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Am J Perinatol 2003; 20(6): 305-312
DOI: 10.1055/s-2003-42694
Copyright © 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Obstetric Outcomes of Human Immunodeficiency Virus-1-Serodiscordant Couples Following In Vitro Fertilization with Intracytoplasmic Sperm Injection

Jane Cleary-Goldman1 , Joseph E. Peña2 , Melvin H. Thornton II2 , Julian N. Robinson1 , Mary E. D'Alton1 , Mark V. Sauer2
  • 1Division of Maternal-Fetal Medicine, New York Presbyterian Medical Center, College of Physicians and Surgeons, Columbia University, New York, New York
  • 2Division of Reproductive Endocrinology, New York Presbyterian Medical Center, College of Physicians and Surgeons, Columbia University, New York, New York
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Publikationsdatum:
06. Oktober 2003 (online)

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ABSTRACT

The objective of this article is to report obstetric outcomes of human immunodeficiency virus-1 (HIV-1)-serodiscordant couples who underwent in vitro fertilization and embryo transfer (IVF-ET) with intracytoplasmic sperm injection (ICSI) at a tertiary care center. We reviewed the outcomes of seronegative women after IVF-ET with ICSI from January 1, 1997 to June 1, 2002. Serodiscordant couples (n = 25) successfully conceived 27 pregnancies delivering 40 neonates (16 singletons, 9 twins, and 2 triplets). The mean gestational age at delivery was 37 0/7 weeks ± 3 6/7 weeks (range 26 0/7 to 41 2/7 weeks). The mean birth weight was 2646 g ± 952 g (range 678 to 4396 g). The cesarean section rate was 70%. Preterm delivery (<37 weeks) occurred in 7 pregnancies, and low birth weight (<2500 g) was observed in 8 pregnancies. There were no HIV-1 seroconversions detected at delivery. One hundred percent of the mothers and offspring were beyond 3 months postpartum and remained seronegative. IVF-ET with ICSI seems safe and effective for serodiscordant couples. Obstetric outcomes are favorable, and HIV-1 infection risk is limited.

KEYWORDS

HIV serodiscordance - intracytoplasmic sperm injection (ICSI) - human immunodeficiency virus-1 (HIV-1)

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