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Exp Clin Endocrinol Diabetes 2003; 111(2): 55-59
DOI: 10.1055/s-2003-39229
Review

J. A. Barth Verlag in Georg Thieme Verlag Stuttgart · New York

Androgen-Induced Vasorelaxation: A Potential Vascular Protective Effect

M. Perusquía 1
  • 1Department of Cell Biology and Physiology, Biomedical Research Institute, National Autonomous University of Mexico, Mexico City, Mexico
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Publikationsverlauf

Received: February 28, 2002 First decision: April 8, 2002

Accepted: August 14, 2002

Publikationsdatum:
14. Mai 2003 (online)

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Abstract

The incidence of morbidity and mortality due to cardiovascular disease is well known to be higher in men than in women. For many years, experimental and clinical studies have focused on the role of androgens in cardiovascular pathology. The clinical implications of androgen deficiency as well as the molecular mechanism of their action have not been well established yet. However, an increasing amount of evidence suggests that androgens may have beneficial effects on the cardiovascular system. The purpose of this article is to review the evidence regarding the vasodilating effect induced by androgens, the mechanism of their action as well as their structure-function relationship.

Key words

Androgens - Vasorelaxation - Nongenomic effects - 5-Reduced steroids - 5β-Dihydrotestosterone

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Ph. D. Mercedes Perusquía

Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, Apdo

Postal 70 - 492, CP 04511

México D.F.

México

Telefon: + 52556223829

Fax: + 52 5 55 50 00 48

eMail: perusqui@servidor.unam.mx

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