Planta Med 2003; 69(8): 757-764
DOI: 10.1055/s-2003-42796
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Anti-Platelet Aggregation and Chemical Constituents from the Rhizome of Gynura japonica

Wei-Yu Lin1 , Yueh-Hsiung Kuo2 , Ya-Ling Chang3 , Che-Ming Teng3 , Eng-Chi Wang4 , Tsutomu Ishikawa5 , Ih-Sheng Chen1
  • 1Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
  • 2Department of Chemistry, National Taiwan University, Taipei, Taiwan, Republic of China
  • 3Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
  • 4School of Chemistry, College of Life Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
  • 5Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan
This research was supported financially by the National Science Council of R.O.C.
Weitere Informationen

Publikationsverlauf

Received: December 10, 2002

Accepted: May 2, 2003

Publikationsdatum:
06. Oktober 2003 (online)

Abstract

A novel quinonoid terpenoid, (-)-α-tocospirone, a new chromanone, (-)-gynuraone, as well as three new steroids, (22E,24S)-7α-hydroperoxystigmasta-5,22-dien-3β-ol, (22E,24S)-stigmasta-1,4,22-trien-3-one, and (24R)-stigmasta-1,4-dien-3-one, together with 15 known components, were isolated from the rhizome of Formosan Gynura japonica. Structures of the new compounds were determined through spectral analyses and chemical evidence. Several of the isolated compounds, caryophyllene oxide, 6-acetyl-2,2-dimethylchroman-4-one, vanillin, 2,6-dimethoxy-1,4-benzoquinone, and benzoic acid exhibited significant anti-platelet aggregation activity in vitro.

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Prof. Dr. I. S. Chen

Graduate Institute of Pharmaceutical Sciences

Kaohsiung Medical University

Kaohsiung

Taiwan 807

Republic of China

Telefon: +886-7-3121101 ext 2123

Fax: +886-7-3210683

eMail: m635013@kmu.edu.tw