Abstract
Oral administration of the MeOH extract of Rhus verniciflua or of an EtOAc fraction containing an EtOAc-soluble portion of the MeOH extract slightly
decreased rheumatoid arthritis (RA) and C-reactive protein (CRP) factors in Freund's
complete adjuvant reagent FCA-treated rats, indicating that they are active extracts
for rheumatoid arthritis, the EtOAc extract being more active. Treatment with these
two extracts prevented histological changes such as synovial cell proliferation, inflammatory
cell infiltration and fat necrosis compared with an FCA-treated group. Oral administration
(30 mg/kg) of sulfuretin and fustin, which were isolated from the EtOAc extract by
activity-guided separation, significantly decreased RA and CRP factors, the former
being more active than the latter. Treatment with the EtOAc fraction (p. o. ) containing sulfuretin significantly decreased malondialdehyde (MDA) formation, and
highly increased the activities of superoxide dismutase, catalase and glutathione
peroxidase. Inhibition of xanthine oxidase and aldehyde oxidase in FCA-treated rats
was also evident. Since treatment with sulfuretin and the EtOAc extract decreased
the concentration of infiltrated mast cells in the rat knee exhibiting rheumatoid
arthritis, we suggest that the Rhus verniciflua extract, which contains sulfuretin as an active component, may prevent rheumatoid
syndromes by inhibiting reactive oxygen species.
Key words
Rhus verniciflua
- Anacardiaceae - sulfuretin - fustin - aurones - rheumatoid arthritis - antioxidant
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Prof. Associate Hee-Juhn Park
Division of Applied Plant Sciences
Sangji University
Woosan-dong
Wonju 220-702
Korea
Telefon: +82-+33-730-0564
Fax: +82-+33-730-0564
eMail: hjpark@mail.sangji.ac.kr