Pharmacopsychiatry 2003; 36 - 57
DOI: 10.1055/s-2003-825308

Efficacy and safety of atomoxetine in adults with attention deficit/hyperactivity disorder

RW Dittmann 1, 2, L Adler 3, D Michelson 4, J Wernicke 4
  • 1Psychosomatic Department, Children’s Hospital, University of Hamburg, Germany
  • 2Medical Department, Lilly Deutschland GmbH, Germany
  • 3Department of Clinical Psychiatry, New York Univ. School of Medicine, USA
  • 4Eli Lilly and Company, Indianapolis, USA

This poster presents efficacy, safety/tolerability data for atomoxetine in the treatment of adults with Attention-Deficit/Hyperactivity Disorder (ADHD). Atomoxetine is a nonstimulant medication recently approved in the US as a treatment for ADHD in children, adolescents and adults.

Atomoxetine has been studied in 2 identical, acute, randomized, double-blind, placebo-controlled studies (Study 1: n=141, Study 2: n=129) and 1 long-term open-label extension study (n=384) in adults with ADHD. Efficacy was measured utilizing the Conners’ Adult ADHD Rating Scale and Clinician Global Impression of Severity. Safety was assessed by open-ended questioning and adverse event reports.

Atomoxetine was superior to placebo in reducing core ADHD symptoms. Patients that continued atomoxetine treatment in the open-label trial continued to experience symptom improvement. Atomoxetine was well-tolerated with a low rate of discontinuations due to adverse events (7.8%) in the open-label extension study.

Atomoxetine appears to be efficacious and safe in the treatment of ADHD in adults.


Michelson D et al. Biol Psychiatry 2003; 53:112–120