Semin Reprod Med 2003; 21(2): 223-234
DOI: 10.1055/s-2003-41328
Copyright © 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Surgical Management of Endometriosis

David Adamson
  • Fertility Physicians of Northern California Palo Alto San Jose California; Department of Gynecology Obstetrics, Stanford University School of Medicine Stanford,California; Department of Obstetrics Gynecology, and Reproductive Sciences University of California San Francisco California
Further Information

Publication History

Publication Date:
14 August 2003 (online)

ABSTRACT

Surgical management of endometriosis has assumed a prominent role in treating endometriosis-associated infertility and pain. Given the relative lack of prospective, randomized, controlled studies, firm conclusions regarding optimal treatment are difficult. With respect to infertility, the available data generally support surgical management as effective for all stages of disease. Ovarian suppression is usually ineffective and should not be used for endometriosis-associated infertility except in highly selected cases. The management of endometriosis-associated pain usually needs to be multifaceted with surgery being an important, but not the only, component. Except for selected young women responding to ovarian suppression, most patients should have diagnostic laparoscopy with concurrent surgical therapy. The decision to operate depends on clinical judgment, surgeon skill, and individual patient needs. A comprehensive long-term management plan incorporating various treatment modalities should be developed to optimize each patient's management with respect to pain, pelvic masses, and reproductive goals. More studies using sophisticated designs and statistical methods and basic science initiatives in endocrinology, immunology, and genetics are increasingly giving us better insight into endometriosis. With improved knowledge of this complex medical condition, more refined conclusions regarding optimal treatment approaches will become possible and enable clinicians to obtain better outcomes for their patients.

REFERENCES

  • 1 Murphy A. Clinical aspects of endometriosis.  Ann N Y Acad Sci . 2002;  955 1-10
  • 2 Witz C A, Burns W N. Endometriosis and infertility: is there a cause and effect relationship?.  Gynecol Obstet Invest . 2002;  53 (suppl 1) 2-11
  • 3 Nisolle M. Ovarian endometriosis and peritoneal endometriosis: are they different entities from a fertility perspective?.  Curr Opin Obstet Gynecol . 2002;  14 283-288
  • 4 Barbieri R L, Missmer S. Endometriosis and infertility: a cause-effect relationship?.  Ann N Y Acad Sci . 2002;  955 23-33
  • 5 Child T J, Tan S L. Endometriosis: aetiology, pathogenesis and treatment.  Drugs . 2001;  61 1735-1750
  • 6 Cahill D J. What is the optimal medical management of infertility and minor endometriosis?.  <~>Analysis and future prospects. Hum Reprod . 2002;  17 1135-1140
  • 7 Mahutte N G, Arici A. Endometriosis and assisted reproductive technologies: are outcomes affected?.  Curr Opin Obstet Gynecol . 2001;  13 275-279
  • 8 Adamson G D, Hurd S J, Pasta D J, Rodriguez B D. Laparoscopic endometriosis treatment: is it better?.  Fertil Steril . 1993;  59 35-44
  • 9 Hughes E G, Fedorkow D M, Collins J A. A quantitative overview of controlled trials in endometriosis-associated fertility.  Fertil Steril . 1993;  59 963-970
  • 10 Telimaa S, Puolakka J, Ronnberg L, Kauppila A. Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis.  Gynecol Endocrinol . 1987;  1 13-23
  • 11 Henzl M R, Corson S L, Moghissi K. et al . Administration of nasal nafarelin as compared with oral danazol for endometriosis.  N Engl J Med . 1988;  318 485-489
  • 12 Bayer S R, Seibel M M. Medical treatment: danazol. In: Schenken RS, ed. Endometriosis: Contemporary Concepts in Clinical Management Philadelphia: JB Lippincott 1989: 169
  • 13 Schlaff W D, Dugoff L, Damewood M D, Rock J A. Megestrol acetate for treatment of endometriosis.  Obstet Gynecol . 1990;  75 646-648
  • 14 Coutinho E M, Husson J M, Azadian-Boulanger G. Treatment of endometriosis with gestrinone-five years' experience. In: Raynaud J-P, Ojasoo T, Martini L, eds. Medical Management of Endometriosis New York: Raven Press 1984: 249-261
  • 15 Hornstein M D, Yuzpe A, Burry K A. et al . Prospective randomized double-blind trial of three versus six months of nafarelin therapy for endometriosis-associated pelvic pain.  Fertil Steril . 1995;  63 955-962
  • 16 Fedele L, Bianchi S, Arcaini L, Vercellini P, Candiani G B. Buserelin versus danazol in the treatment of endometriosis-associated infertility.  Am J Obstet Gynecol . 1989;  161 871-876
  • 17 Bruhat M A, Mage C, Chapron C. et al . Present-day endoscopic surgery in gynecology.  Eur J Obstet Gynecol Reprod Biol . 1991;  41 4-13
  • 18 Carbon Dioxide Laser Laparoscopy Study Group. Initial report of the carbon dioxide laser laparoscopy study group: complications.  J Gynecol Surg . 1989;  5 269
  • 19 Peterson H B, Hulka J F, Phillips J M. American Association of Gynecologic Laparoscopists' 1988 membership survey on operative laparoscopy.  J Reprod Med . 1990;  35 584-586
  • 20 Luciano A A, Manzi D. Treatment options for endometriosis: surgical therapies.  Infertil Reprod Med Clin North Am . 1992;  3 657-682
  • 21 Redwine D B. Treatment of endometriosis-associated pain.  Infertil Reprod Med Clin North Am . 1992;  3 683-695
  • 22 Adamson G D. Laparoscopic treatment of endometriosis. In: Adamson GD, Martin DC, eds. Endoscopic Management of Gynecologic Disease Philadelphia: Lippincott-Raven 1996: 147-187
  • 23 Olive D L, Pritts E A. The treatment of endometriosis: a review of the evidence.  Ann N Y Acad Sci . 2002;  955 360-372
  • 24 Adamson G D, Frison L, Lamb E J. Endometriosis: studies of a method for design of a surgical staging system.  Fertil Steril . 1982;  38 659-666
  • 25 Fedele L, Parozzini F, Bianchi S, Arcaini L, Candiani G B. Stage and localization of pelvic endometriosis and pain.  Fertil Steril . 1990;  53 155-158
  • 26 Kauppila A, Puolakka J, Ylikorkala O. Prostaglandin biosynthesis inhibitors and endometriosis.  Prostaglandins . 1979;  18 655-661
  • 27 Adamson G D, Pasta D J. Surgical treatment of endometriosis-associated infertility: meta-analysis compared with survival analysis.  Am J Obstet Gynecol . 1994;  171 1488-1505
  • 28 Garcia C D, David S S. Pelvic endometriosis: infertility and pelvic pain.  Am J Obstet Gynecol . 1977;  129 740-747
  • 29 Schenken R S, Malinak LR.. Conservative surgery versus expectant management for the infertile patient with mild endometriosis.  Fertil Steril . 1982;  37 183-186
  • 30 Seibel M M, Berger M J, Weinstein F G, Taymor M L. The effectiveness of danazol on subsequent fertility in minimal endometriosis.  Fertil Steril . 1982;  38 534-537
  • 31 Portuondo J A, Echanojauregui A D, Herran C, Alijarte I. Early conception in patients with untreated mild endometriosis.  Fertil Steril . 1983;  39 22-25
  • 32 Olive D L, Stohs G F, Metzger D A, Franklin R R. Expectant management and hydrotubations in the treatment of endometriosis-associated infertility.  Fertil Steril . 1985;  44 351-352
  • 33 Hull M E, Moghissi K S, Magyar D M, Hayes M F. Comparison of different modalities of endometriosis in infertile women.  Fertil Steril . 1987;  47 40-44
  • 34 Thomas E J, Cooke I D. Successful treatment of asymptomatic endometriosis: does it benefit infertile women?.  Br Med J . 1987;  294 1117-1119
  • 35 Bayer S R, Seibel M M, Saffan D S, Berger M J, Taymor M L. Efficacy of danazol treatment for minimal endometriosis in infertile women. A prospective randomized study.  J Reprod Med . 1988;  33 179-183
  • 36 Rodriguez-Escudero F J, Neyro J L, Corcostegui B, Benito J A. Does minimal endometriosis reduce fecundity?.  Fertil Steril . 1988;  50 522-524
  • 37 Badawy S ZA, El Bakry M M, Samuel F, Dizer M. Cumulative pregnancy rates in infertile women with endometriosis.  J Reprod Med . 1988;  33 757-760
  • 38 Paulson J D, Asmar P, Saffan D S. Mild and moderate endometriosis: comparison of treatment modalities for infertile couples.  J Reprod Med . 1991;  36 151-155
  • 39 Inoue M, Kobayashi Y, Honda I, Awaji H, Fujii A.. The impact of endometriosis on the reproductive outcome of infertile patients.  Am J Obstet Gynecol . 1992;  167 278-282
  • 40 Schenken R S, Malinak L R. Reoperation after initial treatment of endometriosis with conservative surgery.  Am J Obstet Gynecol . 1978;  131 416-424
  • 41 Buttram V C. Conservative surgery for endometriosis in the infertile female: a study of 206 patients with implications for both medical and surgical therapy.  Fertil Steril . 1979;  31 117-123
  • 42 Rantala M L, Kahanpaa K V, Koskimies A I, Widholm O. Fertility prognosis after surgical treatment of pelvic endometriosis.  Acta Obstet Gynaecol Scand . 1983;  62 11-14
  • 43 Gordts S, Boeckx W, Brosens I A. Microsurgery of endometriosis in infertile patients.  Fertil Steril . 1984;  42 520-525
  • 44 Rock J A, Guzick D S, Sengol C. et al . The conservative surgical treatment of endometriosis: evaluation of pregnancy success with respect to the extent of disease as categorized using contemporary classification system.  Fertil Steril . 1981;  35 131-137
  • 45 Olive D L, Martin D C. Treatment of endometriosis-associated infertility with CO2 laser laparoscopy: the use of one- and two-parameter exponential models.  Fertil Steril . 1987;  48 18-23
  • 46 Nezhat C, Crowgey R, Nezhat F. Videolaseroscopy for the treatment of endometriosis associated with infertility.  Fertil Steril . 1989;  51 237-240
  • 47 Marcoux S, Maheux R, Bérubé S. Laparoscopic surgery in infertile women with minimal or mild endometriosis. Canadian Collaborative Group on Endometriosis.  N Engl J Med . 1997;  337 217-222
  • 48 Gruppo Italiano per lo Studio dell Endometriosis. Ablation of lesions or no treatment in minimal-mild endometriosis in infertile women: a randomized trial.  Hum Reprod . 1999;  14 1332-1334
  • 49 Olive D L. Endometriosis: does surgery make a difference?.  OBG Manage . 2002;  Jul 56-70
  • 50 Paulson J D, Borremeo R, Speck G. The success of laser laparoscopy in the treatment of endometriosis: a two-step analysis.  JSLS . 2001;  5 21-27
  • 51 Donnez J, Chantraine F, Nisolle M. The efficacy of medical and surgical treatment of endometriosis-associated infertility: arguments in favor of a medico-surgical approach.  Hum Reprod Update . 2002;  8 89-94
  • 52 Farquhar C, Vandekerckhove P, Watson A, Vail A, Wiseman D. Barrier agents for preventing adhesions after surgery for subfertility (Cochrane review). The Cochrane Library, Issue 1. Oxford: Update Software; 2000
  • 53 Surrey M W, Hill D L. Treatment of endometriosis by carbon dioxide laser during gamete intrafallopian transfer.  J Am Coll Surg . 1994;  179 440-442
  • 54 Wood C, Mabler P, Hill D. Diagnosis and surgical management of endometriomas.  Aust NZ J Obstet Gynaecol . 1992;  32 161-163
  • 55 Reich H, McGlynn F. Treatment of ovarian endometriomas using laparoscopic surgical techniques.  J Reprod Med . 1986;  31 577-584
  • 56 Adamson G D, Subak L L, Pasta D J. et al . Comparison of CO2 laser laparoscopy with laparotomy for treatment of endometriomata.  Fertil Steril . 1992;  57 965-973
  • 57 Canis M, Mage G, Wattiez A. et al . Second-look laparoscopy after laparoscopic cystectomy of large ovarian endometriomas.  Fertil Steril . 1992;  58 617-619
  • 58 Sayegh R, Garcia C R. Ovarian function after conservational ovarian surgery: a long-term follow-up study.  Int J Gynaecol Obstet . 1992;  39 303-309
  • 59 Donnez J, Wyns C, Nisolle M. Does ovarian surgery for endometriomas impair the ovarian response to gonadotropin?.  Fertil Steril . 2001;  76 662-665
  • 60 Loh F-H, Tan A T, Kumar J, Ng S-C. Ovarian response after laparoscopic ovarian cystectomy for endometriotic cysts in 132 monitored cycles.  Fertil Steril . 1999;  72 316-321
  • 61 Donnez J, Wyns C, Nisolle M. Does ovarian surgery for endometriomas impair the ovarian response to gonadotropin?.  Fertil Steril . 2001;  76 662-665
  • 62 Hemmings R, Bissonnette F, Bouzayen R. Results of laparoscopic treatments of ovarian endometriomas: laparoscopic ovarian fenestration and coagulation.  Fertil Steril . 1998;  70 527-529
  • 63 Muzii L, Bianchi A, Croce C, Manci N, Panici P B. Laparoscopic excision of ovarian cysts: is the stripping technique a tissue-sparing procedure?.  Fertil Steril . 2002;  77 609-614
  • 64 Jones K D, Sutton C JG. Pregnancy rates following ablative laparoscopic surgery for endometriomas.  Hum Reprod . 2002;  17 782-785
  • 65 Canis M, Pouly J L, Tamburro S. et al . Ovarian response during IVF-embryo transfer cycles after laparoscopic ovarian cystectomy for endometriotic cysts of >3cm in diameter.  Hum Reprod . 2001;  16 2583-2586
  • 66 Spandorfer S D, Rosenwaks Z. Endometriosis. Is IVF the answer for infertility? Stage-related success rates in 1417 consecutive IVF-ET cycles. Available at: http://www.obgyn. net/endo/endo.asp?page=/endo/articles/COGI endo IVF. Accessed July 17, 2002
  • 67 Barnhart K, Dunsmoor-Su R, Coutifaris C. Effect of endometriosis on in vitro fertilization.  Fertil Steril . 2002;  77 1148-1155
  • 68 Azem F, Lessing J B, Geva E. et al . Patients with stages III and IV endometriosis have a poorer outcome of in vitro fertilization-embryo transfer than patients with tubal infertility.  Fertil Steril . 1999;  72 1107-1109
  • 69 Wei C F, Chen S C. Pelvic abscess after ultrasound-guided aspiration of endometriomas: a case report.  Zhonghua Yi Xue Za Zhi (Taipei) . 1998;  61 603-607
  • 70 Watson A, Vandekerckhove P, Lilford R. Liquid and fluid agents for preventing adhesions after surgery for subfertility.  Cochrane Rev 1999;Dec 30.
  • 71 Reich H, McGlynn F, Salvat J. Laparoscopic treatment of cul-de-sac obliteration secondary to retrocervical deep fibrotic endometriosis.  J Reprod Med . 1991;  36 516-522
  • 72 Adamson G D, Hurd S J, Rodriguez B D. Laparoscopy versus laparotomy for treatment of posterior cul-de-sac obliteration. Presented at the American Association of Gynecologic Laparoscopists; September 24-27, 1992; Chicago. Abstract
  • 73 Carter J E. A systematic history for the patient with chronic pelvic pain.  JSLS . 1999;  3 245-252
  • 74 Redwine D B. Treatment of endometriosis-associated pain.  Infertil Reprod Med Clin Am . 1994;  3 697-720
  • 75 Nezhat C, Hood J, Winer W. et al . Videolaseroscopy and laser laparoscopy in gynaecology.  Br J Hosp Med . 1987;  38 219-224
  • 76 Propst A M, Laufer M R. Endometriosis in adolescents.  J Reprod Med . 1999;  44 751-758
  • 77 Sutton C JG, Ewen S P, Whitelaw N, Haines P. Prospective, randomized, double-blind controls: trial of laser laparoscopy in the treatment of pelvic pain associated with minimal, mild and moderate endometriosis.  Fertil Steril . 1994;  62 696-700
  • 78 Jones K D, Haines P, Sutton C JG. Long-term follow-up of a controlled trial of laser laparoscopy for pelvic pain.  JSLS . 2002;  5 111-115
  • 79 Candiani G B, Fedele L, Vercellini P, Bianchi S, Di Nola G. Repetitive conservative surgery for recurrence of endometriosis.  Obstet Gynecol . 1991;  77 421-424
  • 80 Schweppe K-W. Preferred treatment for rectovaginal endometriosis: surgery versus medical therapy. Available at: http://www.obgyn.net/endo/endo.asp?page=/endo/articles/COGI rectovaginal. Accessed July 17, 2002
  • 81 Redwine D B, Wright J T. Laparoscopic treatment of complete obliteration of the cul-de-sac associated with endometriosis: long-term follow-up of en bloc resection.  Fertil Steril . 2001;  76 358-365
  • 82 Steege J F. Clinical utility of pelvic pain mapping.  J Am Assoc Gynecol Laparosc . 2001;  8 263-266
  • 83 Fayez J A, Vogel M F. Comparison of different treatment methods of endometriosis by laparoscopy.  Obstet Gynecol . 1991;  78 660-665
  • 84 Kojima E, Morita M, Otaka K, Yano Y. Nd:YAG laser laparoscopy for ovarian endometriomas.  J Reprod Med . 1990;  35 592-596
  • 85 Beretta P, Franchi M, Ghezzi F. et al . Randomized clinical trial of two laparoscopic treatments of endometriomas: cystectomy versus drainage and coagulation.  Fertil Steril . 1998;  70 1176-1180
  • 86 Saleh A, Tulandi T. Reoperation after laparoscopic treatment of ovarian endometriomas by excision and by fenestration.  Fertil Steril . 1999;  72 322-324
  • 87 Meyer W R, Grainger D A, DeCherney A H, Lachs M S, Diamond M P. Ovarian surgery on the rabbit. Effect of cortex closure on adhesion formation and ovarian function.  J Reprod Med . 1991;  36 639-643
  • 88 Redwine D B. Ovarian endometriosis: a marker for more extensive pelvic and intestinal disease.  Fertil Steril . 1999;  72 310-315
  • 89 Olive D L, Schwartz L B. Endometriosis.  N Engl J Med . 1993;  328 1759-1769
  • 90 Walters M D. Definitive surgery. In: Schenken RS, ed. Endometriosis: Contemporary Concepts in Clinical Management Philadelphia: JB Lippincott 1989: 267-278
  • 91 Kresch A J, Seifer D B, Sachs L B, Barrese I. Laparoscopy in 100 women with chronic pelvic pain.  Obstet Gynecol . 1984;  64 672-674
  • 92 Rapkin A J. Adhesions and pelvic pain: a retrospective study.  Obstet Gynecol . 1986;  68 13-15
  • 93 Stout A L, Steege J F, Dodson W C, Hughes C L. Relationship of laparoscopic findings to self-report of pelvic pain.  Am J Obstet Gynecol . 1991;  164 73-79
  • 94 Goldstein D P, DeChoinoky C, Emans S J, Leventhal J M. Laparoscopy in the diagnosis and management of pelvic pain in adolescents.  J Reprod Med . 1980;  24 251-256
  • 95 Sutton C, MacDonald R. Laser laparoscopic adhesiolysis.  J Gynecol Surg . 1990;  6 155-159
  • 96 Steege J F, Stout A L. Resolution of chronic pelvic pain after laparoscopic lysis of adhesions.  Am J Obstet Gynecol . 1991;  165 278-283
  • 97 Peters A A, Trimbos-Kemper G C, Admiraal C, Trimbos J B, Hermans J. A randomized clinical trial on the benefit of adhesiolysis in patients with intraperitoneal adhesions and chronic pelvic pain.  Br J Obstet Gynaecol . 1992;  99 59-62
  • 98 Operative Laparoscopy Study Group. Postoperative adhesion development after operative laparoscopy: evaluation at early second-look procedures.  Fertil Steril . 1991;  55 700-704
  • 99 Tjaden B, Schlaff W D, Kimball A, Rock JA.. The efficacy of presacral neurectomy for the relief of midline dysmenorrhea.  Obstet Gynecol . 1990;  76 89-91
  • 100 Candiani G B, Fedele L, Vercellini P, Bianchi S, Di Nola G. Presacral neurectomy for the treatment of pelvic pain associated with endometriosis: a controlled study.  Am J Obstet Gynecol . 1992;  167 100-103
  • 101 Proctor M L, Farquhar C M, Sinclair O J, Johnson N P. Surgical interruption of pelvic nerve pathways for primary and secondary dysmenorrhoea.  Cochrane Rev 1999;Aug 11.
  • 102 Lichten E M, Bombard J. Surgical treatment of primary dysmenorrhea with laparoscopic uterine nerve ablation.  J Reprod Med . 1987;  32 37-41
  • 103 Franklin R R, Grunert G M. Extragenital endometriosis. In: Oliker AJ, Harris AE, eds. Endometriosis: Advanced Management and Surgical Techniques New York: Springer-Verlag 1995: 128
  • 104 Stones R W, Mountfield J. Interventions for treating chronic pelvic pain in women.  Cochrane Database Syst Rev . 2000;  4 CD000387