Planta Med 2003; 69(8): 776-777
DOI: 10.1055/s-2003-42782
Letter
© Georg Thieme Verlag Stuttgart · New York

Antitubercular Cassane Furanoditerpenoids from the Roots of Caesalpinia pulcherrima

Netnapa Promsawan1 , Prasat Kittakoop2 , Surat Boonphong3 , Pakawan Nongkunsarn1
  • 1Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand
  • 2National Center for Genetic Engineering and Biotechnology (BIOTEC), NSTDA, Science Park, Klong Luang, Prathumthani, Thailand
  • 3Department of Chemistry, Faculty of Science, Naresuan University, Pitsanulok, Thailand
Further Information

Publication History

Received: December 10, 2002

Accepted: March 29, 2003

Publication Date:
06 October 2003 (online)

Abstract

Activity-guided fractionation of a root extract of Caesalpinia pulcherrima led to the isolation of two cassane-furanoditerpenoids, 6β-benzoyl-7β-hydroxyvouacapen-5α-ol (1) and 6β-cinnamoyl-7β-hydroxyvouacapen-5α-ol (2). Compound 2 showed strong antitubercular activity with a minimum inhibitory concentration (MIC) of 6.25 μg/mL, whereas the benzoyl analogue (1) was less active (MIC 25 μg/mL). Both compounds expressed moderate cytotoxic activity towards KB (human oral carcinonoid cancer), BC (human breast cancer) and NCl-H187 (small cell lung cancer) cell lines.

References

Dr. Pakawan Nongkunsarn

Department of Chemistry

Faculty of Science

Chiang Mai University

Chiang Mai 50200

Thailand

Fax: +66-5389-2277

Email: pakawan@science.cmu.ac.th