Planta Med 2004; 70(1): 81-84
DOI: 10.1055/s-2004-815464
Letter
© Georg Thieme Verlag Stuttgart · New York

Pubescenes, Jatrophane Diterpenes, from Euphorbia pubescens, with Multidrug Resistance Reversing Activity on Mouse Lymphoma Cells

Cláudia Valente1 , Maria José U. Ferreira1 , Pedro M. Abreu2 , Nora Gyémánt3 , Katalin Ugocsai3 , Judit Hohmann4 , Joseph Molnár3
  • 1Centro de Estudos de Ciências Farmacêuticas, Faculdade de Farmácia da Universidade de Lisboa, Lisboa, Portugal
  • 2CQFB/REQUIMTE, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, Caparica, Portugal
  • 3Department of Medical Microbiology, University of Szeged, Szeged, Hungary
  • 4Department of Pharmacognosy, University of Szeged, Szeged, Hungary
This work was supported by FCT (POCTI, Quadro Comunitário de Apoio III; grant: SFRH/BM/161/2000)
Further Information

Publication History

Received: May 30, 2003

Accepted: August 24, 2003

Publication Date:
06 February 2004 (online)

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Abstract

The macrocyclic jatrophane diterpene polyesters, pubescenes A - D (1 - 4) were isolated from the whole dried plant of Euphorbia pubescens, and evaluated for multidrug resistance (MDR) reversing activity on mouse lymphoma cells. All the compounds displayed very strong activity compared with the positive control verapamil. Pubescene D (4) is a new compound, whose structure was established as 3β,9α,-diacetoxy-7β-benzoyloxy-15β-hydroxy-14-oxo-2βH-jatropha-5E,12E-diene by spectroscopic methods, including 1H-1H COSY, HMQC, HMBC and NOESY.

References

Prof. Maria José Umbelino Ferreira

Centro de Estudos de Ciências Farmacêuticas

Faculdade de Farmácia da Universidade de Lisboa

Av. das Forças Armadas

1600-083 Lisboa

Portugal

Fax: +351-21-7946470

Email: mjuferreira@ff.ul.pt