Planta Med 2003; 69(7): 623-627
DOI: 10.1055/s-2003-41115
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Antimicrobial Constituents from Goldenseal (the Rhizomes of Hydrastis canadensis) against Selected Oral Pathogens

Bang Yeon Hwang1 , Sara K. Roberts2 , Lucas R. Chadwick1 , Christine D. Wu2 , A. Douglas Kinghorn1
  • 1Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA
  • 2Department of Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
Further Information

Publication History

Received: November 12, 2002

Accepted: March 22, 2003

Publication Date:
04 August 2003 (online)

Abstract

Two new C-methyl flavonoids, 6,8-di-C-methylluteolin 7-methyl ether (1) and 6-C-methylluteolin 7-methyl ether (2), were isolated from a commercially available sample of the roots of Hydrastis canadensis, along with seven known compounds, berberine (3), β-hydrastine (4), canadine (5), canadaline (6), isocorypalmine (7), canadinic acid (8), and β-sitosterol 3-O-β-D-glucoside (9). The structures of the new compounds 1 and 2 were elucidated on the basis of their spectral data including 1D and 2D NMR techniques. Of these isolates, berberine (3) and, to a lesser extent, 1 and 2, showed antimicrobial activity when evaluated against the oral pathogens Streptococcus mutans and Fusobacterium nucleatum. Berberine (3) exhibited an additive antimicrobial effect when tested against S. mutans in combination with 1.

References

Prof. A. Douglas Kinghorn

Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy

College of Pharmacy

University of Illinois at Chicago

Chicago

IL 60612

USA

Phone: +1-312-996-0914

Fax: +1-312-996-7107

Email: kinghorn@uic.edu

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