© Georg Thieme Verlag Stuttgart · New York
Anti-Platelet Aggregation and Chemical Constituents from the Rhizome of Gynura japonicaThis research was supported financially by the National Science Council of R.O.C.
Received: December 10, 2002
Accepted: May 2, 2003
06 October 2003 (online)
A novel quinonoid terpenoid, (-)-α-tocospirone, a new chromanone, (-)-gynuraone, as well as three new steroids, (22E,24S)-7α-hydroperoxystigmasta-5,22-dien-3β-ol, (22E,24S)-stigmasta-1,4,22-trien-3-one, and (24R)-stigmasta-1,4-dien-3-one, together with 15 known components, were isolated from the rhizome of Formosan Gynura japonica. Structures of the new compounds were determined through spectral analyses and chemical evidence. Several of the isolated compounds, caryophyllene oxide, 6-acetyl-2,2-dimethylchroman-4-one, vanillin, 2,6-dimethoxy-1,4-benzoquinone, and benzoic acid exhibited significant anti-platelet aggregation activity in vitro.
Gynura japonica - Compositae - rhizome - quinonoid diterpene - α-tocospirone - chromanone - gynuraone - steroids - (22E,24S)-7α-hydroperoxystigmasta-5,22-dien-3β-ol - (22E,24S)-stigmasta-1,4,22-trien-3-one - (24R)-stigmasta-1,4-dien-3-one - anti-platelet aggregation
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Graduate Institute of Pharmaceutical Sciences
Kaohsiung Medical University
Republic of China
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