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Serum and cerebrospinal fluid concentration of Substance P before and after treatment of depressed patients
Substance P (SP) is considered to be involved in the pathophysiology of depression. In 80 depressed patients, we measured serum SP after washout of pre-treatment, after 2 and 4 weeks of treatment with amitriptyline and paroxetine. Additionally, SP was measured in the cerebrospinal fluid of 12 patients before and after treatment. Independent of clinical response and medication, SP serum concentrations did not change during treatment. Serum and CSF SP concentrations were not related and CSF concentrations of SP did not change during treatment. Our data indicate that SP in serum may not validly reflect CNS expression of the peptide and that SP concentrations show no major changes due to antidepressant treatment.