Planta Med 2003; 69(8): 767-770
DOI: 10.1055/s-2003-42794
Letter
© Georg Thieme Verlag Stuttgart · New York

Identification of an Anti-Inflammatory Principle from the Stem Bark of Millettia versicolor

Maurice Tagatsing Fotsing1 , Emmanuel Yankep1 , Dieudonné Njamen2 , Z. Tanee Fomum1 , Barthelemy Nyasse1 , B. Bodo3 , M. Carmen Recio4 , Rosa M. Giner4 , José-Luis Ríos4
  • 1Department of Organic Chemistry, University of Yaounde 1, Yaounde, Cameroon
  • 2Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, Yaounde, Cameroon
  • 3Laboratoire de Chimie U.RA. 401, CNRS, Museum National d'Histoire Naturelle, Paris, France
  • 4Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Burjassot (Valencia), Spain
Part 12 of the series Milletia of Cameroon
Further Information

Publication History

Received: December 16, 2002

Accepted: April 26, 2003

Publication Date:
06 October 2003 (online)

Abstract

The dichloromethane-soluble fraction of the methanol extract of the stem bark of Millettia versicolor Welw. (Leguminosae) has been shown to possess anti-inflammatory activity. The chromatographic fractionation and subsequent analysis of the spectroscopic data of this extract led to the isolation and identification of 2-acetyl-7-methoxynaphtho[2,3-b]furan-4,9-quinone (1) along with two known quinones. Pharmacological data demonstrate that compound 1 has relevant anti-inflammatory properties whereas the other two isolated compounds do not.

References

J. L. Ríos

Departament de Farmacologia

Facultat de Farmàcia

Universitat de València

Vicent Andrés Estellés s/n

46100 Burjassot (Valencia)

Spain

Phone: /Fax: +34-963-544-973

Email: riosjl@uv.es