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Synthesis 2003(10): 1626-1638
DOI: 10.1055/s-2003-40508
FEATUREARTICLE
© Georg Thieme Verlag Stuttgart ˙ New York

Dutch Resolution: Separation of Enantiomers with Families of Resolving Agents. A Status Report

Richard M. Kellogg*a, José W. Nieuwenhuijzena, K. Pouwera, Ton R. Vriesa, Quirinus B. Broxtermanb, Reinier F.P. Grimbergen, Bernard Kapteinb, René M. La Croisa, Ellen de Wevera, Karen Zwaagstraa, Alexander C. van der Laana
a Syncom B.V., Kadijk 3, 9747 AT Groningen, The Netherlands
Fax: +31(50)5757399; e-Mail: r.m.kellogg@syncom.nl;
b DSM Research, Advanced Synthesis and Catalysis, PO Box 18, 6160 MD Geleen, The Netherlands
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Publikationsverlauf

Received 25 February 2003
Publikationsdatum:
08. Juli 2003 (online)

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Abstract

Dutch Resolution is the term given to the use of mixtures (families) of resolving agents in classical resolutions. In this status report an overview is given of the latest results and new (possible) families of resolving agents are introduced. The concept of families is discussed as well as the factors that come into play on use of families. Practical aspects of Dutch Resolution in particular and resolutions in general are discussed.

Key words

amino alcohols - asymmetric synthesis - chiral auxil­iaries - chiral resolution - chirality - camphor - chalcones - sulfonic acids

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Kaptein, B. et al. manuscript in preparation.

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Available from Syncom.