Subscribe to RSS
Association study of SNPs in G72 and DAAO in schizophrenia
Purpose: Schizophrenia, affecting 1% of the population, is considered a highly heritable disease. Polymorphisms in the two genes G72, located on human chromosome 13q34, and DAAO, located on chromosome 12q24, have been found to be associated with schizophrenia (1).
Methods: To confirm these findings, we analyzed SNPs in the G72 and DAAO genes in a case-control association study of 307 schizophrenic patients and 418 controls. The first group consisted of male and female Caucasian patients with schizophrenia of the undifferentiated, disorganized or paranoid type according to DSM-IV criteria. Patients were between 18 and 65 years old. Exclusion criteria for the patients were dependence from alcohol or legal and illicit drugs. Particular care was taken to exclude patients with somatic diseases, which might cause psychotic symptoms and thus complicate the diagnostic classification. The control group consisted of unrelated and unaffected Caucasians. Exclusion criteria for controls were major neuropsychiatric diseases.
Results: Preliminary results confirm the involvement of the DAAO locus in schizophrenia. The results on G72 will be discussed.
Chumakov, Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia, 2002