Pharmacopsychiatry 2003; 36 - 145
DOI: 10.1055/s-2003-825396

Association of clinical and non-clinical factors with subjective well-being – data of the SOHO study

A Karow 1, A Ritzhaupt 2, F Roesch 2, D Novick 3, D Naber 1, RW Dittmann 2
  • 1Psychiatric Department, University of Hamburg, Germany
  • 2Medical Department, Division of Neuroscience/Lilly Deutschland GmbH, Bad Homburg, Germany
  • 3Lilly Research Centre, Windlesham Surrey, UK

The European Schizophrenia Outpatient Health Outcomes (SOHO) study in Germany investigated the association of different clinical and non-clinical variables with changes in subjective well-being in schizophrenia patients with neuroleptic treatment.

All statistical analyses were carried out including side-effects (e.g. weight gain, sexual functioning), compliance (physician and patient rated), schizophrenia symptoms, and quality of life (e.g. EQM, EQSC) at baseline and 6-months.

The analysis of the SWN change scores (% and absolute), stratified by changes in patients’ compliance, revealed that patients with an improvement in compliance reported the highest change in SWN (24.1%), patients with no change in compliance showed a lower SWN change (16.7%), and patients with a deterioration in compliance showed the lowest SWN change (2.9%). A factor analysis of a variety of clinical and non-clinical variables revealed 4 separate factors (side effects, compliance, clinical symptoms and quality of life). The statistical model (ANCOVA) showed a significant effect of the factor compliance on changes in the SWN (p<0.001).

Results of this naturalistic study demonstrated that an improvement in compliance with neuroleptic treatment, either reported by the patient or the physician, was associated with better subjective well-being.