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Association of clinical and non-clinical factors with subjective well-being – data of the SOHO study
The European Schizophrenia Outpatient Health Outcomes (SOHO) study in Germany investigated the association of different clinical and non-clinical variables with changes in subjective well-being in schizophrenia patients with neuroleptic treatment.
All statistical analyses were carried out including side-effects (e.g. weight gain, sexual functioning), compliance (physician and patient rated), schizophrenia symptoms, and quality of life (e.g. EQM, EQSC) at baseline and 6-months.
The analysis of the SWN change scores (% and absolute), stratified by changes in patients’ compliance, revealed that patients with an improvement in compliance reported the highest change in SWN (24.1%), patients with no change in compliance showed a lower SWN change (16.7%), and patients with a deterioration in compliance showed the lowest SWN change (2.9%). A factor analysis of a variety of clinical and non-clinical variables revealed 4 separate factors (side effects, compliance, clinical symptoms and quality of life). The statistical model (ANCOVA) showed a significant effect of the factor compliance on changes in the SWN (p<0.001).
Results of this naturalistic study demonstrated that an improvement in compliance with neuroleptic treatment, either reported by the patient or the physician, was associated with better subjective well-being.