Planta Med 2003; 69(8): 757-764
DOI: 10.1055/s-2003-42796
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Anti-Platelet Aggregation and Chemical Constituents from the Rhizome of Gynura japonica

Wei-Yu Lin1 , Yueh-Hsiung Kuo2 , Ya-Ling Chang3 , Che-Ming Teng3 , Eng-Chi Wang4 , Tsutomu Ishikawa5 , Ih-Sheng Chen1
  • 1Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
  • 2Department of Chemistry, National Taiwan University, Taipei, Taiwan, Republic of China
  • 3Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
  • 4School of Chemistry, College of Life Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
  • 5Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan
This research was supported financially by the National Science Council of R.O.C.
Further Information

Publication History

Received: December 10, 2002

Accepted: May 2, 2003

Publication Date:
06 October 2003 (online)


A novel quinonoid terpenoid, (-)-α-tocospirone, a new chromanone, (-)-gynuraone, as well as three new steroids, (22E,24S)-7α-hydroperoxystigmasta-5,22-dien-3β-ol, (22E,24S)-stigmasta-1,4,22-trien-3-one, and (24R)-stigmasta-1,4-dien-3-one, together with 15 known components, were isolated from the rhizome of Formosan Gynura japonica. Structures of the new compounds were determined through spectral analyses and chemical evidence. Several of the isolated compounds, caryophyllene oxide, 6-acetyl-2,2-dimethylchroman-4-one, vanillin, 2,6-dimethoxy-1,4-benzoquinone, and benzoic acid exhibited significant anti-platelet aggregation activity in vitro.


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Prof. Dr. I. S. Chen

Graduate Institute of Pharmaceutical Sciences

Kaohsiung Medical University


Taiwan 807

Republic of China

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