual-Castroviejo II syndrome

References

• 1 Aeby A, Guerrini R, David P, Rodesch G, Raybaud C, Van Bogaert P. Facial hemangioma and cerebral corticovascular dysplasia, a syndrome associated with epilepsy.  Neurology. 2003;  60 1030-1032
• 2 Blei F, Walter J, Orlow S J, Marchuk D A. Familial segregation of hemangiomas and vascular malformations as an autosomal dominant trait.  Arch Dermatol. 1998;  134 718-722
• 3 Frieden I J, Reese V, Cohen D. PHACE syndrome: the association of posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities.  Arch Dermatol. 1996;  132 307-311
• 4 Holden K R, Alexander F. Diffuse neonatal hemangiomatosis.  Pediatrics. 1970;  46 411-421
• 5 Metry D W, Dowd C F, Barkovich A J, Frieden I J. The many faces of PHACE syndrome.  J Pediatr. 2001;  139 117-123
• 6 Mulliken J B, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics.  Plast Reconstr Surg. 1982;  69 412-420
• 7 Pascual-Castroviejo I. Vascular and nonvascular intracranial malformations associated with external capillary hemangiomas.  Neuroradiology. 1978;  16 82-84
• 8 Pascual-Castroviejo I, Viano J, Pascual-Pascual S I, Martinez V. Facial hemangioma, agenesis, of the internal carotid artery and dysplasia of cerebral cortex: case report.  Neuroradiology. 1995;  37 692-695
• 9 Pascual-Castroviejo I, Viano J, Moreno F, Palencia R, Martinez-Fernandez V, Pascual-Pascual S I. et al . Hemangiomas of the head, neck, and chest with associated vascular and brain anomalies: A complex neurocutaneous syndrome.  Am J Neuroradiol. 1996;  17 461-471
• 10 Pascual-Castroviejo I, Lopez-Gutierrez J C, Pascual-Pascual S I, Rafia S, Alarcon-Palacio J. Hemangiomas y malformaciones vasculares cutaneas y patologia asociada. Un nuevo sindrome neurocutaneo.  An Pediatr (Barc). 2003;  58 339-349
• 11 Pascual-Castroviejo I, Viano J, Pascual-Pascual S I, Martinez V. Do cutaneous hemangiomas and internal vascular anomalies follow the same evolution?.  Neurology. 2003;  61 140-141
• 12 Torres-Mohedas J, Verdu A, Vidal B, Jadraque R. Presentacion conjunta de hemangioma facial, malformacion de fosa posterior e hipoplasia carotido-vertebral (sindrome de Pascual-Castroviejo II): aportacion de dos nuevos casos.  Rev Neurol (Barcelona). 2001;  32 50-54
• 13 Volpe J J. Neurology of the Newborn. Philadelphia; WB Saunders Company 2001: 34-36

1 The first two authors contributed equally to this work.