Palladium-Catalyzed Cyanation Reactions of Thiophene Halides

Thomas Erker; Stephanie Nemec

doi:10.1055/s-2003-42490

SHORTPAPER

Palladium-Catalyzed Cyanation Reactions of Thiophene Halides

Thomas Erker*, Stephanie Nemec
Institute of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
Fax: +43(1)42779551; e-Mail: thomas.erker@univie.ac.at;

Abstract

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Abstract

The described method provides an efficient cyanation reaction of thiophene halides using tris(dibenzylidene-acetone)dipalladium(0), 1,1′-bis-(diphenylphosphino)ferrocene) and zinc powder as the catalyst system and Zn(CN)₂ as the cyanide source. Several thiophenes with various substituents are effectively cyanated under these conditions.

Key words

nitriles - thiophene - palladium - catalysis - cyanation

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Referenzen

References

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