Planta Med 2003; 69(8): 750-756
DOI: 10.1055/s-2003-42780
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Saponins from Schefflera fagueti

Giuseppina Cioffi1 , Alessandra Braca2 , Giuseppina Autore1 , Ivano Morelli2 , Aldo Pinto1 , Fabio Venturella3 , Nunziatina De Tommasi1
  • 1Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano, Salerno, Italy
  • 2Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Pisa, Italy
  • 3Dipartimento di Scienze Farmacologiche, Università di Palermo, Palermo, Italy
Further Information

Publication History

Received: December 2, 2002

Accepted: March 18, 2003

Publication Date:
06 October 2003 (online)

Abstract

Six new lupane (1 - 4) and oleanane saponins (5 and 6) were isolated from the aerial parts of Schefflera fagueti Baill. (Araliaceae). Their structures were determined by 2D-NMR spectroscopy (DQF-COSY, 1D-TOCSY, 2D-HOHAHA, 1D-ROESY, HSQC, HMBC). The antiproliferative activity of compounds 1 - 6 and of their prosapogenins (1a - 6a) was evaluated using three continuous murine and human culture cell lines J774, HEK-293, WEHI-164. Oleanane saponins 5 and 6 were the most active, showing significant inhibitory effects on all cell lines, while their prosapogenins 5a and 6a demonstrated minor activity.

References

Dr. Alessandra Braca

Dipartimento di Chimica Bioorganica e Biofarmacia

Università di Pisa

Via Bonanno, 33

56126 Pisa

Italy

Fax: +39-050-43321

Email: braca@farm.unipi.it